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Zusammenfassung

Die Behandlung älterer Menschen mit Psychopharmaka ist allgemein mit folgenden Schwierigkeiten konfrontiert.

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Literatur

  • Addonizio G (1987) Neuroleptic malignant syndrome in elderly patients. J Am Ger Soc 35: 1011–1012

    CAS  Google Scholar 

  • Agnolia A et al (1988) Randomized doube-blind study of flunarizin versus placebo in patients with chronic cerebrovascular disorders. Int J Clin Pharmacol Res 3: 189–197

    Google Scholar 

  • Alexopoulos GS (1992) Treatment of depression. In: Salzman C (ed) Clinical geriatric psycho-pharmacology, 2nd edn. Williams & Wilkins, Baltimore, Tokyo, pp 137–174

    Google Scholar 

  • Herrmann WM, Kern U (1987) Nootropica: Wirkungen und Wirksamkeit. Eine Überlegung am Beispiel einer Phase III-Prüfung mit Piracetam. Nervenarzt 58: 358–364

    PubMed  CAS  Google Scholar 

  • Amrein R (1992) Interactions of moclobemide with concomitantly administered medication: evidence form pharmacological and clinical studies. Psychopharmacology 106 [Suppl]: 24–31

    Google Scholar 

  • Angst J, Stabl M (1992) Efficacy of moclobemid in different patient groups: a meta-analysis of studies. Psychopharmacology (Berl) 106 [Suppl]: 109–113

    Google Scholar 

  • Bannister SJ et al (1989) Evaluation of the potential of the interactions of paroxetine with diazepam, Cimetidine, warfarin and digoxin. Acta Psychiatr Scand 80 [Suppl 350]: 102–106

    Google Scholar 

  • Barnes R, Veith R, Okimoto J (1982) Efficacy of antipsychotic medications in behaviorally disturbed dementia patients. Am J Psychiatry 139: 1170–1174

    PubMed  CAS  Google Scholar 

  • Beasley CM et al (1991) Fluoxetine and suicide: a metaanalysis of controlled trials of treatment of depression. Br Med J 303: 685–692

    Google Scholar 

  • Beckmann H (1983) Therapie mit nicht-trizyklischen Antidepressiva. In: Langer G, Heimann H (Hrsg) Psychopharmaka: Grundlagen und Therapie. Springer, Wien New York, S 140–159

    Google Scholar 

  • Benfeld P, Ward A (1986) Fluvoxamine. A review of ist pharmadynamic and pharmakocokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32: 313–334

    Google Scholar 

  • Bergstrom RF, Peyton AL, Lemberger L (1992) Quantification and mechanism of fluoxetine and tricyclic antidepressant interaction. Clin Pharmacol The 51: 239–248

    CAS  Google Scholar 

  • Berntmann L, Siesjö BK (1978) Brain energy metabolism and circulation in hypoxia. Proc Eu-rop Soc Neurochem 1: 253–326

    Google Scholar 

  • Bittles AH (1991) Biological aspects of ageing. In: Jacoby R, Oppenteimer C (eds) Psychiatry in the elderly. Oxford University Press, Oxford New York Tokyo, pp 3–34

    Google Scholar 

  • Blaha L (1978) Behandlungsprobleme in der Gerontopsychiatrie In: Flügel KA (ed) Neurologische und psychiatrische Therapie. Peri-med, Erlangen, S 397–402

    Google Scholar 

  • Blazer HG et al (1983) The risk of anticholinergic toxicity in the elderly: a study prescribing practices in two populations. J Gerontol 38: 31–35

    PubMed  Google Scholar 

  • Boakes AJ, Lauwrence DR, Teoh PC (1973) Interactions between sympathomimetic amines and antidepressant agents in man. Br Med J 1: 311–315

    PubMed  CAS  Google Scholar 

  • Bohm C et al (1990) Buspirone therapy in anxious elderly patients: a controlled clinical trial. J Clin Psychopharmacology 10 [Suppl 31]: 47–51

    Google Scholar 

  • Bouchard RH, Pourcher E, Vincent P (1989) Fluoxetine and extrapyramidal side effects. Am J Psychiatry 146: 352–1353

    Google Scholar 

  • Boyer WF, Feighner JP (1991) Side effects of the selective serotonin re-uptake inhibitors. In: Feighner JP, Boyer WF (eds) Perspectives in psychiatry, vol 1. Selective serotonin reuptake inhibitors. Wiley, Chichester, pp 133–152

