Propylene oxide causes central-peripheral distal axonopathy in rats

  • A. Ohnishi
  • T. Yamamoto
  • Y. Murai
  • Y. Hayashida
  • H. Hori
  • T. Tanaka
Conference paper


In Wistar rats subjected daily to a 6-hour exposure of propylene oxide (PO) at a concentration of 1,500 ppm (5 times a week for 7 weeks), ataxia developed in the hindlegs. Myelinated fibers in the hindleg nerves and in the fasciculus gracilis showed axonal degeneration, sparing the nerve cell body of the first sacral dorsal root ganglion and myelinated fibers of the first sacral dorsal and ventral roots. These pathologic findings are compatible with central-peripheral distal axonopathy. This is apparently the first animal model of PO neuropathy to be verified histologically.


Ethylene Oxide Peroneal Nerve Sural Nerve Propylene Oxide Axonal Degeneration 
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Copyright information

© Springer-Verlag Wien 1995

Authors and Affiliations

  • A. Ohnishi
    • 1
  • T. Yamamoto
    • 1
  • Y. Murai
    • 1
  • Y. Hayashida
    • 2
  • H. Hori
    • 3
  • T. Tanaka
    • 3
  1. 1.Department of Neurology, Institute of Industrial Ecological SciencesUniversity of Occupational and Environmental HealthKitakyushuJapan
  2. 2.Department of Systems Physiology, Institute of Industrial Ecological SciencesUniversity of Occupational and Environmental HealthKitakyushuJapan
  3. 3.Department of Environmental Health Engineering, Institute of Industrial Ecological SciencesUniversity of Occupational and Environmental HealthKitakyushuJapan

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