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The post-Loeffler-Frosch era: contribution of German virologists

Chapter
Part of the Archives of Virology. Supplementa book series (ARCHIVES SUPPL, volume 15)

Summary

This presentation dealt with the contributions of German virologists in the rapid development of virology following the Loeffler-Frosch era. Thereby, only research was included which was undertaken within German institutions, even though guest scientists from other countries or international cooperative efforts have in some cases contributed to the work. Contributions to the field of veterinary virology were not considered here, since this topic was treated separately during this centennial symposium.

The overview includes contributions of the very early period when interest was focussed mainly on the determination of the physicochemical properties of the fast growing number of newly detected viruses, and of the pioneering period when fundamental discoveries of the nature of viruses were made. The concepts that derived from those studies made the development of modern virology possible. Some highlights of the present period were presented describing the findings of selected virus families. This part was followed by a description of the results which were relevant to problems of how viruses become pathogens, and the role of the immune response to virus infections. Finally, attention was drawn to the contributions of molecular studies which became important not only for the field of virology but also for life sciences in general.

Keywords

Influenza Virus Tobacco Mosaic Virus Epidermodysplasia Verruciformis Laryngeal Papilloma Herpesvirus Saimiri 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Löwenstein A (1919) Mün Med Wochenschr 66: 769Google Scholar
  2. 2.
    Schneweis KE (1962) Z Immunforsch 124: 24Google Scholar
  3. 3.
    Siegelt R, Shu H-L, Slenczka W, Peters D, Müller G (1967) Dtsch Med Wochenschr 51: 2341CrossRefGoogle Scholar
  4. 4.
    zur Hausen, Gissmann L (1979) Med Microbiol Immunol 167: 137PubMedCrossRefGoogle Scholar
  5. 5.
    Zwick W, Seifried O, Witte J (1926) Z Inf Krankh Haustiere 30: 42Google Scholar
  6. 6.
    Rott, R, Herzog S, Bechter K, Frese K (1991) Arch Virol 118: 295CrossRefGoogle Scholar
  7. 7.
    zur Hausen H, de Villiers EM (1994) Ann Rev Microbiol 48: 427CrossRefGoogle Scholar
  8. 8.
    Mrowka (1912) Zbl Bakt Parasitkd 67: 249Google Scholar
  9. 9.
    Schlesinger M (1933) Biochem Z 273: 306Google Scholar
  10. 10.
    Kausche GA, Pfankuch E, Ruska H (1939) Naturwissenschoften 27: 292CrossRefGoogle Scholar
  11. 11.
    Ruska H (1941) Arch Virusforsch 2: 345CrossRefGoogle Scholar
  12. 12.
    Kleinschmidt AK, Lang D, Jacherts D, Zahn RK (1962) Biochim Biophys Acta 61: 131Google Scholar
  13. 13.
    Schlesinger M (1932) Z Hyg Infektkrankh 114: 149CrossRefGoogle Scholar
  14. 14.
    Weidel W (1958) Ann Rev Microbiol 12: 27CrossRefGoogle Scholar
  15. 15.
    Koch G, Dreyer WJ (1958) Virology 6: 291PubMedCrossRefGoogle Scholar
  16. 16.
    Stanley WM (1935) Science 81: 644PubMedCrossRefGoogle Scholar
  17. 17.
    Thomssen R (1963) Nature 198: 613PubMedCrossRefGoogle Scholar
  18. 18.
