Learning from our foes: a novel vaccine concept for influenza virus

  • P. Palese
  • T. Muster
  • H. Zheng
  • R. O’Neill
  • A. Garcia-Sastre
Part of the Archives of Virology. Supplementa book series (ARCHIVES SUPPL, volume 15)


Concerted efforts to study the molecular biology of influenza viruses and the ability to genetically engineer them have dramatically advanced our understanding of the functions of influenza viral genes and gene products. The only nonstructural protein (NS1 ) coded for by the influenza virus was shown to possess interferon antagonist activity and thus to play an important role in countering the interferon (antiviral) response of the host following infection. Influenza A and B virus mutants with “weak” anti-interferon activity are highly attenuated because the host is able to mount an effective interferon response. It is suggested that these NS1-modified attenuated influenza viruses can induce a protective immune response and that they are ideal live virus vaccine candidates against influenza.


Influenza Virus Vaccine Strain Wild Type Virus Interferon Response Influenza Virus Vaccine 
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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • P. Palese
    • 1
  • T. Muster
    • 2
  • H. Zheng
    • 1
  • R. O’Neill
    • 1
  • A. Garcia-Sastre
    • 1
  1. 1.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA
  2. 2.Department of DermatologyUniversity of Vienna Medical SchoolViennaAustria

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