Epidemiologic clues to the causes and routes to prevention of Alzheimer disease

  • Johns C. S. Breitner
Conference paper


Identification of epidemiologic risk factors serves many purposes. These include 1) identification of high risk groups as potential targets for interventions; 2) identification of the candidate interventions (when the risk factor is susceptible to modification); and 3) suggestion of previously unsuspected causal mechanisms (when the risk relationship is unexpected and not readily explained by current causal theories). Two possible risk relationships will be discussed — one now well-known and the other novel — that may provide a means of reducing the risk of Alzheimer’s disease (AD). I will also suggest a causal theory that encompasses these epidemiologic observations and other recent data.


Alzheimer Disease Prevalence Odds Ratio Epidemiologic Risk Factor Risk Relationship Cache County 
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  1. Selbach O, Brown RE, Haas HL (1997) Long-term increase of hippocampal excitability by histamine and cyclic AMP. Neuropharmacology 36: 1539 – 1548PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2000

Authors and Affiliations

  • Johns C. S. Breitner
    • 1
  1. 1.Department of Mental HygieneJohns Hopkins University School of Public HealthBaltimoreUSA

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