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Peripheral nerve dysfunction in chronic obstructive pulmonary disease

  • G. Boné
  • G. Ladurner
  • M. Rolke
  • D. Nolte
Conference paper

Summary

48 patients with chronic obstructive pulmonary disease (COPD) have been investigated in regard to clinical and electrophysiological signs of peripheral nerve dysfunction. None of the COPD patients had any obvious cause of peripheral neuropathy. Diagnosis of definite peripheral neuropathy clinical and subclinical — has been done in 27% of the hypoxemic COPD patients vs 9% of the normoxemic COPD patients.

The mean values of the median and peroneal nerve conduction velocities were significantly lower in the hypoxemic COPD group with neuropathy than in those without.

Diagnosis of PN was significantly correlated with PaO2 respectively the degree of hypoxemia in the hypoxemic COPD patients. PaO2 was a significant predictor variable for discrimination between patients with and without peripheral neuropathy.

Keywords

Chronic Obstructive Pulmonary Disease Peripheral Neuropathy Chronic Obstructive Pulmonary Disease Patient Conduction Velocity Chronic Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Adams RD, Victor M (1981) Hypoxic — hypotensive encephalopathy. Hypercapnia and hypoxia in pulmonary disease. In: Adams RD, Victor M (eds) Principles of neurology. McGraw-Hill: New York, pp 729–732Google Scholar
  2. 2.
    Alani SM, Twomey JA, Peake MD (1985) Almitrine and peripheral neuropathy. Lancet 2: 1251PubMedCrossRefGoogle Scholar
  3. 3.
    Appenzeller D, Parks RD, McGee J (1968) Peripheral neuropathy in chronic disease of the respiratory tract. Am J Med 44: 873–880PubMedCrossRefGoogle Scholar
  4. 4.
    Dyck PJ, Thomas PK, Lambert EH (1984) Peripheral neuropathy, vols 1 and 2. Saunders: Philadelphia London TorontoGoogle Scholar
  5. 5.
    Faden A, Mendoza E, Flynn F (1981) Subclinical neuropathy associated with chronic obstructive pulmonary disease. Arch Neurol 38: 639–642PubMedCrossRefGoogle Scholar
  6. 6.
    Louarn F, Gherardi R (1985) Almitrine and peripheral neuropathy. Lancet ii: 1068CrossRefGoogle Scholar
  7. 7.
    Low PA, Nikuda H, Schmelzer JD, Dyck PJ (1985) Endoneurial oxygen tension and radial topography in nerve edema. Brain Res 341: 147–158PubMedCrossRefGoogle Scholar
  8. 8.
    Ludin HP, Tackmann W (1979) Sensible Neurographie. Thieme: StuttgartGoogle Scholar
  9. 9.
    Ludin HP (1981) Praktische Elektromyographie. Enke: StuttgartGoogle Scholar
  10. 10.
    Moore N, Lerebours G, Senant J, Ozenne G, David Ph, Nouvet G (1985) Peripheral neuropathy in chronic obstructive lung disease. Lancet ii: 1311CrossRefGoogle Scholar
  11. 11.
    Narayan M, Ferranti R (1978) Nerve conduction impairment in patients with respiratory insufficiency and severe chronic hypoxemia. Arch Phys Med Rehabil 59: 188–192PubMedGoogle Scholar
  12. 12.
    Pfeiffer G, Kunze K, Bruch M, Kutzner M, Ladurner G, Malin JP, Tackmann W (1990) Polyneuropathy associated with chronic hypoxaemia: prevalence in patients with chronic obstructive pulmonary disease. J Neurol 237 (4): 230–233PubMedCrossRefGoogle Scholar
  13. 13.
    Tuck R, Schmelzer JD, Low PA (1984) Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy. Brain 107: 935–950PubMedCrossRefGoogle Scholar
  14. 14.
    Vazque JO (1979) Neurological manifestations of chronic respiratory diseases. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 38. North Holland: Amsterdam, pp 285–307Google Scholar
  15. 15.
    Vinken PJ, Bruyn GW, Klawans HL (1987) Neuropathies. Handbook of clinical neurology, vol 7 (51). Elsevier: AmsterdamGoogle Scholar

Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • G. Boné
    • 1
  • G. Ladurner
    • 1
  • M. Rolke
    • 2
  • D. Nolte
    • 2
  1. 1.Department of NeurologySalzburgAustria
  2. 2.Department of PulmonologyBad ReichenhallGermany

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