    Eggers HJ (1982) In: Handbook of Experimental Pharmacology 61: 377CrossRefGoogle Scholar
  19. 19.
    Schneweis KE, Brado M, Ebers B, Friedrich A, Olbrich M, Schüler W (1988) Med Microbiol Immunol 177: 1PubMedGoogle Scholar
  20. 20.
    Kandolf R(1993) Intervirology 35: 140Google Scholar
  21. 21.
    Bergold G (1947) Z Naturforsch 2b: 122Google Scholar
  22. 22.
    Bergold G (1948) Z Naturforsch 3b: 338Google Scholar
  23. 23.
    Schramm G (1943) Naturwissenschaften 31: 94CrossRefGoogle Scholar
  24. 24.
    Anderer FA, Uhlig H, Weber E, Schramm G (1960) Nature 186: 922PubMedCrossRefGoogle Scholar
  25. 25.
    Wittmann HG (1962) Z Vererbungslehre 93: 491Google Scholar
  26. 26.
    Gierer A, Schramm G (1956) Z Naturforsch 1 1b: 138Google Scholar
  27. 27.
    Wecker E (1959) Virology 7: 241PubMedCrossRefGoogle Scholar
  28. 28.
    Schuster H (1960) Biochem Biophys Res Commun 2: 320CrossRefGoogle Scholar
  29. 29.
    Schuster H (1961) J Mol Biol 3: 447PubMedCrossRefGoogle Scholar
  30. 30.
    Gierer A, Mundry KW (1958) Nature 182: 1457PubMedCrossRefGoogle Scholar
  31. 31.
    Anderer FA (1963) Biochim Biophys Acta 71: 246PubMedCrossRefGoogle Scholar
  32. 32.
    Schäfer W (1963) Bacteriol Rev 27: 1PubMedGoogle Scholar
  33. 33.
    Schäfer W (1955) Z Naturforsch 10b: 81Google Scholar
  34. 34.
    Klenk E, Faillard H, Lempfried H (1995) Z Physiol Chem 301: 235CrossRefGoogle Scholar
  35. 35.
    Schäfer W, Zillig W (1954) Z Naturforsch 9b: 779Google Scholar
  36. 36.
    Breitenfeld PM, Schäfer W (1957) Virology 4: 328PubMedCrossRefGoogle Scholar
  37. 37.
    Wecker E (1957) Z Naturforsch 12b: 208Google Scholar
  38. 38.
    Scholtissek C, Rott R (1963) Nature 199: 200PubMedCrossRefGoogle Scholar
  39. 39.
    Mueller GC, v Zahn-Ullmann S, Schäfer W (1960) J Biol Chem 235: 660PubMedGoogle Scholar
  40. 40.
    Rott R (1997) Berl Münch Tierärztl Wochenschr 110: 241PubMedGoogle Scholar
  41. 41.
    Klenk H-D, Garten W (1994) Trends Microbiol 2: 39PubMedCrossRefGoogle Scholar
  42. 42.
    Schwarz RT, Datema R (1980) Trends Biochem Sci 5: 65CrossRefGoogle Scholar
  43. 43.
    Veit M, Schmidt MFG (1998) Methods Mol Biol 88: 227PubMedGoogle Scholar
  44. 44.
    Klenk HD, Rott R, Orlich M, Blödorn J (1975) Virology 68: 426PubMedCrossRefGoogle Scholar
  45. 45.
    Herrler G, Rott R, Klenk H-D, Müller H-P, Schukla AK, Schauer R (1985) EMBO J 4: 1503PubMedGoogle Scholar
  46. 46.
    Graffi A, Bielka H, Frey F, Scharsch F, Weiss R (1955) Wien Klin Wochenschr 105: 61Google Scholar
  47. 47.
    Schäfer W, Bolognesi DP, de Noronha F, Fischinger PJ, Hunsmann G, Ihle JN, Moennig V, Schwarz H, Thiel H-J (1977) Med Microbiol Immunol 164: 217PubMedCrossRefGoogle Scholar
  48. 48.
    Möiling K, Bolognesi DP, Bauer H, Busen W, Plassmann HW, Hausen P (1971) Nature New Biol 234: 240CrossRefGoogle Scholar
  49. 49.
    Sänger HL (1969) J Virol 3: 304PubMedGoogle Scholar
  50. 50.
    Sänger HL (1972) Adv Biosci 8: 103Google Scholar
  51. 51.
    Sänger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK (1976) Proc Natl Acad Sci USA 73: 3852PubMedCrossRefGoogle Scholar
  52. 52.
    Domdey H, Jank P, Sänger HL, Gross HJ (1978) Nucleic Acids Res 5: 1221PubMedCrossRefGoogle Scholar
