Sesquiterpenoids from Thapsia Species and Medicinal Chemistry of the Thapsigargins

  • S. B. Christensen
  • A. Andersen
  • U. W. Smitt
Part of the Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products book series (FORTCHEMIE (closed), volume 71)


For centuries preparations containing resin from the root of Thapsia garganica L. (Fig. 1) have been used in Arabian and European medicine for treatment of pulmonary diseases, catarrh and as counterirritants for relief of rheumatic pains (1). The properties of the resin were described already by Theophrastos (372-287 B.C.), Dioscorides (approximately a.d. 50), and Plinius (A.D. 24–79) (2). Radix Thapsiae and Resina Thapsiae have been included in several pharmacopoeias, the latest in the French pharmacopoeia from 1937.


Thionyl Chloride SesqUiterpene Lactone Cyclopiazonic Acid Geranyl Acetate Selective Hydrolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1997

Authors and Affiliations

  • S. B. Christensen
    • 1
  • A. Andersen
    • 1
  • U. W. Smitt
    • 1
  1. 1.Department of Medicinal ChemistryRoyal Danish School of PharmacyCopenhagenDenmark

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