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The role of glycine in pain and spasticity

  • R. K. SimpsonJr.
  • C. S. Robertson
  • J. Clay Goodman

Abstract

Neuropathic pain is an intense pain perceived without an obvious noxious stimulus. Spasticity is heightened stretch reflexes and excessive muscle tonus. Both are a common and severely debilitating sequela to injury of the nervous system and both conditions frequently occur together simultaneously. In order to support this glycine-based theory we tested the primary hypothesis with the assumption that a relationship exists between segmentai glycine levels and neuropathic pain and spasticity. These tests included: 1) the detection of segmentai glycine release after motor and sensory pathway stimulation in normal injured animals, 2) the reduction of pain and spasticity following administration of glycine, and its receptor agonists, and 3) the production of pain and spasticity following administration of glycine receptor antagonists. Once fulfilled, results from these experiments would support the goal directed toward enhancing glycine receptor mechanisms as treatment for neuropathic pain and spasticity. Two animal models were employed to test the hypothesis, 1) a classic model of neuropathic pain in the rat created by sciatic nerve constriction, and 2) an established model of spasticity in the rabbit created by spinal cord ischemia.

Keywords

Spinal Cord Neuropathic Pain Glycine Receptor Spinal Cord Ischemia Excitatory Amino Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • R. K. SimpsonJr.
    • 1
  • C. S. Robertson
    • 1
  • J. Clay Goodman
    • 2
  1. 1.Departments of NeurosurgeryBaylor College of MedicineHoustonUSA
  2. 2.Departments of PathologyBaylor College of MedicineHoustonUSA

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