Functional Imaging of Blood Brain Barrier Permeability by Single Photon Emission Computerised Tomography and Positron Emission Tomography

  • F. Iannotti
Part of the Advances and Technical Standards in Neurosurgery book series (NEUROSURGERY, volume 19)


A variety of insults, affecting the Central Nervous System (CNS) can alter the structure and function of brain endothelial cells, resulting in a disturbance of Blood-Brain Barrier (BBB) permeability. Alteration of permeability promotes the accumulation of osmotically active substances in the brain and development of an “open barrier” oedema1. This event may be the single most important factor in the outcome of patients with a variety of clinical disorders. On the other hand the entry into the brain ECS of substances which are normally excluded may directly affect, independently from the presence of oedema, the function and perhaps the structure of nervous cells2. Therefore, while the alteration of BBB permeability may be the consequence of a particular disease, it is also the cause of additional damage to the CNS.


Positron Emission Tomography Positron Emission Tomography Study Cereb Blood Flow Single Photon Emission Computerise Tomography Positron Emission Tomography Evaluation 
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Copyright information

© Springer-Verlag/Wien 1992

Authors and Affiliations

  • F. Iannotti
    • 1
  1. 1.Istituto di Neurochirurgia, I Facoltà MedicaUniversità degli Studi di NapoliNapoliItaly

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