Can Cerebrolysin® influence chronic deterioration of spatial learning and memory?

  • V. Valoušková
  • L. Francis-Turner
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 53)


Our previous studies showed that the nootropic drug Cerebrolysin®, applied immediately after the traumatic or excitotoxic brain lesion influenced spatial learning and memory. Long-lasting ameliorative effect of Cerebrolysin was found after its 4-week-administration, while two-week-treatment had only temporal effect.

With the aim to verify the capability of Cerebrolysin® to restore chronically deteriorated learning and memory, The drug was applied 4 months after lesioning the rat’s CNS. The present study shows that Cerebrolysin restored learning capability of the lesioned rats. Although their spatial memory was improved in comparison to lesion untreated controls, it did not reach the level of intact controls. The effect was more pronounced after the application of 1.25 ml/kg b. w. of Cerebrolysin® than after the application of 2.5 ml/kg b. w.


Spatial Memory Spatial Learning Intact Control Carotid Artery Occlusion Nootropic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • V. Valoušková
    • 1
  • L. Francis-Turner
    • 1
  1. 1.Academy of Sciences of Czech RepublicInstitute of PhysiologyPrague 4Czech Republic

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