Zusammenfassung
Dieses Kapitel über Pharmakokinetik sollte nur als Einführung in ein Gebiet angesehen werden, das in anderen, sich ausschliesslich mit diesem Bereich beschäftigenden Werken umfassender beschrieben wurde (Tozer 1981, Rowland und Tozer 1989, Gilman et al. 1990, Klotz 1983). Es behandelt die quantitativen Beziehungen, die zwischen der Verabreichung eines Medikamentes und seiner klinischen Wirkung bestehen. Die hier dargestellten Beispiele dienen nur zur Illustration, da die Kinetik und Dynamik einzelner Pharmakagruppen in den jeweiligen Kapiteln eingehend beschrieben werden. Die zwei folgenden Begriffe verlangen eine genaue Definition: Die Pharmakokinetik befaßt sich mit den Zusammenhängen zwischen der Medikamentendosis, seiner Verabreichungsart und den Konzentrationen der aktiven Komponente am Wirkungsort oder Rezeptor. Da diese in den meisten Fällen nicht meßbar sind, werden sie vereinfachend den Konzentrationen des freien, nicht an Eiweiße gebundenen Wirkstoffes im Plasma gleichgesetzt.
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Buclin, T., Baumann, P. (1992). Allgemeine Grundlagen der Pharmakokinetik und Pharmakodynamik. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6674-1_11
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