    Google Scholar 

  • Boyer WF, Feighner JP (1991) Pharmacokinetics and drug interactions. In: Feighner JP, Boyer WF (eds) Perspectives in psychiatry, vol 1. Selective serotonin re-uptake inhibitors. Wiley, Chichester, pp 81–88

    Google Scholar 

  • Bressler R, Katz MD (1993) Drug therapy for geriatric depression. Drugs Aging 3: 195–219

    PubMed  CAS  Google Scholar 

  • Briantr RH, Reid JL, Dollery CT (1973) Interaction between Clonidine and desipramine in man. Br Med J 1: 522–523

    Google Scholar 

  • Brosen K, Skjelbo E (1991) Fluoxetine and nor-fluoxetine are potent inhibitors of P450IID6, the source of sparteine/debrisoquine oxidation polymorphism. Br J Clin Pharmacol 32: 136–137

    PubMed  CAS  Google Scholar 

  • Brosen K, Gram LF, Kragh-Sorenson P (1991) Extremly slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine and mephenytoin. Ther Drug Monit 13: 177–182

    PubMed  CAS  Google Scholar 

  • Brown CS et al (1990) Possible influence of carba-mazepine on plasma imipramine concentration in children with attention-deficit hyperactivity disorder. J Clin Psychopharmacol 10: 359–362

    PubMed  CAS  Google Scholar 

  • Brown K et al (1993) Overdose of risperidone. Ann Emerg Med 22: 1908–1910

    PubMed  CAS  Google Scholar 

  • Burrows GD et al (1979) Effects of mianserin on cardiac condition. Med J Aust 2: 97–98

    PubMed  CAS  Google Scholar 

  • Campbell AJ (1991) Drug treatment as a cause of falls in old age. A review ofthe offending agents. Drugs Aging 1: 289–302

    PubMed  CAS  Google Scholar 

  • Casey DA (1994) Depression in the elderly. South Med J 87: 559–563

    PubMed  CAS  Google Scholar 

  • Ciraulo DA, Barnhill JG, Jaffe JH (1988) Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. Clin Pharmaol Ther 43: 509

    CAS  Google Scholar 

  • Closser MH (1991) Benzodiazepines and the elderly. A review of potential problems. J Subst Abuse Treat 8: 35–41

    PubMed  CAS  Google Scholar 

  • Cohen LJ (1994) Risperidone. Pharmacotherapy 14: 253–265

    PubMed  CAS  Google Scholar 

  • Cooper SM et al (1989) The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam or alcohol. Acta Psychiatr Scand 80: 53–55

    Google Scholar 

  • Coper H, Kanowski S (1983) Nootropika: Grundlagen und Therapie In: Langer G, Heimann H (eds) Pychopharmaka-Grundlagen und Therapie. Springer, Wien New York, S 409–433

    Google Scholar 

  • Crewe HK et al (1991) The effect of paroxetine and other specific serotonin re-uptake inhibitors on cytochrome P450IID6 activity in human liver microsomes. Br J Clin Pharmacol 32: 658–659

    Google Scholar 

  • Dawson ME, Schell AM, Catanca JJ (1977) Autonomic correlates of depression and clinical Improvementf ollowing electroconvulsive shock therapy. Psychophysiology 14: 569–578

    PubMed  CAS  Google Scholar 

  • De-Vanna M et al (1990) Moclobemide compared with second-generation antidepressants in elderly people. Acta Psychiatr Scand 360 [Suppl]: 64–66

    CAS  Google Scholar 

  • Demling J et al (1993) Nicht-trizyklische Antidepressiva: Interaktionen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapiehandbuch. Bd 3: Antidepressiva und Phasenprophylaktika. Springer, Wien New York, S 207–218

    Google Scholar 

  • Dewan MJ et al (1992) The use of antidepressants in the elderly: 1986 and 1989. J Geriatr Psychiatry Neurol 5: 40–44

    PubMed  CAS  Google Scholar 

  • Diamond SJ (1975) Use of a nootropic substance to increase the capacity for verbal learning and memory in normal man. In: Agnoli A (ed) Proceedings of the Symposium „Nooanaleptic and Nootropic Drugs“, 3rd Congress of the International College of Psychosomatic Median, Rome, pp 107–110

