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Antioxidant systemic effect of short-term Cerebrolysin® administration

  • M. E. González
  • L. Francis
  • O. Castellano
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 53)

Summary

Levels of catalase (CAT) and Superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which recieved Cerebrolysin® (CRB) or saline solution (SAL) for a week. We found that Cerebrolysin® induces a decrease on the CAT and SOD levels. Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SHPL-SAL group. The lowest CAT levels were detected in the INT-CER group (16.7). The SOD levels obtained in SHPL-CER group (9.84) were also smaller than those obtained in the SHPL-SAL group (14.9) which showed the highest levels of SOD, while the INT animals showed the lowest levels (7.6). In addition, the SHPL animals mortality was of 18% for the CER group against 43% for SAL group. We suggest the Cerebrolysin® effect on CAT and SOD activity is related with a beneficial antioxidative role which may have potential application on brain injury.

Keywords

Oxidative Imbalance Septal Cholinergic Neuron Hippocampal Pathway Reactive Oxigen Species Melanize Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • M. E. González
    • 1
    • 4
  • L. Francis
    • 2
  • O. Castellano
    • 3
  1. 1.NeurobiochemistryInternational Center for Neurological RestorationPlaya Ciudad de la HabanaCuba
  2. 2.BiomodelsInternational Center for Neurological RestorationPlaya Ciudad de la HabanaCuba
  3. 3.Neuromorphology LaboratoryInternational Center for Neurological RestorationPlaya Ciudad de la HabanaCuba
  4. 4.Neurobiochemistry LaboratoryInternational center for Neurological RestorationCubanacán, Playa Ciudad de la HabanaCuba

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