Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology
The present report reviews recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.
KeywordsMonoamine Oxidase Locus Coeruleus Neurobiol Aging Hybridization Histochemistry Human Substantia Nigra
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- Anderson JK, Frim DM, Isacson O, Breakfield XO (1994) Catecholaminergic cell atrophy in a transgenic mouse aberrantly overexpressing MAO-B in neurons. Neurodegen 3: 97–109Google Scholar
- Cohen G (1986) Monoamine oxidase, hydrogen peroxide and Parkinson’s disease. Adv Neurol 45: 119–125Google Scholar
- Da Prada M, Pieri L, Cesura AM, Kettler R (1994a) The pharmacology of moclobemide. Revs Contemp Pharmacol 5: 1–18Google Scholar
- Da Prada M, Zurcher G, Kettler R, Dingemanse K, Jorga K, Dubuis R (1994b) Remodelling the kinetics and dynamics of levodopa therapy in Parkinson’s disease by inhibiting MAO-B with lazabemide and COMT with tolcapone. In: Poewe W, Lees AJ (eds) Levodopa — the first 25 years. Proceedings of the Symposium “20 Years of MadoparR, New Avenues”, Berlin, October 1993. Editiones Roche, Basel, pp 99–117Google Scholar
- Moll G, Moll R, Riederer P, Gsell W, Heinsen H, Denney RM (1990) Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of monoamine oxidase A and monoamine oxidase B, a pilot study. J Neural Transm [Suppl] 32: 67–77Google Scholar
- Ordway GA, Klimek V, Richards JG, Overholser JC, Meltzer HY, Dilley G, Stockmeier CA (1996) [3H]Ro 41-1049 binding to monoamine oxidase-A in the locus coeruleus is not altered in major depression. Soc Neurosci Abstr 368.2Google Scholar
- Oreland L, Jossan SS, Hartvig P, Aquilonius SM, Langstrom B (1990) Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-deprenyl. J Neural Transm [Suppl] 32: 55–59Google Scholar
- Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih JC, Malherbe P, Da Prada M, Richards JG (1996) Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience 70: 755–774PubMedCrossRefGoogle Scholar
- Saura J, Andres N, Andrade C, Ojuel J, Eriksson K, Mahy N (1997) Biphasic and region-specific MAO-B response to aging in control human brain. Neurobiol Aging (in press)Google Scholar
- Strolin-Benedetti M, Dostert P (1992) Monoamine oxidase: from physiology and pathophysiology to the design and clinical applications of reversible inhibitors. Adv Drug Res 23: 65–125Google Scholar
- Waldmeier PC (1987) Amine oxidases and their endogenous substrates (with special reference to monoamine oxidase and the brain). J Neurotransm [Suppl] 23: 55–72Google Scholar
- Zetsche T, Chan-Palay V (1992) MAO-A and MAO-B immunoreactivity in the hippocampus, temporal cortex and cerebellum of normal controls and of patients with senile dementia of the Alzheimer type. Dementia 3: 270–281Google Scholar