Abstract
We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Arenas E, Persson H (1994) Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Nature 367 (6461): 368 – 371
Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Ann Rev Neurosci 8: 223 – 253
Croll SD, Wiegand SJ, Anderson KD, Lindsay RM, Nawa H (1994) Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NGF. Eur J Neurosci 6 (8): 1343 – 1353
Hock C, Heese K, Hulette C, Rosenberg C, Müller-Spahn F, Otten U (1998) Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer’s disease. Neurosci Lett 241: 1 – 4
Hock C, Heese K, Hulette C, Rosenberg C, Müller-Spahn F, Otten U (1998) Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer’s disease. Neurosci Lett 241: 1 – 4
Hock C, Heese K, Hulette C, Rosenberg C, Müller-Spahn F, Otten U (1998) Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer’s disease. Neurosci Lett 241: 1 – 4
Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230 – 232
Kniisel B, Winslow JW, Rosenthal A, Burton LE, Seid DP, Nicolics K, Hefti F (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain- derived neurotrophic factor but not neurotrophin 3. Proc Natl Acad Sci USA 88: 961 – 965
Mamounas LA, Blue ME, Siuciak JA, Altar CA (1995) Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 15: 7929 – 7939
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939 – 944
Mufson EJ, Conner JM, Kordower JH (1995) Nerve growth factor in Alzheimer’s disease: defective retrograde transport to nucleus basalis. NeuroReport 6: 1063-1066 Palmer AM (1996) Neurochemical studies of Alzheimer’s disease. Neurodegeneration 5 (4): 381 – 391
Selkoe DJ (1994) Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer’s disease. Annu Rev Cell Biol 10: 373 – 403
Weskamp G, Otten U (1987) An enzyme-linked immunoassay for nerve growth factor: a tool for studying regulatory mechanisms involved in NGF production in brain and peripheral tissues. J Neurochem 48: 1779 – 1786
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag
About this paper
Cite this paper
Hock, C. et al. (2000). Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease. In: Jellinger, K., Schmidt, R., Windisch, M. (eds) Advances in Dementia Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6781-6_19
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6781-6_19
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83512-8
Online ISBN: 978-3-7091-6781-6
eBook Packages: Springer Book Archive