Brain morphology and prediction of neuroleptic treatment response in schizophrenia
Since the introduction of computed tomography into schizophrenia research, many studies were performed to correlate brain morphology with neuroleptic treatment response. CT measures like the VBR, third ventricular size, cerebral asymmetry and cortical enlargement yielded equivocal results. As temporal and frontal lobe structures are involved in the pathophysiology of schizophrenia, a CT scan study with 143 schizophrenic responders and non-responders after 4 weeks of haloperidol treatment was performed using 12 different measures focussing on frontal and peritemporal cerebrospinal fluid spaces. Beside a significantly enlarged basotemporal, a trendwise enlarged parasagittal cerebrospinal fluid space, and a significantly reduced frontal lobe asymmetry in non-responders, none of the other measures helped to predict short-term neuroleptic response. Methodological problems of this study and future perspectives of brain morphology in treatment prediction research are discussed.
KeywordsSchizophrenic Patient Occipital Lobe Chronic Schizophrenia Brain Morphology Temporal Horn
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