Summary
Levels of catalase (CAT) and Superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which recieved Cerebrolysin® (CRB) or saline solution (SAL) for a week. We found that Cerebrolysin® induces a decrease on the CAT and SOD levels. Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SHPL-SAL group. The lowest CAT levels were detected in the INT-CER group (16.7). The SOD levels obtained in SHPL-CER group (9.84) were also smaller than those obtained in the SHPL-SAL group (14.9) which showed the highest levels of SOD, while the INT animals showed the lowest levels (7.6). In addition, the SHPL animals mortality was of 18% for the CER group against 43% for SAL group. We suggest the Cerebrolysin® effect on CAT and SOD activity is related with a beneficial antioxidative role which may have potential application on brain injury.
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References
Aebi H (1984) Catalase in vitro. Methods Enzymol 105: 121–126
Akai F, Hiruma S, Sato T, Iwamoto N, Ioku M, Hashimoto S (1992) Neurotrophic factor — like effect of FPF1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. Histol Histophaol 7: 213–221
Benzi G, Moretti (1995) Age and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 19: 77–101
Benzi G, Moretti A (1995) Are reactive oxygen species involve in Alzheimer disease? Neurobiol Aging 16: 661–674
Ceballos-Picot I, Trivier JM, Nicole A, Sinet PM, Thevenin M (1992) Age correlated modifications of Copper-Zinc Superoxide dismutase and glutathione-related enzyme activities in human erythrocytes. Clin Chem 38: 66–70
Choi BH (1995) Oxidative stress and Alzheimer’s disease. Neurobiol Aging 16: 675–678
Colton C, Wilt S, Gilber D, Chernyshev O, Snell, Dubois-Dalq M (1996) Species differences in the generation of reactive oxigen species by microglia. Mol Chem Neuropathol 28: 15–20
De Haan JB, Cristiano F, Iannello RC, Kola I (1995) Cu/Zn Superoxide dismutase and gluthathione peroxidase during aging. Biochem Mol Biol Int 35: 1281–1297
Durusoy M, Diril N, Bozcuk N (1995) Age-related activity of catalase in different genotypes of drosophila melanogaster. Exp Gerontol 30: 77–86
Ebewe pharmaceuticals (1992) Cerebrolysin for the modern effective theraphy of disturbed cerebral functions. Ebewe Arzneimittel Ges.m.b.H., A-4866 Unterach, Austria, p 84
Marklund J (1992) Involvement of the Superoxide anion radical in autoxidation of pirogallol as a convenient assay for Superoxide dismutase. Eur J Biochem 47: 469–474
Matson MP, Furukawa K (1996) Progarmed cell life: anti-apoptotic signaling and therapeutic for neurodegenerative disorders. Restorat Neurol Neurosci 9: 191–205
Mo JQ, Horn DG, Andersen JK (1995) Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain. Mech Ageing Dev 81: 73–82
Moreno S, Mugnaini E, Cerú P (1995) Inmunohistochemical localization of catalase in the central nervous system of the rat. J Histochem Cytochem 43: 1253–1267
Olanow CW (1992) An introduction to the free radical hypothesis in Parkinson’s disease. Ann Neurol 32: 2–9
Racagni G, Brunello N, Langer SZ (1994) Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction. In: Int Acad Biomed Drug Res, vol 7. Karger, Basel, p 327
Singh A (1989) Chemical and biochemical aspects of activated oxygen: singlet oxygen, Superoxide anion, and related species. In: Handbook of free radicals and antioxidants in biomedicine, vol 1. Press, Iloride, pp 177–182
Sugita Y, Kondo T, Kanazawa A, Itou T, Mixuno Y (1993) Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil: detection of hydroxyl radical with salisylic acid. No To Shinkei 45: 325–331
Zhang P, Damier P, Hirsch EC, Agyd Y, Ceballos-Picot I, Sinet PM, Nicole A, Laurent M, Javoy-Agyd F (1993) Preferential expression of Superoxide dismutase messenger RNA in melanized neurons in human mesencephalom. Neuroscience 55: 167–175
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© 1998 Springer-Verlag Wien
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González, M.E., Francis, L., Castellano, O. (1998). Antioxidant systemic effect of short-term Cerebrolysin® administration. In: Jellinger, K., Fazekas, F., Windisch, M. (eds) Ageing and Dementia. Journal of Neural Transmission. Supplementa, vol 53. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6467-9_29
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DOI: https://doi.org/10.1007/978-3-7091-6467-9_29
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83114-4
Online ISBN: 978-3-7091-6467-9
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