Pharmacological bases of intrathecal Baclofen administration
In 1912, Babinski wrote “I had often wondered, when faced with patients stricken by paraplegia with severe spasms, who seemed to have kept their full muscular strength, if it would not be feasible to try to eliminate the spasms by means of a surgical procedure directed at the posterior root; yet the fear of complications had always prevented me from carrying out this theory. Two years later, in 1908, Foerster was credited with the realization and implementation of the technique of the operation that now carries his name. This operation has been used mostly for the treatment of Little’s disease and has quite often been successful. But this operation includes risks; it would be abandoned without hesitation if some day a new substance were found capable of abolishing or diminishing the tendinous reflexia without side effects” (Babinski 1912).
KeywordsDorsal Horn Ventral Horn Posterior Root Capsaicin Treatment Severe Spasm
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