Skip to main content

Part of the book series: Acta Neurochirurgica Supplements ((STEREOTACTIC,volume 68))

Abstract

Posteroventral pallidotomy (PVP) has gained a worldwide acceptance after its reintroduction by Laitinen et al. in 1992 (56) and many studies have since been published. A review of the recent literature reveals that there is variation in the clinical indications for this procedure, the surgical technique used and the assessment of results. There is no uniform practice in the choice of the anatomical target point within the globus pallidus, the imaging of the target structure, the intraoperative assessment of the physiological target and the mode of evaluation of the surgical results. Although some neurosurgeons advocate that the lesion should be in the lateral pallidum, the majority insist it should be in the medial pallidum. It is shown here that, as long as the lesion is made at the posterior and ventral parts of the globus pallidus, it will necessarily include aspects of both medial and lateral posteroventral pallidum. There is a common agreement on the effectiveness of pallidal surgery on the L-dopa induced dyskinesias, but, its long-term effects on tremor, akinesia, freezing of the gait and other genuine parkinsonian symptoms need more extensive evaluation. The assessment of the outcome of pallidal surgery in terms of the patient’s disability, quality of life and coping abilities following surgery seems to have been neglected.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12: 366–375

    Article  PubMed  CAS  Google Scholar 

  2. Alterman RL, Kall BA, Cohen H, Kelly PJ (1995) Stereotactic ventrdateral thalamotomy: Is ventriculography necessary? Neurosurgery 37: 717–722

    Article  PubMed  CAS  Google Scholar 

  3. Alterman R, Kelly P, Beric A, Eidelberg D, Fazzini E, Perrine K, Sterio D (1996) Selection criteria for posteroventral pallidotomy (Abstract). Acta Neurochir (Wien) 138: 636

    Google Scholar 

  4. Barcia-Salorio JL, Pascual-Leone A, Barcia JA, Garcia-March G, López-Gómez L, Roldán P, Llácer JL (1996) Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) and of the nucleus ventro-oralis posterior (Vop) in movement disorders. (Abstract) Acta Neurochir (Wien) 138: 637

    Google Scholar 

  5. Benabid AL, Pollak P, Gross C, Hoffman D, Benazzouz A, Gao DM, Laurent A, Gentil M, Perret J (1994) Acute and long-term effects of subthalamic nucleus stimulation in Parkinson’s disease. Stereotact Funct Neurosurg 62: 76–84

    Article  PubMed  CAS  Google Scholar 

  6. Benabid AL, Pollak P, Gervason C, Hoffmann D, Gao DM, Hommel M, Perret JE, De Rougemont J (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337: 403–406

    Article  PubMed  CAS  Google Scholar 

  7. Blanchet PJ, Boucher R, Bedard PJ (1994) Exeitotoxic lateral pallidotomy does not relieve L-dopa induced dyskinesia in MPTP parkinsonian monkeys. Brain Res 650: 32–39

    Article  PubMed  CAS  Google Scholar 

  8. Brown RG, MacCarthy B, Jahanshahi M, Marsden CD (1989) Accuracy of self-reported disability in patients with Parkinsonism. Arch Neurol 46: 955–959

    Article  PubMed  CAS  Google Scholar 

  9. Burchiel KJ, Favre J, Taha J (1996) Pallidotomy for Parkinson’s disease: surgical technique and results (abstract). J Neurosurg 84: 336A

    Google Scholar 

  10. Burzaco J (1985) Stereotactic pallidotomy in extrapyramidal disorders. Appl Neurophysiol 48: 283–287

    PubMed  CAS  Google Scholar 

  11. De Lotbinière ACJ (1996) Microelectrode recording: essential for the optimal placement of radiofrequency pallidotomy? (Abstract). Acta Neurochir (Wien) 138: 636

    Google Scholar 

  12. DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13: 281–285

    Article  PubMed  CAS  Google Scholar 

  13. DeSalles AAF, Brekhus SD, DeSouza EC, Behnke EJ, Farahani K, Anzai Y, Lufkin R (1995) Early postoperative appearance of radiofrequency lesions on magnetic resonance imaging. Neurosurgery 36: 932–937

