Viral factors determining rotavirus pathogenicity

  • U. Desselberger
Conference paper


The pathogenicity of rotaviruses depends on multiple viral and host factors. Evidence is presented for the involvement of a number of viral genes (coding for structural and non-structural proteins) in the ability of the virus to cause diarrhoea. Different genes are important in different rotavirus-host systems suggesting that there is no single viral pathogenicity factor.


Outer Capsid Protein Host Range Restriction Gnotobiotic Piglet 
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Copyright information

© Springer-Verlag Wien 1997

Authors and Affiliations

  • U. Desselberger
    • 1
  1. 1.Clinical Microbiology and Public Health LaboratoryAddenbrooke’s HospitalCambridgeUK

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