Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease
We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.
KeywordsNerve Growth Factor Neurotrophin Receptor Cerebrospinal Fluid Level Basal Forebrain Cholinergic System Nerve Growth Factor High Affinity Receptor
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