Intrathecal infusion of baclofen for spasticity: the RUSH and the US multicenter studies

Abstract

The ideal treatment for spasticity should have the following characteristics. First, it should not damage any part of the nervous system which is functioning normally or has the potential for recovery. Thus, motor and sensory pathways would remain intact so that no further neurological loss would be inflicted by the treatment. Second, it should be reversible, so that as the degree of spasticity changes, the treatment could be adjusted appropriately. A corollary is that it should be effective with mild spasticity as well as the most severe. Third, it should involve as little surgical intervention as possible because of the already compromised medical status of the patient. Finally, there should be a way to test if it will work before employing the technique.