Neurotrophic factors attenuate neuronal nitric oxide synthase upregulation, microvascular permeability disturbances, edema formation and cell injury in the spinal cord following trauma: an experimental study using topical application of BDNF and IGF-1 in the rat

  • H. S. Sharma
  • F. Nyberg
  • T. Gordh
  • P. Alm
  • J. Westman


Injury to the spinal cord is one of the important causes of disability in human population suffering from trauma and no success to treat this medical catastrophe has yet been achieved (Faden and Salzman, 1992; Faden, 1993). Paralysis, paraplegia and life-time rehabilitation are the main problems of spinal cord injury victims throughout the world (Schwab and Bartholdi, 1996). Most of the incomplete spinal cord damage are at least partially reversible, if treated immediately following the primary insult. On the other hand, a delay in treatment schedule beyond 8 h following the primary insult, no significant neuroprotection is achieved irrespective of therapy (for review see Faden, 1993; Schwab and Bartholdi, 1996; Winkler et al., 1998, for details see Chapters 14, 16, 17, 19 in this volume). Thus efforts should be made to treat trauma patients as soon as possible following initial traumatic events.


Spinal Cord Spinal Cord Injury Dorsal Root Ganglion Neurotrophic Factor Lesion Spinal Cord 
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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • H. S. Sharma
    • 1
  • F. Nyberg
    • 2
  • T. Gordh
    • 3
  • P. Alm
    • 4
  • J. Westman
    • 1
  1. 1.Department of Medical Cell BiologyLaboratory of NeuroanatomySweden
  2. 2.Department of Pharmaceutical BiosciencesBiomedical CentreSweden
  3. 3.Department of AnaesthesiologyUniversity Hospital. Uppsala UniversityUppsalaSweden
  4. 4.Department of PathologyUniversity Hospital, Lund UniversityLundSweden

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