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Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease

  • Christoph Hock
  • K. Heese
  • G. Olivieri
  • Ch. Hulette
  • C. Rosenberg
  • R. M. Nitsch
  • U. Otten
Conference paper

Abstract

We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.

Keywords

Nerve Growth Factor Neurotrophin Receptor Cerebrospinal Fluid Level Basal Forebrain Cholinergic System Nerve Growth Factor High Affinity Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Christoph Hock
    • 6
  • K. Heese
    • 2
  • G. Olivieri
    • 3
  • Ch. Hulette
    • 4
  • C. Rosenberg
    • 4
  • R. M. Nitsch
    • 1
  • U. Otten
    • 5
  1. 1.Department of Psychiatry ResearchUniversity of ZürichSwitzerland
  2. 2.BF Research InstituteNational Cardiovascular CenterOsakaJapan
  3. 3.Department of PsychiatryUniversity of BaselSwitzerland
  4. 4.Kathleen Price Bryan Brain BankDuke University Medical CenterDurhamUSA
  5. 5.Department of PhysiologyUniversity of BaselSwitzerland
  6. 6.Department of Psychiatry ResearchUniversity of ZürichZürichSwitzerland

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