Cholinergic and peptidergic systems in PSP

  • F. Javoy-Agid
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 42)


PSP is associated with a widespread cholinergic deficit likely corresponding to a loss in cholinergic neurons. The cholinergic damage dramatically affects the basal ganglia and specific cell groups of the mes-encephalon and pons. This provides an anatomically defined basis for motor and supranuclear oculomotor syndromes characteristic of PSP.

Unlike Alzheimer’s disease and Parkinson’s disease with dementia, the disease is not associated with a marked cholinergic deficiency in the cerebral cortex.

Various peptides are present at normal concentrations in extrapyramidal and limbic subcortical areas in brains of patients with PSP. Of particular interest, is somatostatin, the levels of which are subnormal in cerebral cortex of patients with dementia of Alzheimer’ or Parkinson’s disease type.


Substantia Nigra Cholinergic Neuron Progressive Supranuclear Palsy ChAT Activity Cholinergic Innervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1994

Authors and Affiliations

  • F. Javoy-Agid
    • 1
    • 2
  1. 1.INSERM U 289Hôpital de la SalpêtrièreParisFrance
  2. 2.Laboratoire de Medicine ExperimentaleHôpital de la SalpêtrièreParisFrance

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