Long term administration of (—)-deprenyl increases mortality in male Wistar rats

  • I. M. Gallagher
  • A. Clow
  • V. Glover
Part of the Journal of Neural Transmission. Supplement book series (NEURAL SUPPL, volume 52)


Long term administration of the monoamine oxidase inhibitor (—)-deprenyl (0.5mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat, whereas the dopamine agonist pergolide (0.4mg/Kg) and the antioxidant diethyldithiocarbamate (400mg/Kg) had no significant effect on mortality. The increased mortality was not related to dietary intake or body weight of the rats. This is of interest in the light of recent evidence that (—)-deprenyl increases mortality in humans.


Life Span Monoamine Oxidase Inhibitor Reduce Food Intake Term Administration Daily Food Intake 
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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • I. M. Gallagher
    • 1
    • 1
  • A. Clow
    • 2
  • V. Glover
    • 1
  1. 1.Department of PaediatricsQueen Charlotte’s sand Chelsea HospitalLondonUK
  2. 2.School of Biological & Health SciencesUniversity of WestminsterLondonUK

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