The influence of Cerebrolysin® and E021 on spatial navigation of 24-month-old rats

  • A. Gschanes
  • M. Windisch
Part of the Journal of Neural Transmission. Supplementa book series (NEURAL SUPPL, volume 53)


In the present study the behavioural effects of Cerebrolysin® (Cere), a peptidergic nootropic drug, and E021, the concentrated peptide fraction of Cere, were investigated in 24-month-old rats. Rats passing a pretest to exclude motor-and eye-deficits were treated with either drugs or saline as control (2.5 ml/kg, intraperitoneally i.p.) for 19 days. Animals were tested in a standard Morris water maze on day 16 after pretest for 4 consecutive days (test days 1–4), eight trials per day. No significant differences of escape latency between males and females were found, therefore, results were pooled.

Both Cere and E021 treated rats showed significant lower escape latencies than saline treated controls on all four test days (p < 0.01). More pronounced effects of both drugs were found for female rats.

Female rats showed no significant differences in motor activity whereas drug treated males swam quicker on test day 1 (Cere p < 0.01; E021 P < 0.05) and day 2 (Cere p < 0.01).

In the present experiments it was demonstrated that i.p. administration of both Cere and E021 improves the spatial learning and memory of 24-monthold male and female rats.


Morris Water Maze Passive Avoidance Swimming Speed Escape Latency Spatial Navigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • A. Gschanes
    • 1
  • M. Windisch
    • 1
  1. 1.Institute of Experimental PharmacologyResearch Initiative EbeweGrazAustria

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