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The auditory startle response in progressive supranuclear palsy

  • J. C. Rothwell
  • M. Vidailhet
  • P. D. Thompson
  • A. J. Lees
  • C. D. Marsden
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 42)

Summary

The EMG characteristics of the normal auditory startle response in man are compatible with an origin in the pontine reticular formation and with conduction down the spinal cord in a slowly conducting, possibly reticulo-spinal pathway. The startle was reduced or absent in patients with progressive psupranuclear palsy, consistent with loss of neurones in the lower pontine reticular formation. In contrast, the startle was present and of normal form in patients with Parkinson’s disease. However, it was delayed in onset. This result was not influenced by treatment with L-dopa. The late auditory startle in Parkinson’s disease might be related to withdrawal of facilitatory input to brainstem centres from the basal ganglia.

Keywords

Startle Response Progressive Supranuclear Palsy Rectus Abdominis Acoustic Startle Abductor Pollicis Brevis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1994

Authors and Affiliations

  • J. C. Rothwell
    • 1
  • M. Vidailhet
    • 1
  • P. D. Thompson
    • 1
  • A. J. Lees
    • 1
  • C. D. Marsden
    • 1
  1. 1.Institute of NeurologyMRC Human Movement and Balance UnitLondonUK

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