Spatiotemporal Modeling on ECoG, Scalp-EEG and MEG
One of the major problems in clinical neurophysiology has been the investigation of physiological as well as pathological processes involving multiple simultaneously active brain regions using electrical and magnetic measurements [21, 29, 32, 34, 40, 41, 42, 138, 259, 319, 320, 321, 322, 323, 324, 325, 326, 379]. In this context, it is important to recognize that electric potentials or magnetic fields measured at the scalp do not merely reflect activity of neuronal populations immediately underlying the measurement site. Actually, many different and even remote neuronal populations, which are active simultaneously, contribute to scalp electric and magnetic recordings [258, 259]. Thus, the application of methods which allow modeling of multiple simultaneously active brain regions is warranted. We used spatiotemporal modeling to deal with this problem and applied a combined approach of principal component analysis (PCA) and multiple dipole modeling which will be outlined in the following.
KeywordsSpatiotemporal Pattern Spatiotemporal Modeling Single Dipole Significant Principal Component Successive Time Point
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