Pulmonary Hemodynamics in Sleep Apnea
When you consider pulmonary hemodynamics in obstructive sleep apnea, obviously the question is: what is the link between the occurrence of apneas during sleep and the development of what was called the “Pickwickian syndrome”? - that is, a picture of a fat, sleepy patient who has cardiorespiratory failure. This was the question behind the first studies. The early studies which have been performed in this field were reported in a very early paper published in the 1972 report of the Rimini Meeting; Coccagna and coworkers showed that the pulmonary arterial pressure increased during sleep as compared to baseline pulmonary arterial pressure during the awake state. This increase appeared during the obstructive apnea episodes, with a further increase on breathing resumption. They also stressed the very marked oscillations during the obstructive episodes related to the ineffective respiratory episodes.
KeywordsObstructive Sleep Apnea Pulmonary Hypertension Sleep Apnea Obstructive Sleep Apnea Syndrome Atrial Natriuretic Peptide
Unable to display preview. Download preview PDF.
- 2.Coccagna G., Mantovani M., Brignani F., Parchi C., Lugaresi E.: Continuous recording of the pulmonary and systemic arterial pressure during sleep in syndromes of hypersomnia with periodic breathing. Bull Physiopathol Respir (1972) 8: 1159–1172.Google Scholar
- 5.Krieger J., Laks L., Wilcox I., Grunstein R.R., Costas L.J.V., McDougall J.G., Sullivan C.E.: Atrial natriuretic peptide release during sleep in patients with obstructive sleep apnoea before and during treatment with nasal continuous positive airway pressure. Clin Sci (1989) 77: 407–411.PubMedGoogle Scholar
- 6.Krieger J., Sforza E., Apprill M., Lampert E., Weitzenblum E., Ratomaharo J.: Pulmonary hypertension, hypoxemia, and hypercapnia in obstructive sleep apnea patients Chest (1989) 96: 729–737.Google Scholar
- 8.Krieger J.: Mechanisms of daytime pulmonary hypertension and altered renal function in obstructive sleep apnea. In: Obstructive sleep apnea syndrome. Clinical Research and Treatment. Eds, Guilleminault C., Partinen M. Raven Press, New York, 1990, pp 71–80.Google Scholar
- 9.Londsdorfer J., Meunier-Carus J., Lampert-Benignus E., et al: Aspects hemodynamiques et respiratoires du syndrome pickwickien. Bull Physiopath Resp (1972) 8: 1181–1192.Google Scholar
- 11.Marrone O, Ferrara G., Macaluso C., Milone F., Cibella F., Bellia V., Bonsignore G.: Hemodynamics in obstructive sleep apnea syndrome patients treated by continuous positive airway pressure. In: Sleep related disorders and internal diseases. Eds, Peter J.H., Podszus T., Wichert P. von. Springer, Berlin Heidelberg New York, 1987, pp 375–379.CrossRefGoogle Scholar
- 12.Schroeder J.S., Motta J., Guilleminault C.: Hemodynamic studies in sleep apnea. In: Sleep apnea syndromes. Eds, Guilleminault C, Dement W.C., Alan R. Liss, New York, 1978, pp 177–196.Google Scholar