Zusammenfassung
Immunsuppressiva sind dadurch charakte- risiert, daß sie eine Abschwachung und eine Unterdruckung der Reaktionsfähigkeit des Immunsystems bewirken, um so uner-wünschte Immunreaktionen zu verhindern. Eine Reihe von therapeutischen Regimen - die meisten sind aus der Onkologie bzw. Rheumatologie bekannt— wurde hinsicht- lich ihrer immunsuppressiven Wirkung bei verschiedenen Lungenerkrankungen unter- sucht. In erster Linie ging es dabei darum, eine mögliche Alternative zu der gängigen Glucocorticoidtherapie zu finden.
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Literatur
. Alexander AG, Barnes NC, Kay AB (1992) Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. Lancet 339: 324 – 328
. Coeffy MJ, Sanders G, Eschenbacher WL, Tsien A, Ramesh S, Weber RW, Toews GB, McCune WJ (1994) The role of methotrexate in the management of steroid-dependent asthma. Chest 105: 117 – 121
. Cott GR, Cherniak RM (1988) Steroids and „steroid-sparing“ agents in asthma. N Engl J Med 318: 634 – 636
. Dayton CS, Schwartz DA, Helmers RA, Pueringer JP, Gilbert SR, Merchant RK, Hunninghake GW (1993) Outcome of subjects with idiopathic pulmonary fibrosis who fail cortocosteroid therapy. Implications for further studies. Chest 103: 69 – 73
. Fauci AS, Haynes BF, Katz P, Wolff SM (1983) Wegener’s granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 98: 76 – 85
. Geddes DM (1991) Methotrexate in asthma. Clin Exp Allergy 21: 541 – 543
. Hill MJ, Tattersfield AE (1995) Corticosteroid sparing agents in asthma. Thorax 50: 577 – 582
. James DG (1992) Treatment of sarcoidosis. Prescribers J 32: 9 – 14
. Johnson MA, Kwan S, Snell NJC, Nunn AJ, Darbyshire JH, Turner-Warwick M (1989) Randomized controlled trial comparing prednisolone alone with cyclophosphamide and low-dose prednisolone in combination in cryptogenic fibrosing alveolitis. Thorax 44: 280 – 288
. Kahan BD (1988) Cyclosporine. Applications in autoimmune diseases. Grunde & Stratton, London
. Leavitt RY, Fauci AS (1986) Pulmonary vasculitis. Am Rev Respir Dis 134: 149 – 166
. Liu JK (1993) FK506 and cyclosporin, molecular probes for studying intracellular signal tranduction. Immunol Today 14: 290 – 295
Lower EE, Baughman RP (1990) the use of low-dose methotrexate in refractory sarcoidosis. Am J Med Sci 229: 153–157
. Mortensen RL, King TE Jr. (1992) Idiopathic pulmonary fibrosis. In: Lichtenstein LM, Fauci AC (eds) Current therapy in allergy, immunology and rheumatology. BC Decker, pp 233 – 241
. Moss RB, MD (1995) Alternative Pharmacotherapies for steroid-dependent asthma. Chest 107: 817 – 825
. Raghu G, DePaso WJ, Cain K, Hammar SP, Wetzel CE, Dreis DF, Hutchinson J, Pardee NE, Winterbauer RH (1991) Azathioprine combined with prednisone in the treatment of idiopathic pulmonary fibrosis: a prospective double-blind, randomized, placebo- controlled clinical trial. Am Rev Respir Med 144: 291 – 296
. Steinberg AD (1973) An approach to the use of immunosuppressive drugs in nonmali- gnant disease. J Allergy Clin Immunol 52: 242 – 250
. Weese WC, Levine BW, Kazemi H (1975) Interstitial lung disease resistant to corticosteroid therapy. Report of three cases treated with azathioprine or cyclophosphamide. Chest 67: 57 – 60
. Winterbauer RH (1991) The treatment of idiopathic pulmonary fibrosis. Chest 100: 233 – 235
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Pohl, R.W., Klech, H. (2000). Immunsuppressiva und Zytostatika: Immunsuppressiva bei bronchopulmonalen Erkrankungen. In: Kummer, F., Konietzko, N., Medici, T.C. (eds) Pharmakotherapie bronchopulmonaler Erkrankungen. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6761-8_26
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DOI: https://doi.org/10.1007/978-3-7091-6761-8_26
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