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Structural features unique to enteric adenoviruses

  • Conference paper
Viral Gastroenteritis

Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 12))

Summary

Enteric adenoviruses are important agents of pediatric gastroenteritis. Characterization of monoclonal antibodies against human adenovirus 41 (h-41) identified an epitope of interest on protein VI, an internal virion protein. The epitope is common to enteric adenoviruses (subgenus A: h-12, h-18, h-31 and subgenus F: h-40, h-41) but is not shared by non-enteric serotypes (subgenera B, C, D or E). By expressing random oligonucleotide fragments of the protein VI gene as T7 gene 10 fusion proteins in the pTope vector (Novagen), the epitope was mapped within the central domain of protein VI, to the region corresponding to aa 114-125 of the Ad2 protein. Identification of this epitope reflects the close evolutionary relationship of subgenus A and subgenus F adenoviruses and draws attention to structural features of enteric adenoviruses as potential determinants of tropism. Furthermore, this epitope may be valuable for identification of enteric adenoviruses in clinical specimens.

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Author information

Authors and Affiliations

  1. Department of Microbiology, University of Toronto, Toronto, Ontario, Canada

    Dr. M. Brown, J. D. Grydsuk, E. Fortsas & M. Petric

  2. Department of Microbiology, The Hospital for Sick Children, Toronto, Ontario, Canada

    M. Petric

  3. Department of Medical Genetics, University of Toronto, Fitz Gerald Building, 150 College St., Toronto, Ontario, M5S 1A8, Canada

    Dr. M. Brown

Authors
  1. Dr. M. Brown
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  2. J. D. Grydsuk
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  3. E. Fortsas
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  4. M. Petric
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Editor information

Editors and Affiliations

  1. Sapporo Medical University, Sapporo, Japan

    Shunzo Chiba  & Shuji Nakata  & 

  2. Baylor College of Medicine, Houston, USA

    Mary K. Estes

  3. Colorado State University, Fort Collins, USA

    Charles H. Calisher

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© 1996 Springer-Verlag Wien

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Brown, M., Grydsuk, J.D., Fortsas, E., Petric, M. (1996). Structural features unique to enteric adenoviruses. In: Chiba, S., Estes, M.K., Nakata, S., Calisher, C.H. (eds) Viral Gastroenteritis. Archives of Virology, vol 12. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6553-9_32

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  • DOI: https://doi.org/10.1007/978-3-7091-6553-9_32

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82875-5

  • Online ISBN: 978-3-7091-6553-9

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