Polysomnography in transgenic hSOD1 mice as Down syndrome model

  • D. Colas
  • J. London
  • R. Cespuglio
  • N. Sarda
Part of the Journal of Neural Transmission Supplement 67 book series (NEURAL SUPPL, volume 67)


Sleep-wake homeostasis is crucial for behavioral performances and memory in the general population and in learning disability populations among them Down syndrome patients. We investigated, in a mouse model of Down syndrome, cortical EEG and sleep-wake architecture under baseline conditions and after a 4hr sleep deprivation (SD). Young heterozygous transgenic mice (S/+) for the human Cu/Zn superoxide dismutase (hSOD-1) were obtained on FVB/N background. Baseline records for slow wave sleep (SWS) and wake (W) parameters were the same in S/+ and control mice whereas paradoxical sleep (PS) episode number decreased and PS latency increased after light off in S/+ mice. These data correlate well the polysomnographic phenotype of young DS patients.


Down Syndrome Sleep Deprivation Slow Wave Sleep Paradoxical Sleep Down Syndrome Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Down’s syndrome


human CuZn superoxide dismutase 1


paradoxical sleep


slow wave sleep




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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • D. Colas
    • 1
  • J. London
    • 2
  • R. Cespuglio
    • 1
  • N. Sarda
    • 1
    • 3
  1. 1.INSERM Unit 480Claude Bernard UniversityLyonFrance
  2. 2.EA 3508Paris 7 Denis-Diderot UniversityParisFrance
  3. 3.INSERM Unit 480Claude Bernard UniversityLyonFrance

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