    Google Scholar 

  • Dietmaier O (1993) Trizyklische Antidepressiva: Interaktionen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuropsychoharmaka. Ein Therapiehandbuch. Bd 3: Antidepressiva und Phasenprophylaktika. Springer, Wien New York, S 72–82

    Google Scholar 

  • Dunner DL et al (1992) Two combined, multi-center doubleblind studies of paroxetine and doxepin in geriatric oatients with major depression. J Clin Psychiatry 53 [Suppl]: 57–60

    PubMed  Google Scholar 

  • Ehrly AM, Schmittner I (1976) Einfluß von Xan-tinolnicotinat auf die Fließfähigkeit von Blut in einem in vitro Kapillarsystem In: Bredin K, Gross D (Hrsg) Moderne Thromboseprophylaxe, Schattauer, Stuttgart New York, S 308–314

    Google Scholar 

  • Feighner JP et al (1983) A double-blind comparative trial with mianserin and amitriptyline in outpatients with major depressive episode. Br J Clin Pharmacol 15: 227–237

    Google Scholar 

  • Feighner JP et al (1990) Adverse consequences of fluoxetine-MAOI combination therapy. J Clin Psychiatry 51: 222–225

    PubMed  CAS  Google Scholar 

  • Fischhof PK et al (1989) Therapeutic results with nimodipine in primary degenerative dementia and multi-infarct dementia In: Bergener M, Reisberg B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York, pp 350–359

    Google Scholar 

  • Fischhof PK et al (1990) Therapieergebnisse mit Nimodipin bei primär degenerativer Demenz und Multinfarkdemenz. 2 Geriatrie 6: 320–327

    Google Scholar 

  • Fischhof PK (1991) Vincamin bei stationären Patienten mit primär degenerativer Demenz vom Alzheimer Typ bzw Multi-Infarkt-De-menz während einer 12wöchigen Behandlungsdauer (unveröffentlicht)

    Google Scholar 

  • Fischhof PK et al (1992) Therapeutic efficacy of pyritinol in patients with senile dementia of the Alzheimer’s type (SDAT) and Multinfarct Dementia (MID). Neuropsychobiology 26: 65–70

    PubMed  CAS  Google Scholar 

  • Fischhof PK (1993a) Divergent neuroprotective effects of nimodipine in PDD and MID provide indirect evidence of disturbances in Ca+2 homeostasis in dementia. Meth and Find Exptl Clin Pharmacol 8: 549–555

    Google Scholar 

  • Fischhof PK (1993b) Therapie mit Nootropika. In: Dietzel M, Dorow R, Friedmann A (eds) Psychopharmaka. 1× 1 der Psychopharmaka: Standardtherapien und neue Konzepte. Springer, Berlin Heidelberg

    Google Scholar 

  • Fitton A, Faulds D, Goa KL (1992) Moclobemide. A review of ist pharmacological properties and therapeutic use in depressive illness. Drugs 43: 561–596

    PubMed  CAS  Google Scholar 

  • Foy A et al (1995) Benzodiazepine use as a cause of cognitive impairment in elderly hospital inpatients. J Gerontol A Biol Sci Med Sci 50: 99–106

    Google Scholar 

  • Fritze J, Laux G (1993) Trizyklische Antidepressiva: unerwünschte Wirkungen, Kontraindikationen, Überdosierung, Intoxikationen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neu-ropsychopharmaka. Ein Therapiehandbuch. Bd 3: Antidepressiva und Phasenprophylaktika. Springer, Wien New York, S 59–71

    Google Scholar 

  • Giurgea C (1976) Piracetam: nootropic pharmacology of neurointegrative activity. Current Developments in Psychopharmacology, vol 3. Spectrum, New York, pp 223–273

    Google Scholar 

  • Goodwin FK, Prange AJ, Post RM (1982) Potentiation of antidepressant effect by L-trijodo-thyronine in tricyclic nonresponders. Am J Psychiatry 139: 34–38

    PubMed  CAS  Google Scholar 

  • Gram LF et al (1993) Citalopram: Interaction studies with levopromazine, imipramine, and lithium. Ther Drug Monit 15: 18–24

    PubMed  CAS  Google Scholar 

  • Greenblatt DJ, Harmatz JS, Shader RI (1991) Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (part I). Clin Pharmacokinet 21: 165–177