    Article  CAS  Google Scholar 

  14. DeSalles AAF, Behnke E, Bronstein J, Masteman D, Vassilev V, Cabatan-Awang C, Medin P (1996) MRI guided pallidotomy and acute radiofrequency lesion aspect (abstract). Acta Neurochir (Wien) 138: 642

    Google Scholar 

  15. DeSalles AAF, Hariz M (1993) Functional Radiosurgery. In: DeSalles AAF, Goetsch S (eds) Stereotactic surgery and radiosurgery. Medical Physics Publishing, Madison, Wisconsin, pp 389–406

    Google Scholar 

  16. Dogali M, Beric A, Sterio D, Eidelberg D, Fazzini S, Takikawa S, Samelson DR, Devinski O, Kolodny EH (1995) Anatomic and physiologic considerations in pallidotomy for Parkinson’s disease. Acta Neurochir (Wien) [Suppl] 64: 9–12

    Article  CAS  Google Scholar 

  17. Dogali M, Fazzini E, Kolodny E, Eidelberg D, Sterio D, Devinski O, Beric A (1995) Stereotactic ventral pallidotomy for Parkinson’s disease. Neurology 45: 753–761

    Article  PubMed  CAS  Google Scholar 

  18. Eidelberg D, Mocller JR, Ishikawa T, Dhawan V, Spetsieris P, Silbersweig D, Stern E, Woods RP, Fazzini E, Dogali M, Beric A (1996) Regional metabolic correlates of surgical outcome following unilateral pallidotomy for Parkinson’s disease. Ann Neurol 39: 450–459

    Article  PubMed  CAS  Google Scholar 

  19. Eidelberg D, Takikawa S, Moeller JR, Dhawan V, Redington K, Chaly T, Robeson W, Dahl JR, Margouleff D, Fazzini E, Przedborski S, Fahn S (1993) Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson’s disease. Ann Neurol 33: 518–527

    Article  PubMed  CAS  Google Scholar 

  20. Fahn S, Elton RL Members of the UPDRS Development Committee (1987) Unitied Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M, (eds) Recent developments in Parkinson’s disease, vol 2. Macmillan Health Care Information, Florham Park, NJ, pp 153–163

    Google Scholar 

  21. Fazzini E, Dogali M, Berich A, Chin L, Eidelberg D, Sterio G, Samelson D, Loftus S, Gianutsos B, Newman B, Kolodny E, Laitinen L (1993) Ventral pallidotomy operations in patients with Parkinson’s plus syndromes (abstract). Ann Neurol 34: 266

    Google Scholar 

  22. Fazzini E, Dogali M, Eidelberg D, Beric A, Sterio G, Perrine K, Kolodny E (1996) Three-year follow up following unilateral pallidotomy in Parkinson’s disease (abstract). Neurology 46: A200

    Google Scholar 

  23. Filion M, Boucher R, Bedard P (1985) Globus pallidus unit activity in the monkey during the induction of parkinsonism by l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Soc Neurosci Abstr 11: 1160

    Google Scholar 

  24. Friedman JH, Epstein M, Sanes JN, Lieberman P, Cullen K, Lindquist C, Daamen M (1996) Gamma knife pallidotomy in advanced Parkinson’s disease. Ann Neurol 39: 535–538

    Article  PubMed  CAS  Google Scholar 

  25. Frichs GM, Norén GC (1996) Neurosurgical treatment of parkinsonism with the Leksell Gamma Knife (abstract). Mov Disord 11[Suppl 1]:242

    Google Scholar 

  26. Galvéz-Jiménez N, Lozano AM, Duff J, Trépanier L, Saint-Cyr JA, Lang AE (1996) Bilateral pallidotomy: pronounced amelioration of incapacitating levodopa-induced dyskinesias but accompanying cognitive decline (abstract). Mov Disord 11[Suppl 1]: 242

