A combination of microdialysis, electrophysiology and histology for exploring secondary damage upon spinal cord Injury


Injury to the spinal cord is a major health care issue, causing lifelong disability to the victims. The damage worsens for hours after the initial trauma by secondary destructive processes that include release of agents that kill neurons, post injury ischemia, edema, inflammation, and oxidative damage. Agents suspected of causing secondary damage include excitatory neurotransmitters, free fatty acids, neuropeptides and free radicals. Oxidative damage to proteins, DNA and membrane lipids could be the final common pathway by which secondary injury substances cause neuronal degeneration. Reduction of secondary damage is the chief hope in the near future for reducing long term disability from spinal cord injury. A better understanding of the mechanisms behind secondary damage that accompany central nervous system trauma will pave the way to therapies that reduce damage following spinal cord injury.


Spinal Cord Nitric Oxide Spinal Cord Injury Membrane Lipid Peroxidation Secondary Damage 
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© Springer-Verlag Wien 1998

Authors and Affiliations

  • D. Liu
    • 1
  1. 1.Departments of Neurology and Human Biological Chemistry and GeneticsUniversity of Texas Medical BranchGalvestonUSA

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