Cholinergic approaches to the treatment of progressive supranuclear palsy

  • I. Litvan
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 42)


In spite of the severe loss of cholinergic neurons in the brains of patients with progressive supranuclear palsy (PSP), marginal or null benefits are seen in clinical trials after the administration of physostigmine, a cholinesterase inhibitor, or RS-86, a cholinergic agonist. The possible role of cholinergic therapy in PSP is reevaluated.


Progressive Supranuclear Palsy Pedunculopontine Nucleus Pseudobulbar Palsy Selective Remind Oral Physostigmine 
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Copyright information

© Springer-Verlag Wien 1994

Authors and Affiliations

  • I. Litvan
    • 1
    • 2
  1. 1.Neuroepidemiology BranchNational Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  2. 2.Neuroepidemiology BranchNational Institutes of Neurological Disorders and StrokeBethesdaUSA

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