Summary
In order to study the putative monoamine oxidase (MAO) inhibitory side effect of neuroleptics and simultaneous changes in platelet serotonin content both MAO-B activity and serotonin (5-HT) content in platelets of 30 healthy volunteers and 50 schizophrenic patients treated with neuroleptics were investigated. Our results have shown significantly lower MAO-B activity (15.26 ± 6.81 S.D. vs. 8.63 ± 3.82mmol/hour/109 platelets) and higher platelet 5-HT content (906.19 ± 285.33 vs. 1,727.85 ± 947.40ng/109 platelets) in the schizophrenic group. Platelet MAO-B activity was considerably lower in paranoid and residual schizophrenics compared with other patients, however, no difference was found in platelet 5-HT content between different subtypes of schizophrenia. Various neuroleptic treatments did not produce different effects either on platelet serotonin content or platelet MAO-B activity.
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© 1998 Springer-Verlag Wien
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Mészáros, Z., Borcsiczky, D., Máté, M., Tarcali, J., Tekes, K., Magyar, K. (1998). MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients. In: Finberg, J.P.M., Youdim, M.B.H., Riederer, P., Tipton, K.F. (eds) MAO — The Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement, vol 52. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6499-0_9
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DOI: https://doi.org/10.1007/978-3-7091-6499-0_9
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83037-6
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