Concepts on the prognostic significance of white matter changes

  • P. Kapeller
  • R. Schmidt
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 53)


Magnetic resonance imaging white matter changes are a common observation in the elderly. The prognostic significance of such abnormalities is incompletely understood. Correlative studies which are reviewed here, suggested a predictive potential of white matter abnormalities for ischemic stroke, intracerebral hemorrhage, cognitive decline or even dementia. According to current review of literature the most compelling evidence for such a relationship exists for intellectual dysfunction. So far, there exist only preliminary data on the rate of WMH progression, but these demonstrate, at least some increase in number or extent within relatively short observational periods.


White Matter Intracerebral Hemorrhage White Matter Lesion White Matter Hyperintensities White Matter Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • P. Kapeller
    • 1
  • R. Schmidt
    • 1
  1. 1.Department of NeurologyKarl Franzens University GrazGrazAustria

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