    Google Scholar 

  27. Galvéz-Jiménez N, Lang AE, Lozano A, Tasker R, Duff J, Hutchinson W, Ashby P, Dostrovsky O (1996) Deep brain stimulation in Parkinson’s disease: new methods of tailoring functional surgery to patient needs and response (abstract). Neurology 46: A402

    Google Scholar 

  28. Ghika J, Favre J, Frankhauser H, Regli F (1996) Neurological and neuropsychological complications of bilateral contemporaneous pallidotomy in Parkinson’s disease (abstract). Neurology 46: A417

    Google Scholar 

  29. Golbe LI, Pae J (1988) Validity of a mailed epidemiological questionnaire and physical self-assessment in Parkinson’s disease. Mov Disord 3: 245–254

    Article  PubMed  CAS  Google Scholar 

  30. Green J, Vitek JL, Baron M, Bakey RAE, DeLong MR (1996) Neuropsychological sequelae of pallidotomy for treatment of Parkinson’s disease: one year pilot findings (abstract). Neurology 46: A200

    Google Scholar 

  31. Grafton ST, Waters C, Sutton J, Lew MF, Couldwell W (1995) Pallidotomy increases activity of motor association cortex in Parkinson’s disease: a positron emission tomographic study. Ann Neurol 37: 776–783

    Article  PubMed  CAS  Google Scholar 

  32. Hariz MI, DeSalles AAF (1996) The side-effects and complications of posteroventral pallidotomy (abstract). Acta Neurochir (Wien) 138: 643

    Google Scholar 

  33. Hariz MI, Bergenheim AT, Fodstad H (1993) Air-ventriculography provokes an anterior displacement of the third ventricle during functional stereotactic surgery. Acta Neurochir (Wien) 123: 147–152

    Article  CAS  Google Scholar 

  34. Hariz MI, Bergenheim AT (1990) A comparative study on ventriculographic and computed tomography-guided determinations of brain targets in functional stereotaxis. J Neurosurg 73: 565–571

    Article  PubMed  CAS  Google Scholar 

  35. Hariz MI, Bergenheim AT (1993) Clinical evaluation of CT-guided versus ventriculography-guided thalamotomy for movement disorders. Acta Neurochir (Wien) [Suppl] 58: 53–55

    CAS  Google Scholar 

  36. Hariz MI (1990) Correlation between clinical outcome and size and site of the lesion in CT-guided thalamotomy and pallidotomy. Stereotact Funct Neurosurg 54 and 55: 172–185

    Article  Google Scholar 

  37. Hariz MI (in press) Image-guided functional ablation of the brain. In: DeSalles AAF, Lufkin R (eds) Minimally invasive therapy of the brain. Thieme, Stuttgart

    Google Scholar 

  38. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression, and mortality. Neurology 17: 427–442

    Article  PubMed  CAS  Google Scholar 

  39. Hutchison WD, Lozano AM, Davis KD, Saint-Cyr JA, Lang AE, Dostrovsky JO (1994) Differential neuronal activity in segments of globus pallidus in Parkinson’s disease patients. NeuroReport 5: 1533–1537

    Article  PubMed  CAS  Google Scholar 

  40. Iacono RP, Lonser RR, Mandybur G, Morenski JD, Yamada S, Shima F (1994) Stereotactic pallidotomy results for Parkinson’s exceed those of fetal graft. Am Surg 60: 777–782

    PubMed  CAS  Google Scholar 

  41. Iacono RP, Lonser RR (1994) Reversal of Parkinson’s akinesia by pallidotomy (letter). Lancet 343: 418–419

    Article  PubMed  CAS  Google Scholar 

  42. Iacono RP, Lonser RR, Mandybur G, Yamada S (1995) Stimulation of the globus pallidus in Parkinson’s disease. Br J Neurosurg 9: 505–510