    PubMed  CAS  Google Scholar 

  • Grimsley SR et al (1991) Increased carbamazepine plasma concentrations after fluoxetine coadministration. Clin Pharmacol Ther 50: 10–15

    PubMed  CAS  Google Scholar 

  • Grundye E, Bowling A (1991) The sociology of ageing. In: Jacoby R, Oppenheimer C (eds) Psychiatry in the elderly. Oxford University Press, Oxford New York Tokyo, pp 35–57

    Google Scholar 

  • Grüter W, Pöldinger W (1982) Maprotiline. Mod Probi Pharmacopsychiatry 18: 1–30

    Google Scholar 

  • Halper JP, Mann JJ (1990) Cardiovascular effects of antidepressant medications. Brit J Psychiatry 153: 87–98

    Google Scholar 

  • Hart RP, Cclenda CC, Hamer RM (1991) Effects of buspirone and alprazolam on the cognitive performance of normal elderly subjects. Am J Psychiatry 148: 73–77

    PubMed  CAS  Google Scholar 

  • Henauer SA, Hollister LE (1984) Cimetidine interaction with imipramine and nortriptyline. Clin Pharmacol Ther 35: 183–185

    PubMed  CAS  Google Scholar 

  • Herrmann WM, Kern U (1987) Nootropica: Wirkungen und Wirksamkeit. Eine Überlegung am Beispiel einer Phase II-Prüfung mit Piracetam. Nervenarzt 58: 358–364

    PubMed  CAS  Google Scholar 

  • Herrmann WM, Kern U, Röhmel J (1986) On the effects of pyritinol on functional deficits of patients with organic mental disorder. Phar-macopsychiatr 19: 378–385

    CAS  Google Scholar 

  • Herrschaft H (1974) Die Bedeutung regionaler Hirndurchblutung für die Diagnostik und Therapie der zerebralen Durchblutungsstörungen. 2 Therapiewoche 28: 1–10

    Google Scholar 

  • Hetzel W (1992) Neueste Angaben über die klinische Verträglichkeit von Moclobemid: Suizide, Intoxikationen und Nebenwirkungen. 3. Int. Moclobemid-Symposium, Wien, 29.-31. 3. 1992. Abstracts, S 7

    Google Scholar 

  • Hohagen F et al (1994) Prevalence of insomnia in elderly general practice attenders and the current treatment modalities. Acta Psychiatr Scand 90: 102–108

    PubMed  CAS  Google Scholar 

  • Holzer JC, Guelman DR, Price BH (1995) Efficacy of buspirone in the treatment of dementia with aggression. Am J Psychiatry 152: 812

    PubMed  CAS  Google Scholar 

  • Janowsky DD et al (1972) A cholinergic-adrenergic hypothesis of mania and depression. Lancet 23: 632–635

    Google Scholar 

  • Jarvis MR (1991) Clinical pharmacokinetics of tricyclic antidepressant overdose. Psycho-pharmacol Bull 27: 541–550

    CAS  Google Scholar 

  • Jellinger K (1983) Psychopharmakatherapie beim alten Menschen. In: Langer G, Heimann H (Hrsg) Psychopharmaka: Grundlagen und Therapie. Springer, Wien New York, S 591–613

    Google Scholar 

  • Jenike MA (1985) Handbook of geriatric psycho-pharmacology. PSG Publishing, Littleton

    Google Scholar 

  • Jeste DV, Wyatt RJ (1987) Aging and tardive dyskinesia. In: Miller NE, Cohen GD (eds) Schizophrenia and aging. Guilford, New York

    Google Scholar 

  • Jori A, Annoni F, Bianchetti A (1968) Metabolic effects induced by the interaction of reserpine with desipramine. J Pharm Pharmacol 20: 862–866

    PubMed  CAS  Google Scholar 

  • Kanowski S et al (1990) Efficacy of xantinolnico-tinate in patients with dementia. Pharmako-psychiat 23: 118–124

    CAS  Google Scholar 

  • Kanowski S et al (1988) Wirksamkeitsnachweis von Nootropika am Beispiel von Nimodipin-ein Beitrag zur Entwicklung geeigneter klinischer Prüfmodelle. Z Gerontopsychol-psychiatr 1: 35–44

    Google Scholar 

  • Kirven LE, Montero EF (1973) Comparison of thioridazine and diazepam in the control of nonpsychotic symptoms associated with senility: double-blind control study. Am J Geriatr Soc 21: 545–551

