Spinal cord blood flow and metabolism in transient spinal ischemia
Spinal cord ischemia and the resulting irreversible loss of neurological function (i.e. the development of spastic or flaccid paraplegia) represent serious complications associated with transient aortic cross-clamp (as for rep air of aortic aneurysm). While the precise mechanism leading to the irreversible spinal neuronal degeneration after spinal ischemia is not well understood, current experimental studies suggest that the progressive evolution of spinal injury after aortic cross clamp may be considered in at least two categories: i) spinal cord blood flow changes, and, ii) metabolic changes resulting from critical reduction of substrate (glucose/oxygen) delivery and corresponding release of active factors (excitatory amino acids, prostaglandins, oxygen free radicals etc.) into the spinal extracellular space.
KeywordsSpinal Cord Aortic Occlusion High Energy Phosphate Anterior Spinal Artery Spinal Cord Blood Flow
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