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WC3 reassortant vaccines in children

Brief review

  • Conference paper
Viral Gastroenteritis

Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 12))

Summary

Bovine rotavirus strain WC3 (P7[5], G6) administered at the 12th passage level was well tolerated clinically in infants and efficiently induced serum virus neutralizing antibody (VNA) with bovine rotavirus G6 specificity. The protective efficacy of WC3 vaccine against all rotavirus disease was inconsistent, varying in four separate trials from 76% to 0%; some selective protection against severe disease was seen in all trials. WC3 reassortants containing the gene for an individual human rotavirus VP7 (G) or VP4 (P) surface antigen were also well tolerated, but preferentially induced VNA to the WC3 parent. Efficacy trials of human G1 VP7 reassortant WI79-9 (P7[5], G1) consistently led to >60% protection against all rotavirus disease. A quadrivalent WC3 reassortant vaccine was developed to contain four separate monovalent reassortants expressing human rotaviruses surface proteins G1, G2, G3, and P1A [8] respectively. In a multicenter trial including 439 infants, this vaccine induced 67.1% protection against all rotavirus disease (defined as positive for rotavirus antigen by ELISA only [p= <0.001]) and 72.6% protection when the standard for rotavirus diagnosis was a positive test of stool for both rotavirus antigen by ELISA and rotavirus RNA by electropherotype analysis (p = < 0.001). In this trial, episodes of the most severe rotavirus disease (clinical severity score > 16.0, eight cases) occurred only in placebo recipients.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Pennsylvania, Philadelphia, USA

    Dr. H. F. Clark & P. A. Offit

  2. Merck Research Laboratories, West Point, PA, USA

    R. W. Ellis, D. Krah, A. R. Shaw & J. J. Eiden

  3. School of Medicine, University of Rochester, New York, USA

    M. Pichichero & J. J. Treanor

  4. Division of Infectious Diseases, Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, Pennsylvania, 19104, USA

    Dr. H. F. Clark

Authors
  1. Dr. H. F. Clark
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  2. P. A. Offit
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  3. R. W. Ellis
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  4. D. Krah
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  5. A. R. Shaw
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  6. J. J. Eiden
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  7. M. Pichichero
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  8. J. J. Treanor
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Editor information

Editors and Affiliations

  1. Sapporo Medical University, Sapporo, Japan

    Shunzo Chiba  & Shuji Nakata  & 

  2. Baylor College of Medicine, Houston, USA

    Mary K. Estes

  3. Colorado State University, Fort Collins, USA

    Charles H. Calisher

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© 1996 Springer-Verlag Wien

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Clark, H.F. et al. (1996). WC3 reassortant vaccines in children. In: Chiba, S., Estes, M.K., Nakata, S., Calisher, C.H. (eds) Viral Gastroenteritis. Archives of Virology, vol 12. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6553-9_20

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  • DOI: https://doi.org/10.1007/978-3-7091-6553-9_20

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82875-5

  • Online ISBN: 978-3-7091-6553-9

  • eBook Packages: Springer Book Archive

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