Longitudinal change of white matter abnormalities
A three year follow-up of 273 participants (mean age 60+/—6.1 years) of the Austrian Stroke Prevention Study provides first information on the rate, clinical predictors, and cognitive consequences of MRI white matter hyperintensity in elderly individuals without neuropsychiatric disease. Lesion progression was found in a total of 49 (17.9%) individuals. It was minor in 27 (9.9%) and marked in 22 (8.1%) participants. Diastolic blood pressure (odds ratio 1.07/mmHg) and early confluent or confluent white matter hyperintensities at baseline (odds ratio 2.62) were the only significant predictors of white matter hyperintensity progression. Lesion progression had no influence on the course of neuropsychologic test performance over the observational period.
KeywordsWhite Matter White Matter Hyperintensities White Matter Abnormality Cognitive Vascular Impairment Lesion Progression
Unable to display preview. Download preview PDF.
- Martin CGM, van Swieten JC, Sever AR, Scheltens P, Pieterman H, Breteler MMB (1997) Change in white matter lesions in 60 healthy elderly over a 5-years period, [abstract] J Neurol 244 [Suppl 3]: S23Google Scholar
- Schmidt R, Lechner H, Fazekas F, Niederkorn K, Reinhart B, Grieshofer P, Horner S, Offenbacher H, Koch M, Eber B, Schumacher M, Kapeller P, Freidl W, Dusek T (1994) Assessment of cerebrovascular risk profiles in healthy persons: Definition of research goals and the Austrian Stroke Prevention Study. Neuroepidemiology 13: 308 – 313PubMedCrossRefGoogle Scholar
- Schmidt R, Fazekas F, Kapeller P, Schmidt H, Lechner A (1998) White matter changes and cognitive decline in non-demented subjects. In: Leys D, Pasquier F, Scheltens P et al, Stroke and Alzheimer’s diseases. Current issues in neurodegenerative diseases, vol 9. Holland Academic Graphics, Den Haag, pp 174 – 182Google Scholar