Autosomal recessive sensory neuropathy with selective reduction of small myelinated fibres

  • M. Donaghy
  • P. K. Thomas
Conference paper


Three members of a Kashmiri family were affected by a new variant of hereditary sensory and autonomic neuropathy with autosomal recessive inheritance. Pain and thermal sensations, and sweating were impaired. Motor and sensory functions attributable to large myelinated fibres, and routine nerve conduction studies were normal. Sural nerve biopsy revealed selective reduction of the small myelinated fibre population; large myelinated fibres were normal. All three patients exhibited corneal opacification due to neurotrophic keratitis.


Sensory Neuropathy Corneal Opacification Unmyelinated Axon Sural Nerve Biopsy Myelinated Nerve Fibre 
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Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • M. Donaghy
    • 1
  • P. K. Thomas
    • 2
  1. 1.Department of Clinical NeurologyRadcliffe InfirmaryOxfordUK
  2. 2.Department of Neurological SciencesRoyal Free Hospital School of MedicineLondonUK

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