Substance P transmitter or regulator in spinal sensory mechanisms?

  • J. L. Henry


Evidence is reviewed which suggests multifunctional roles of substance P in spinal nociceptive pathways. There remains little challenge today to the notion that substance P is involved in excitatory regulation of nociception in the region of the first sensory synapse at spinal and brain stem levels. Criteria seem to be satisfied for substance P to qualify as a neurotrans-mitter. Actions of substance P on dorsal horn nociceptive neurones do seem to include relatively fast changes which can be consistent with those induced by a neurotransmitter (Otsuka and Yoshioka, 1993; Henry, 1993).


Spinal Dorsal Nociceptive Response Dorsal Rhizotomy Wide Dynamic Range Neurone Cutaneous Receptive Field 
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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • J. L. Henry
    • 1
  1. 1.Department of Physiology and PsychiatryMcGill UniversityMontrealCanada

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