    Article  PubMed  CAS  Google Scholar 

  43. Iacono RP, Lonser RR, Yamada Sh (1994) Contemporaneous bilateral postero-ventral pallidotomy for early onset “juvenile type“ Parkinson’s disease. Case report. Acta Neurochir (Wien) 131: 247–252

    Article  CAS  Google Scholar 

  44. Iacono RP, Lonser RR, Maeda G, Kuniyoshi S, Warner D, Mandybur G, Yamada Sh (1995) Chronic anterior pallidal stimulation for Parkinson’s disease. Acta Neurochir (Wien) 137: 106–112

    Article  CAS  Google Scholar 

  45. Iacono RP, Shima F, Lonser RR, Kuniyoshi S, Maeda G, Yamada S (1995) The results, indications and physiology of posteroventral pallidotomy for patients with Parkinson’s disease. Neurosurgery 36: 1118–1127

    Article  PubMed  CAS  Google Scholar 

  46. Johansson F, Malm J, Nordh E, Hariz M (in press) The usefulness of pallidotomy in advanced Parkinson’s disease. J Neurosurg Neurol Psychiatry

    Google Scholar 

  47. Jones MW, Tasker RR (1990) The relationship of documented destruction of specific cell types to complications and effectiveness in thalamotomy for tremor in Parkinson’s disease. Stereotact Funct Neurosurg 54 and 55: 207–211

    Article  Google Scholar 

  48. Kelly PJ, Gillingham FJ (1980) The long-term results of stereotaxic surgery and L-dopa therapy in patients with Parkinson’s disease. A 10-year follow-up study. J Neurosurg 53: 332–337

    Article  PubMed  CAS  Google Scholar 

  49. Kelly PJ (1988) Contempory Stereotactic Ventralis Lateral Thalamotomy in the Treatment of Parkinsonian Tremor and Other Movement Disorders. In: Heilbrun MP (ed) Stereotactic neurosurgery, vol 2. Willliams and Wilkins, Baltimore, pp 133–147

    Google Scholar 

  50. Kelly PJ (1995) Pallidotomy in Parkinson’s disease (editorial comment). Neurosurgery 36: 1154–1157

    Article  PubMed  CAS  Google Scholar 

  51. Kishore A, Turnbull I, de la Fuente-Fernandez R, Schulzer M, Calne DB, Snow BJ (1996) Ventral pallidotomy improves motor signs and dyskinesias in Parkinson’s disease (abstract). Mov Disord 11[Suppl 1]: 240

    Google Scholar 

  52. Kondziolka D, Bonaroti EA, Lunsford LD (1996) Pallidotomy for Parkinson’s disease. Contemp Neurosurg 18(6): 1–7

    Google Scholar 

  53. Kondziolka D, Dempsey PK, Lunsford LD, Kestle JRW, Dolan EJ, Kanal E, Tasker RR (1992) A comparison between magnetic resonance imaging and computed tomography for stereotactic coordinate determination. Neurosurgery 30: 402–407

    Article  PubMed  CAS  Google Scholar 

  54. Laitinen L, Johansson GG, Sipponen P (1966) Impedance and phase angle as a locating method in human stereotaxic surgery. J Neurosurg 25: 628–633

    Article  PubMed  CAS  Google Scholar 

  55. Laitinen L, Vilkki J (1973) Measurement of parkinsonian hypokinesia with Purdue pegboard and motor reaction time tests. In: Siegfried J (ed) Parkinson’s disease, vol 1. Hans Huber, Berlin, pp 185–192

    Google Scholar 

  56. Laitinen LV, Bergenheim AT, Hariz MI (1992) Leksell’s posteroventral pallidotomy in the treatment of Parkinson’s disease. J Neurosurg 76: 53–61

    Article  PubMed  CAS  Google Scholar 

  57. Laitinen LV, Bergenhcim AT, Hariz MI (1992) Ventropos-terolateral pallidotomy can abolish all parkinsonian symptoms. Stereotact Funct Neurosurg 58: 14–21

