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The neuroprotective and neuronal rescue effects of (—)-deprenyl

  • K. Magyar
  • B. Szende
  • J. Lengyel
  • J. Tarczali
  • I. Szatmáry
Part of the Journal of Neural Transmission. Supplement book series (NEURAL SUPPL, volume 52)

Summary

The pharmacological effects of (—)-deprenyl is multi-fold in its nature (dopamine sparing activity, neuroprotective and neuronal rescue effects), which cannot be explained solely by the irreversible MAO-B inhibitory action of the substance. Deprenyl slightly inhibits the re-uptake of noradrenaline and dopamine, but methylamphetamine, the metabolite of the inhibitor, by one order of magnitude is more potent in this respect, than the parent compound. Neither the metabolite nor (—)-deprenyl acts on the uptake of serotonin. The inhibitor has an intensive first pass metabolism after oral treatment. The in vivo pharmacokinetic studies with (—)-deprenyl, using the double labelled radioisotope technique (1.5mg/kg; orally) in rats revealed that the molar concentration of methylamphetamine can reach the level suitable to induce a significant inhibition of amine uptake. Deprenyl, but especially methylamphetamine pre-treatment can prevent the noradrenaline release induced by the noradrenergic neurotoxin DSP-4. The uptake inhibitory effect of (—)-deprenyl and the metabolites is reversible. After repeated administration of (—)-deprenyl (1.5mg/kg daily, for 8 days) sustained concentration of its metabolites was detected, compared to that of the acute studies. This can at least partly explain why (—)deprenyl should be administered daily to evoke therapeutic effects in Parkinson’s disease. Administration of (-)deprenyl in a low dose, following the toxic insult, can rescue the damaged neurones. The neuronal rescue effect of the drug was studied on M-1 human melanoma cells in tissue culture. The inhibitor reduced the apoptosis of serum-deprived M-1 cells, but the ( + )-isomer failed to exert this effect. The (±)-desmethyl-deprenyl almost lacks the property to inhibit apoptosis. For neuroprotection and neuronal rescue an optimal dose of (—)-deprenyl should be administered, because to reach a well balanced concentration of the metabolites in tissues is critical.

Keywords

Human Melanoma Cell Corpus Striatum Neuronal Rescue Subacute Treatment Subacute Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • K. Magyar
    • 1
    • 5
  • B. Szende
    • 2
  • J. Lengyel
    • 3
  • J. Tarczali
    • 1
  • I. Szatmáry
    • 4
  1. 1.Departments of PharmacodynamicsSemmelweis University of MedicineBudapestHungary
  2. 2.Departments of Pathology and Experimental Cancer ResearchSemmelweis University of MedicineBudapestHungary
  3. 3.Departments of Central Isotope LaboratorySemmelweis University of MedicineBudapestHungary
  4. 4.Chinoin Pharmaceutical WorksBudapestHungary
  5. 5.Department of PharmacodynamicsSemmelweis University of MedicineBudapestHungary

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