Summary
The EMG characteristics of the normal auditory startle response in man are compatible with an origin in the pontine reticular formation and with conduction down the spinal cord in a slowly conducting, possibly reticulo-spinal pathway. The startle was reduced or absent in patients with progressive psupranuclear palsy, consistent with loss of neurones in the lower pontine reticular formation. In contrast, the startle was present and of normal form in patients with Parkinson’s disease. However, it was delayed in onset. This result was not influenced by treatment with L-dopa. The late auditory startle in Parkinson’s disease might be related to withdrawal of facilitatory input to brainstem centres from the basal ganglia.
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References
Brown P, Rothwell JC, Thompson PD, Day BL, Marsden CD (1991) New observations on the normal auditory startle reflex in man. Brain 114: 1891–1902.
Colebatch JG, Barrett G, Lees AJ (1990) Exaggerated startle reflexes in an elderly woman. Mov Dis 5: 167–169.
Davis M, Gendelman DS, Tischler MD, Gendelman PM (1982) A primary acoustic startle circuit: lesion and stimulation studies. J Neurosci 2: 791–805.
Grillner S, Lund S (1968) The origin of a descending pathway with monosynaptic action on flexor motoneurones. Acta Physiol Scand 74: 274–284.
Groves PM, Wilson CJ, Boyle RD (1974) Brainstem pathways, cortical modulation, and habituation of the acoustic startle response. Behav Biol 10: 391–418.
Hammond GR (1973) Lesions of the pontine and medullary reticular formation and prestimulus inhibition of the acoustic startle reaction in rats. Physiol Behav 10: 239–243.
Hori A, Yasuhara A, Naito H, Yasuhara M (1986) Blink relfex elicited by auditory stimulation in the rabbit. J Neurol Sci 76: 49–59.
Juncos JL, Hirsch EC, Malessa S, Duyckaerts C, Hersh LB, Agid Y (1991) Mesencephalic cholinergic nuclei in progressive supranuclear palsy. Neurology 41: 25–30.
Lakke JP (1985) Axial apraxia in Parkinson’s disease. J Neurol Sci 69: 37–46.
Lees AJ (1987) The Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). In: Marsden CD, Fahn S (eds) Movement disorders, vol 2. Butterworths, London, pp 272–287.
Malessa S, Hirsch EC, Cervera P, Javoy-Agid F, Duyckaerts C, Hauw JJ, et al (1991) Progressive supranuclear palsy: loss of choline acetyltransferase-like immunoreactive neurones in the pontine reticular formation. Neurology 41: 1593–1597.
Olszewski J, Baxter D (1954) Cytoarchitecture of the human brain stem. Lippincott, Philadelphia.
Steele JC, Richardson JC, Olszewski J (1964) Progressive supranuclear palsy: a hetero-genous degeneration involving the brainstem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch Neurol 10: 333–359.
Taber E (1961) The cytoarchitecture of the brain stem of the cat. I. Brain stem nuclei of cat. J Comp Neurol 116: 27–69.
Tolosa ES, Zeese JA (1979) Brainstem auditory evoked responses in progressive supranuclear palsy. Ann Neurol 6: 369.
Vidialhet M, Rothwell JC, Thompson PD, Lees AJ, Marsden CD (1992) The auditory startle response in Steele-Richardson-Olszewski syndrome and Parkinson’s disease. Brain 115: 1181–1192.
Wiener WJ, Lang AE (1989) Parkinson’s disease. In: Movement disorders: a comprehensive survey. Futura, New York, pp 23–115.
Wu MF, Suzuki SS, Siegel JM (1988) Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle. Brain Res 457: 399–406.
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© 1994 Springer-Verlag Wien
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Rothwell, J.C., Vidailhet, M., Thompson, P.D., Lees, A.J., Marsden, C.D. (1994). The auditory startle response in progressive supranuclear palsy. In: Tolosa, E., Duvoisin, R., Cruz-Sánchez, F.F. (eds) Progressive Supranuclear Palsy: Diagnosis, Pathology, and Therapy. Journal of Neural Transmission. Supplementa, vol 42. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6641-3_4
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DOI: https://doi.org/10.1007/978-3-7091-6641-3_4
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