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Structure and function of rotavirus NSP1

  • K. Taniguchi
  • K. Kojima
  • N. Kobayashi
  • T. Urasawa
  • S. Urasawa
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 12)

Summary

Studies on the structure and function of the nonstructural proteins (NSP1-NSP5) of rotaviruses are important for dissection of the morphogenesis and replication processes of rotavirus. Above all, NSP1, the product of gene 5, has several interesting features, such as extreme sequence diversity, a highly conserved cysteine-rich region, RNA-binding activity, accumulation on the cytoskeleton, and non-random segregation in reassortment. Recently, comparable NSP1 sequence analysis has been performed on a number of rotavirus strains from various species. Furthermore, characterization of mutants with rearranged NSP1 genes has helped to elucidate the structure-function interaction of NSP1. We isolated and characterized two interesting mutants which have a large deletion including the cysteine-rich region or a nonsense codon at the early portion in the open reading frame (ORF) of the NSP1 gene. In this report, we summarize the structure and function of NSP1.

Keywords

NSP1 Gene Nonsense Codon Extreme Sequence Diversity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1996

Authors and Affiliations

  • K. Taniguchi
    • 1
  • K. Kojima
    • 1
  • N. Kobayashi
    • 1
  • T. Urasawa
    • 1
  • S. Urasawa
    • 1
  1. 1.Department of HygieneSapporo Medical University School of MedicineChuo-ku, Sapporo 060Japan

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