    Google Scholar 

  • Klein-Schwartz W, Oderda GM (1991) Poisoning in the elderly. Epidemiological, clinical and management considerations. Drugs Aging 1: 67–89

    PubMed  CAS  Google Scholar 

  • Koch-Weser J, Sellers EM (1971) Drug interactions with coumarin anticoagulants. N Engl J Med 285: 547–558

    CAS  Google Scholar 

  • Kraus MF, Burch EA (1992) Methylphanidate hydrochloride as an antidepressant: controversy, case studies and review. South Med J 85: 985–991

    PubMed  CAS  Google Scholar 

  • Krieglstein J (1990) Hirnleistungsstörungen-Pharmakologie und Ansätze für die Therapie. Wiss. Verlagsges., Stuttgart

    Google Scholar 

  • Kruse WH (1990) Problems and pitfalls in the use of benzodiazepiens in the elderly. Drg Saf 5: 328–344

    CAS  Google Scholar 

  • Ladurner G (1991) DieTherapie des ischämischen Insultes und der chronischen zerebrovasku-lären Insuffiziens. In: Ladurner G (Hrsg) Die zerebrovaskuläre Insuffizienz. Zuckschwerdt, München, S 69–90

    Google Scholar 

  • Landauer AA, Milner G, Patman J (1969) Alcohol and amitriptyline effects on skills related to drivingbehavior. Science 63:1467

    Google Scholar 

  • Landfield PW (1989) Calcium homeostasis in brain aging and Alzheimer’s disease. In: Bergener M, Reisberg B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York, pp 276–287

    Google Scholar 

  • Langer G, Schönbeck G (1983) Klinische Pharmakologie der Antidepressiva. In: Langer G, Heimann H (Hrsg) Psychopharmaka: Grundlagen und Therapie. Springer, Wien New York, S 96–110

    Google Scholar 

  • Lasswell WL, Weber SS, Wilkins JM (1984) In vitro interaction of neuroleptics and tricyclic antidepressants with coffee, tea and gallotanic acid. J Pharm Sci 73: 1056–1058

    PubMed  CAS  Google Scholar 

  • Learoyd DM (1972) Toxic drug reactions in the elderly. Med J Aust I: 1131–1133

    Google Scholar 

  • Lehofer M et al (1995) Effect of Tricyclic antidepressants on cardiac vagal tone related to age (im Druck)

    Google Scholar 

  • Lemberger L et al (1988) The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam. Clin Pharmacol Ther 43: 412–419

    PubMed  CAS  Google Scholar 

  • Liljequist R, Seppala T, Mattilya MJ (1978) Amitriptyline-and mianserin-induced changes in acquisition of paired-association learning task. Br J Clin Pharmacol 5: 149–153

    PubMed  CAS  Google Scholar 

  • Linnoila M, George L, Guthrie S (1982) Interactions between antidepressants and perphenazine in psychiatric inpatients. Am J Psychiatry 139: 1329–1331

    PubMed  CAS  Google Scholar 

  • Lohner H et al (1993) Therapie von Depressionen durch Manipulation des Schlaf-Wachrhythmus. In: Peter JH et al (Hrsg) Der therapeutische Fortschritt in der Schlafmedizin. Wien Med Wochenschr 144: 26–31

    Google Scholar 

  • Lohr JB et al (1993) Treatment of disordered behavior. In: Salzman C (ed) Clinical geriatric psychopharmacology, 2nd edn. Williams & Wilkins, Baltimore Tokyo, pp 79–113

    Google Scholar 

  • Luo H, Richardson JS (1993) A pharmacological comparison of Citalopram, a bicyclic serotonin uptake inhibitor, with traditional tricyclic antidepressants. Int Clin Psychopharmacol 8: 3–12

    PubMed  CAS  Google Scholar 

  • Maczaj M (1993) Pharmacological treatment of insomnia. Drugs 45: 44–55

    PubMed  CAS  Google Scholar 

  • Maguire K, Pereira A, Tiller J (1991) Moclobemi-de pharmacokinetics in depressed patients: lack of age effect. Hum Psychopharmacol 6: 249–252

    Google Scholar 

  • McDonald RJ (1982) Drug treatment of senile dementia. In: Wheathley D (ed) Psychophar-macology of old age. Chapter 9. Oxford University Press, Oxford

