Differential diagnosis of PSP

  • R. C. Duvoisin
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 42)


The clinical diagnosis of PSP depends primarily on the history and the physical findings. Clinicans should be alerted to the possibility of this condition in assessing patients presenting with atypical parkinsonism and other complex extrapyramidal syndromes in late middle age or later. The differential diagnosis includes MSA (both OPCA and SND), PD, CBD and cerebrovascular disease. PD is probably the most common erroneous diagnosis. Unfortunately, pathognomonic signs do not usually appear until several years after symptom onset. No specific laboratory test is yet available. Neuroimaging studies show characteristic anatomic alterations only late in the course of the illness and must be correlated with the clinical findings.


Single Photon Emission Compute Tomography Multiple System Atrophy Progressive Supranuclear Palsy Progressive Supranuclear Palsy Progressive Supranuclear Palsy Patient 
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Copyright information

© Springer-Verlag Wien 1994

Authors and Affiliations

  • R. C. Duvoisin
    • 1
  1. 1.Department of NeurologyUniversity of Medicine and Dentistry of New JerseyNew BrunswickUSA

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