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Neurotrophic factors attenuate neuronal nitric oxide synthase upregulation, microvascular permeability disturbances, edema formation and cell injury in the spinal cord following trauma: an experimental study using topical application of BDNF and IGF-1 in the rat

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Spinal Cord Monitoring

Abstract

Injury to the spinal cord is one of the important causes of disability in human population suffering from trauma and no success to treat this medical catastrophe has yet been achieved (Faden and Salzman, 1992; Faden, 1993). Paralysis, paraplegia and life-time rehabilitation are the main problems of spinal cord injury victims throughout the world (Schwab and Bartholdi, 1996). Most of the incomplete spinal cord damage are at least partially reversible, if treated immediately following the primary insult. On the other hand, a delay in treatment schedule beyond 8 h following the primary insult, no significant neuroprotection is achieved irrespective of therapy (for review see Faden, 1993; Schwab and Bartholdi, 1996; Winkler et al., 1998, for details see Chapters 14, 16, 17, 19 in this volume). Thus efforts should be made to treat trauma patients as soon as possible following initial traumatic events.

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Authors and Affiliations

  1. Department of Medical Cell Biology, Laboratory of Neuroanatomy, Sweden

    H. S. Sharma & J. Westman

  2. Department of Pharmaceutical Biosciences, Biomedical Centre, Sweden

    F. Nyberg

  3. Department of Anaesthesiology, University Hospital. Uppsala University, Uppsala, Sweden

    T. Gordh

  4. Department of Pathology, University Hospital, Lund University, Lund, Sweden

    P. Alm

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  5. J. Westman
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Editors and Affiliations

  1. Department of Clinical Neurophysiology, University Hospital, Uppsala University, Uppsala, Sweden

    Erik Stålberg M.D.

  2. Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden

    Hari Shanker Sharma Ph.D.

  3. Laboratory of Neuropathology, Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

    Yngve Olsson M.D.

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Sharma, H.S., Nyberg, F., Gordh, T., Alm, P., Westman, J. (1998). Neurotrophic factors attenuate neuronal nitric oxide synthase upregulation, microvascular permeability disturbances, edema formation and cell injury in the spinal cord following trauma: an experimental study using topical application of BDNF and IGF-1 in the rat. In: Stålberg, E., Sharma, H.S., Olsson, Y. (eds) Spinal Cord Monitoring. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6464-8_8

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