    Google Scholar 

  • Mendlewicz J (1984) Acute and chronic effects of mianserin on sleep EEG architecture. Clin Neuropharmacol 7: 638–639

    Google Scholar 

  • Montgomery SA, Bullock T, Pinder RM (1991) The clinical profile of mianserin. Nord Psykiatr Tidsskr 45: 27–35

    Google Scholar 

  • Murphy JE (1978) Mianserin in the treatment of depressive illness and anxiety states in general practice. Br J Clin Pharmacol 5: 81–82

    Google Scholar 

  • Nair NPV et al (1995) Reversible and selective inhibitors of monoamine oxidase a in the treatment of depressed elderly patients. Acta Psychiatr Scand 91 [Suppl 386]: 28–35

    Google Scholar 

  • Napoliello MJ, Domantay AG (1991) Buspirone: a world-wide update. Br J Psychiatry 12 [Suppl]: 40–44

    Google Scholar 

  • NIH Consensus Development Conference Statement (1993) Diagnosis and treatment of depression in late life. Psychopharmacol Bull 29: 87–100

    Google Scholar 

  • Old Age Depression Interest Group (1993) How long should the elderly take antidepressants? A double blind placebo-controlled study of continuation/prophylaxis therapy with do-thiepin. Br J Psychiatry 162: 175–182

    Google Scholar 

  • Olson KR et al (1994) Seizures associated with poisoning and drug overdose. Am J Emerg Med 11: 565–568

    Google Scholar 

  • Owens DG (1994) Extrapyramidal side effects and tolerability of risperidone: a review. J Clin Psychiatry 55 [Suppl]: 29–35

    PubMed  Google Scholar 

  • Petor R et al (1988) Randomized trial of prophylactic daily aspirin. Br Med J 296: 313–316

    Google Scholar 

  • Peyramond A (1978) Ètude comparative croisée del’action du tiapride et du méprobamate sur les états d’agitation. Semaine des Hôpitaux 54: 542–545

    PubMed  CAS  Google Scholar 

  • Phanjoo A (1991) The elderly depressed and treatment with fluvoxamine. Int Clin Psychopharmacol 6 [Suppl 3]: 33–37

    PubMed  Google Scholar 

  • Pöch G, Juan H (1990) Wirkungen von Pharmaka. 2. neubearbeitete und erweiterte Auflage. Thieme, Stuttgart New York

    Google Scholar 

  • Pomara N et al (1984) Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentration. Psychopharma-cology 84: 342–346

    CAS  Google Scholar 

  • Postma JU, Vranesic D (1983) Moclobemide in the treatment of depression in demented geriatric patients. Arch Ther 11: 1–4

    Google Scholar 

  • Raemakers JG, Swijgman HF, O’Hanlon JF (1992) The effect of moclobemide and mianserine on highway driving, psychometric performance and subjective parameters, relative to placebo. Psychopharmacology 106 [Suppl]: 562–567

    Google Scholar 

  • Ray WA et al (1987) Psychotropic drug use and the risk of hip fracture. N Engl J Med 316: 363–369

    PubMed  CAS  Google Scholar 

  • Ray WA, Fought RL, Decker MD (1992) Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. Am J Epidemiol 136 (7): 873–883

    PubMed  CAS  Google Scholar 

  • Ray WA, Thapa PB, Shorr RI (1993) Medications and the older driver. Clin Geriatr Med 9: 413–438

    PubMed  CAS  Google Scholar 

  • Razani J et al (1983) The safety and efficacy of combined amitriptyline and tranylcypromine antidepressant treatment. Arch Gen Psychiatry 40: 657–661

    PubMed  CAS  Google Scholar 

  • Regestein QR (1992) Treatment of insomnia in the elderly. In: Salzman C (ed) Clinical geriatric psychopharmacology, 2nd edn. Williams & Wilkins, Baltimore Tokyo, pp 235–253

    Google Scholar 

  • Rickels K (1990) Buspirone in clinical practice. J Clin Psychiatry 51 [Suppl]: 51–54

    PubMed  Google Scholar 

  • Rickels K, Schweizer E, Lucki I (1987) Benzodiazepine side effects. In: Psychiatryupdate: American Psychiatric association annual review, vol 6. American Psychiatric Press, Washington DC, pp 781–801

    Google Scholar 

  • Robbe HWJ, Shoenmakers EAMJ, O’Hanlon JF (1989) Acute and subchronic effects of paroxetine and amitriptyline on psychomotor and driving performance. 8th World Congress of Psychiatry, Athens

