Surgery in the dorsal root entry-zone: microsurgical DREZ-tomy (MDT) for the treatment of spasticity

  • M. Sindou
  • D. Jeanmonod
  • P. Mertens


Microsurgical-DREZ-tomy (MDT) was first introduced for the treatment of pain. In the 1960s’ a large amount of anatomical and physiological work drew clinicians’ attention to the dorsal horn (Melzach and Wall 1965) as the first level of modulation for pain sensation. This research convinced the senior author to consider the dorsal root entry zone (DREZ) as a possible target for pain surgery. Therefore in 1972 anatomical studies and preliminary surgical trials were undertaken in man, in order to determine whether a destructive procedure at this level was feasible (Sindou 1972, Sindou et al. 1974c).


Spinal Cord Dorsal Root Dorsal Horn Voluntary Movement Dorsal Column 
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Copyright information

© Springer-Verlag Wien 1991

Authors and Affiliations

  • M. Sindou
    • 1
  • D. Jeanmonod
    • 1
  • P. Mertens
    • 1
  1. 1.Department of NeurosurgeryHopital Neurologique Pierre WertheimerLyonFrance

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