    Article  PubMed  CAS  Google Scholar 

  58. Laitinen LV, Hariz MI (1996) Movement disorders. In: JR Youmans (ed) Neurological surgery, 4th ed. Saunders, Philadelphia, pp 3575–3609

    Google Scholar 

  59. Laitinen LV (1985) Brain targets in surgery for Parkinson’s disease. J Neurosurg 62: 349–351

    Article  PubMed  CAS  Google Scholar 

  60. Laitinen LV (1995) Pallidotomy for Parkinson’s disease. Neurosurgery Clin North Am 6: 105–112

    CAS  Google Scholar 

  61. Laitinen LV (1988) The Laitinen system. In: Lunsford LD (ed) Modern stereotactic neurosurgery. Nijhoff, Boston, pp 99–116

    Chapter  Google Scholar 

  62. Laitinen LV (1994) Ventroposterolateral pallidotomy. Stereotact Funct Neurosurg 62: 41–52

    Article  PubMed  CAS  Google Scholar 

  63. Lang AE, Lozano A, Duff J, Miyasaki J, Galvez-Jiminez N, Hutchison W, Tasker R, Dostrovsky J (1995) Posteroventral medial pallidotomy in Parkinson’s disease (abstract). Mov Disord 10: 691

    Google Scholar 

  64. Lang, AET, Fahn S (1989) Assessment of Parkinson’s disease. In: Munsat TL (ed) Quantification of neurologic deficit. Butterworths, Boston, pp 285–301

    Google Scholar 

  65. Linazasoro G, Guridi J, Gorospe A, Ramos E, Mozo A, Obeso JA (1996) Posteroventral pallidotomy in Parkinson’s disease. Clinical results in 27 patients (abstract). Mov Disord 11[Suppl 1]: 240

    Google Scholar 

  66. Louis ED, Lynch T, Marder K, Fahn S (1996) Reliability of patient completion of the historical section of the unified Parkinson’s disease rating scale. Mov Disord 11: 185–192

    Article  PubMed  CAS  Google Scholar 

  67. Lozano AM, Hutchison WD, Dostrovsky JO (1995) Microelectrode monitoring of cortical and subcortical structures during stereotactic surgery. Acta Neurochir (Wien) [Suppl] 64: 30–34

    Article  CAS  Google Scholar 

  68. Lozano A, Hutchison W, Kiss Z, Tasker R, Davis K, Dostrovsky J (1996) Methods for microelectrode-guided posteroventral pallidotomy. J Neurosury 84: 194–202

    Article  CAS  Google Scholar 

  69. Lozano AM, Lang AE, Galvez-Jimenez N, Miyasaki J, Duff J, Hutchison WD, Dostrovsky JO (1995) Effect of GPi pallidotomy on motor function in Parkinson’s disease. Lancet 346: 1383–1387

    Article  PubMed  CAS  Google Scholar 

  70. Marsden CD, Obeso JA (1994) The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson’s disease. Review article. Brain 117: 877–897

    Google Scholar 

  71. Meyer CHA (1996) Pallidotomy for Parkinson’s disease promptly improves a wide range of voluntary activities — especially gait and trunk movements. (abstract) Acta Neurochir (Wien) 138: 635

    Google Scholar 

  72. Quinn N (1994) Reversal of Parkinson’s akinesia by pallidotomy (letter). Lancet 343: 1095–1096

    Article  PubMed  CAS  Google Scholar 

  73. Rand RW, Jacques DB, Mclbye RW, Copcull BG, Fisher MR, Levenick MN (1993) Gamma knife thalamotomy and pallidotomy in patients with movement disorders: preliminary results. Stereotact Funct Neurosurg 61: 65–92

    Article  PubMed  Google Scholar 

  74. Schaltenbrand G, Wahren W (1977) Atlas for stereotaxy of the human brain, 2nd ed. Thieme, Stuttgart

    Google Scholar 

  75. Schwab RS, England AC Jr (1969) Projection technique for evaluating surgery in Parkinson’s disease. In: Gillingham FJ, Donaldson JM (eds) Third symposium on Parkinson’s disease. Livingstone, Edingburgh, pp 152–157