    Google Scholar 

  • Rouquet JP, Bezaury JP (1984) Traitment de l’agitation dans les états démentiels. Ètude comparative, en ouvert, de l’action du tiapride et du lorazepam. Semaine des Hôpitaux 60: 3068–3088

    Google Scholar 

  • Ryyanen OP et al (1993) Medication and chronic diseases as risk factors for falling injuries in the elderly. Scand J Soc Med 21: 264–271

    Google Scholar 

  • Salama AA, Shafey M (1989) A case of severe lithium toxicity induced by combined fluoxetine and lithium carbonate. Am J Psychiatry 146: 278

    PubMed  CAS  Google Scholar 

  • Saletu B (1986) Neurophysiologische Aspekte des normalen und pathologischen Alterns und der Gerontopharmakologie In: Lauter H, Möller HJ, Zimmer R (Hrsg) Untersuchungsund Behandlungsverfahren in der Geronto-psychiatrie. Springer, Berlin Heidelberg, S 168–188

    Google Scholar 

  • Salzman C (1990) Anxiety in the elderly: treatment strategies. J Clin Psychiatry 51 [Suppl]: 18–21

    PubMed  Google Scholar 

  • Salzman C (1992) Treatment of anxiety. In: Salzman C (ed) Clinical geriatric psychopharma-cology, 2nd edn. Williams & Wilkins, Baltimore Tokyo, pp 189–212

    Google Scholar 

  • Salzman C (1993) Pharmacologic treatment of depression in the elderly. J Clin Psychiatry 54: 23–28

    PubMed  Google Scholar 

  • Salzman C, Shader RI, Pearlman M (1970) Psychopharmacology and the ederly. In: Shader RI, DiMascio A (eds) Psychotropic drug side effects. Williams & Wilkins, Baltimore

    Google Scholar 

  • Schatzberg AF, Cole JO (1991) Manual of clinical psychopharmacology, 2nd edn. American Psychiatric Press, Washington London

    Google Scholar 

  • Schifano F et al (1990) A double blind comparison of mianserin and maprotiline in depressed medically ill elderly people. Acta Psychiatr Scand 81: 289–294

    PubMed  CAS  Google Scholar 

  • Schöny W (1992) Die Wirksamkeit und Verträglichkeit von Citalopram im Vergleich von parenteraler und oraler Verabreichung. Neuropsychiatrie 6: 65–71

    Google Scholar 

  • Schöny W, Rittmannsberger H (1992) Praktische Durchführung, allgemeine Behandlungsrichtlinien. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuropsychoharmaka. Ein Therapiehandbuch. Bd 4: Neuroleptika. Springer, Wien New York, S 129–152

    Google Scholar 

  • Schuckit M, Robins E, Feighner J (1971) Tricyclic antidepressant and monoamine oxidase inhibitors. Combination therapy in the treatment of depression. Arch Gen Psychiatry 24: 509–514

    PubMed  CAS  Google Scholar 

  • Sepälla T, Stromberg C, Bergmann I (1984) Effects of zimeldine, mianserin and amitripty-line on psychomotor skills and their interaction with ethanol. Eur J Clin Pharmacol 27: 181–189

    Google Scholar 

  • Seppala M et al (1993) Midazolam and flunitraze-pam: pharmacocinetics and effects on night time respiration and body movements in the elderly. Int J Clin Pharmacol Ther Toxicol 31: 170–176

    PubMed  CAS  Google Scholar 

  • Shimizu M et al (1985) A multicentre, double-blind comparative study of tiapride and chlorpromazine in patients with psychiatric disorders of the aged (Translation from Japanese — Jap J Clinical Psychiatry) Rinsho Seishin Igaku 27: 573–582

    Google Scholar 

  • Shorr RI, Robin DW (1994) Rational use of benzodiazepines in the elderly. Drugs Aging 4: 9–20

    PubMed  CAS  Google Scholar 

  • Sizaret P, Walker SE, Mackenzie S (1974) Clinical investigation of lorazepam. Psychol Med 6: 591–598

    Google Scholar 

  • Smith DA, Perry PJ (1992) Non-neuroleptic treatment of disruptive behavior in organic mental syndromes. Ann Pharmacother 26: 1400–1408

    PubMed  CAS  Google Scholar 

  • Spiker DG, Pugh DD (1976) Combining tricyclic and monoamine oxidase inhibitor antidepressants. Arch Gen Psychiatry 33: 828–830

    PubMed  CAS  Google Scholar 

  • Steele JW, Faulds D, Sorkin EM (1993) Tiaprid: a review of ist pharmacodynamic and pharmacokinetic properties and therapeutic potential in geriatric agitation. Drugs & Aging 3: 460–478

    CAS  Google Scholar 

  • Steinberg JR (1994) Anxiety in elderly patients. A comparison of azaspirones and benzodiazepines. Drugs & Aging 5: 335–345

    CAS  Google Scholar 

  • Steiner W, Fontaine R (1986) Toxic reaction following the combined administration of fluoxetine and L-tryptophane: five case reports. Biol Psychiatry 21: 53–58

    Google Scholar 

  • Sternbach H (1988) Danger of MAOI therapy after fluoxetine withdrawal. Lancet, pp 850–851

    Google Scholar 

  • Stoeckel K, Pfefen JP, Mayersohn M (1990) Absorption and disposition of moclobemide in patients with advanced age or reduced liver and kidney function. Acta Psychiatr Scand 82 [Suppl 360]: 94–97

    Google Scholar 

  • Sutherland DL et al (1987) The influnece of cimetidine versus ranitidine on doxepin pharmacokinetics. J Clin Psychopharmacol 32: 159–164

    CAS  Google Scholar 

  • Swantek SS et al (1991) The use of carbamazepine to treat benzodiazepine withdrawal in a geriatric population. J Geriatr Psychiatry Neurol 4: 106–109

    PubMed  CAS  Google Scholar 

  • Vaughan DA (1988) Interaction of fluoxetine with tricyclic antidepressants. Am J Psychiatry 145: 1478

    PubMed  CAS  Google Scholar 

  • Vesell ES (1970) Impairment of drug metabolism in man by allopurinol and nortryptilyne. N Engl J Med 283: 1484

    PubMed  CAS  Google Scholar 

  • Watsky E, Salzman C (1992) Psychotropic drug dosage and drug interactions. In: Salzman C (ed) Clinical geriatric psychopharmacology, 2nd edn. Williams & Wilkins, Baltimore Tokyo, pp 303–331

    Google Scholar 

  • Weber E (1991) Taschenbuch der unerwünschten Arzneiwirkungen. Fischer, Stuttgart

    Google Scholar 

  • Weil C (1988) Hydergin, pharmakologische und klinische Befunde. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Weiss H (1989) Wirksamkeit des Gingko biloba Extraktes (EGb-76l) bei Hirnleistungsstörungen. Münch Med Wochenschr 131 [Beilage 82]: 6

    Google Scholar 

  • Wells BG, Gelenberg AJ (1981) Chemistry, pharmacology, pharmacokinetics, adverse effects and efficacy ofthe antidepressant ma-protiline hydrochloride. Pharmacotherapy 1: 121–142

    PubMed  CAS  Google Scholar 

  • Wester HA, Siegers CP (1980) Cardiovaskular effects of mianserin and amitriptyline in healthy volunteers. Curr Med Res Opin 6: 29–35

    CAS  Google Scholar 

  • Wood P, Castleden CM (1991) Psychopharma-cology in the elderly. In: Jacoby R, Oppen-heimer C (eds) Psychiatry in the elderly. Oxford University Press, Oxford New York Tokyo, pp 339–372

    Google Scholar 

  • Wragg RE, Jeste DV (1988) Neuroleptics and alternative treatments: management of behavioral symptoms and psychosis in Alzheimer’s disease and related conditions. Psychiatr Clin North Am 11: 195–213

    PubMed  CAS  Google Scholar 

  • Young RC, Meyers BS (1991) Psychopharmacology. In: Sadavoy LW, Jarvik LF (eds) Comprehensive review of geriatric psychiatry. American Psychiatric Press, Washington DC, pp 435–468

    Google Scholar 

  • Zimmer R et al (1990) Interaction studies with moclobemide. Acta Psychiatr Scand 82 [Suppl 360]: 84–86

    Google Scholar 

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Hofmann, P., Fischhof, P.K., Zapotoczky, H.G. (1996). Psychopharmakotherapie. In: Zapotoczky, H.G., Fischhof, P.K. (eds) Handbuch der Gerontopsychiatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6563-8_20

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