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The MNB/DYRK1A protein kinase: Genetic and biochemical properties

  • J. Galceran
  • K. de Graaf
  • F. J. Tejedor
  • W. Becker
Part of the Journal of Neural Transmission Supplement 67 book series (NEURAL SUPPL, volume 67)

Summary

The “Down syndrome critical region” of human chromosome 21 has been defined based on the analysis of rare cases of partial trisomy 21. Evidence is accumulating that DYRK1A, one of the 20 genes located in this region, is an important candidate gene involved in the neurobiological alterations of Down syndrome. Both the structure of the DYRK1A gene and the sequence of the encoded protein kinase are highly conserved in evolution. The protein contains a unique assembly of structural motifs outside the catalytic domain, including a nuclear localization signal, a PEST region, and a repeat of 13 consecutive histidines. MNB/DYRK1A* and related kinases are unique among serine/threonine-specific protein kinases in that their activity depends on tyrosine autophosphorylation in the catalytic domain. Also, evidence is accumulating that mRNA levels of MNB/DYRK1A are subject to tight regulation. A number of putative substrates of MNB/DYRK1A have emerged in the recent years, the majority of them being transcription factors. Although the function of MNB/DYRK1A in intracellular signalling and regulation of cell function is still poorly defined, current evidence suggests that the kinase may play a role in the regulation of gene expression.

Keywords

Down Syndrome Catalytic Domain Partial Trisomy Putative Substrate Pest Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • J. Galceran
    • 1
  • K. de Graaf
    • 2
  • F. J. Tejedor
    • 1
  • W. Becker
    • 2
    • 3
  1. 1.Instituto de Neurociencias, Unidad de Neurobiologia del Desarrollo, CSIC yUniversidad Miguel Hernandez Campus de San JuanSan Juan AlicanteSpain
  2. 2.Institut für Pharmakologie und Toxikologie, Medizinische FakultätRWTH AachenAachenGermany
  3. 3.Institut für Pharmakologie und ToxikologieMedizinische Fakultät der RWTH AachenAachenGermany

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