    Google Scholar 

  76. Siegfried J, Lippitz B (1994) Bilateral chronic electrostimulation of ventroposterolateral pallidum: a new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery 35: 1126–1130

    Article  PubMed  CAS  Google Scholar 

  77. Siegfried J, Lippitz B (1994) Chronic electrical stimulation of the VL-VPL complex and of the pallidum in the treatment of movement disorders: personal experience since 1982. Stereotact Funct Neurosurg 62: 71–75

    Article  PubMed  CAS  Google Scholar 

  78. Spiegelmann R, Chasin S (1996) Posteroventral pallidotomy: experience with 100 cases (abstract). Acta Neurochir (Wien) 138: 644

    Article  Google Scholar 

  79. Sterio D, Beric A, Dogali M, Fazzini E, Alfaro G, Devinsky O (1994) Neurophysiological properties of pallidal neurons in Parkinson’s disease. Ann Neurol 35: 586–591

    Article  PubMed  CAS  Google Scholar 

  80. Sterio D, Markovic Lj, Kelly P, Beric A (1996) Activity of globus pallidus neurons in Parkinson’s disease (abstract). Mov Disord 11[Suppl 1]: 78

    Google Scholar 

  81. Sutton JP, Coulwell W, Lew MF, Mallory L, Grafton S, DeGiorgio C, Welsh M, Apuzzo MLJ, Ahmadi J, Waters CH (1995) Ventroposterior medial pallidotomy in patients with advanced Parkinson’s disease. Neurosurgery 36: 1112–1117

    Article  PubMed  CAS  Google Scholar 

  82. Svennilson E, Torvik A, Lowe R, Leksell L (1960) Treatment of Parkinsonism by stereotactic thermolesions in the pallidal region. Acta Psychiatr Neurol Scand 35: 358–377

    Article  CAS  Google Scholar 

  83. Tasker RR, Yamashiro K, Lenz F (1988) Thalamotomy for Parkinson’s Disease: Microelectrode Technique. In: Lunsford LD (ed) Modern stereotactic neurosurgery. Nijhoff, Boston, pp 297–314

    Chapter  Google Scholar 

  84. Tourtellotte WW, Syndulko K (1989) Quantifying the neurologic examination: principles, constraints, and opportunities. In: Munsat TL (ed) Quantification of neurologic deficit. Butterworths, Boston, pp 7–16

    Google Scholar 

  85. Tsubokawa T, Moriyasu N (1975) Lateral pallidotomy for relief of ballistic movement — its basic evidences and clinical application. Confin Neurol 37: 10–15

    Article  PubMed  CAS  Google Scholar 

  86. Van Manen J (1969) Postural instability after ventrolateral thalamic lesions. In: Gillingham FJ, Donaldson IML (eds) Third symposium on Parkinson’s disease. Livingstone, London, pp 237–241

    Google Scholar 

  87. Vitek JL, Hashimoto T, Baron M, Kaneoke Y, Turner R, Bakay R, DeLong MR (1994) Pallidotomy in Parkinson’s disease: correlation of lesion location to clinical outcome. (abstract). Mov Disord 9: 477–478

    Google Scholar 

  88. World Health Organization (1980) International classification on impairments, disability, and handicaps. World Health Organization, Geneva

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

C. B. Ostertag D. G. T. Thomas A. Bosch B. Linderoth G. Broggi

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Wien

About this paper

Cite this paper

Hariz, M.I. (1997). Controversies in Pallidal Surgery. In: Ostertag, C.B., Thomas, D.G.T., Bosch, A., Linderoth, B., Broggi, G. (eds) Advances in Stereotactic and Functional Neurosurgery 12. Acta Neurochirurgica Supplements, vol 68. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6513-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6513-3_1

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7341-1

  • Online ISBN: 978-3-7091-6513-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics