Genetic aspects of microangiopathy-related cerebral damage

  • Helena Schmidt
  • F. Fazekas
  • G. M. Kostner
  • R. Schmidt
Conference paper


Microangiopathy related cerebral damage (MARCD) includes early confluent and confluent white matter hyperintensities (WMH) and lacunar lesions. It is expected to be the result of interactions between multiple genetic and environmental factors. The estimated proportion of genetic factors contributing to the interindividual variation seen in WMH volume is 73%. This estimate points to a significant genetic component in WMH development. In the setting of the Austrian Stroke Prevention Study we search for genes being associated with the presence, severity and progression of MARCD using the candidate gene approach. Defining susceptibility genes may allow to better identify individuals at high risk for MARCD and to target preventive measures.


Cerebral Amyloid Angiopathy White Matter Hyperintensities Candidate Gene Approach Cerebral Damage White Matter Hyperintensities Volume 
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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Helena Schmidt
    • 1
  • F. Fazekas
    • 2
  • G. M. Kostner
    • 1
  • R. Schmidt
    • 2
  1. 1.Institute of Medical BiochemistryKarl-Franzens UniversityGrazAustria
  2. 2.Department of NeurologyKarl-Franzens UniversityGrazAustria

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