  53. 53.
    Burell CJ, Mackay P, Greenaway PJ, Hofschneider HP, Murray K (1979) Nature 279: 43CrossRefGoogle Scholar
  54. 54.
    Pasak M, Goto T, Gilbert W, Zink B, Schaller H et al. (1979) Nature 282: 575CrossRefGoogle Scholar
  55. 55.
    Will H, Cattaneo R, Koch HG, Darai G, Schaller H et al. (1982) Nature 299: 740PubMedCrossRefGoogle Scholar
  56. 56.
    Cattaneo R, Will H, Schaller H (1984) EMBO J 3: 2191PubMedGoogle Scholar
  57. 57.
    Heermann KH, Goldmann U, Schwartz W et al. (1984) J Virol 52: 396PubMedGoogle Scholar
  58. 58.
    Uy A, Bruss V, Gerlich WH, Köchel HG, Thomssen R (1986) Virology 155: 89PubMedCrossRefGoogle Scholar
  59. 59.
    Zahn P, Hofschneider PH, Koshy R (1988) Oncogene 3: 169Google Scholar
  60. 60.
    Höhne M, Schaefer S, Seifer M et al. (1990) EMBO J 9: 1 137Google Scholar
  61. 61.
    Schlüter V, Meyer M, Hof-Schneider PH et al. (1994) Oncogene 9: 3 335Google Scholar
  62. 62.
    Gissmann L, zur Hausen H (1976) Proc Natl Acad Sci USA 73: 1 310CrossRefGoogle Scholar
  63. 63.
    Gissman L, Pfister H, zur Hausen H (1976) Virology 76: 569CrossRefGoogle Scholar
  64. 64.
    Durst M, Gissmann L, Kenberg H, zur Hausen H (1983) Proc Natl Acad Sci USA 80: 3812PubMedCrossRefGoogle Scholar
  65. 65.
    Pfister H (1992) Semin Cancer Biol 3: 263PubMedGoogle Scholar
  66. 66.
    zur Hausen H (1994) Curr Topics Microbiol Immunol 186: 131CrossRefGoogle Scholar
  67. 67.
    Pfister H (1996) Obstet Gynecol Clinics 23: 579Google Scholar
  68. 68.
    Graf T, Beug H (1983) Cell 34: 7PubMedCrossRefGoogle Scholar
  69. 69.
    Donner P, Greiser-Wilke I, Moelling K (1982) Nature 296: 262PubMedCrossRefGoogle Scholar
  70. 70.
    Donner P, Bunte T, Greiser-Wilke I, Moelling K (1983) Proc Natl Acad Sci USA 80: 2 861CrossRefGoogle Scholar
  71. 71.
    Moelling K, Heimann, B, Beimling P, Rapp UR, Sander T (1984) Nature 312: 558PubMedCrossRefGoogle Scholar
  72. 72.
    Grassmann R, Dengler C, Müller-Fleckenstein I et al. (1989) Proc Natl Acad Sci USA 86: 3 351CrossRefGoogle Scholar
  73. 73.
    Jung JU, Trimble JJ, King NW et al. (1991) Proc Natl Acad Sci USA 88: 7 051CrossRefGoogle Scholar
  74. 74.
    Biesinger B, Tsygankov A, Fickenscher H et al. (1995) J Biol Chem 270: 4 729Google Scholar
  75. 75.
    Wiesmüller C, Cammenga J, Deppert W (1986) J Virol 70: 737Google Scholar
  76. 76.
    Mummenbrauer T, Janus F, Müller B et al. (1996) Cell 85: 1089PubMedCrossRefGoogle Scholar
  77. 77.
    Rott R, Orlich M, Scholtissek C (1979) J Gen Virol 44: 471PubMedCrossRefGoogle Scholar
  78. 78.
    Rott R, Klenk H-D, Nagay Y, Tashiro M (1995) Am J Resp Crit Care Med 152: 516Google Scholar
  79. 79.
    Volchkov VE, Feldmann H, Volchkova VA, Klenk H-D (1998) Proc Natl Acad Sci USA 95: 5762PubMedCrossRefGoogle Scholar
  80. 80.
    Lieben VG, Baczko K, Budka H, ter Meulen V (1986) J Gen Virol 67: 2435CrossRefGoogle Scholar
  81. 81.
    Cattaneo R, Schmidt A, Spielhofer P et al. (1989) Virology 173: 415PubMedCrossRefGoogle Scholar
  82. 82.
    Schlesinger RW, Bradshaw GL, Barbone F et al (1989) J Virol 63: 1 695Google Scholar
  83. 83.
    Watanabe R, Wege H, ter Meulen V (1983) Nature 305: 150PubMedCrossRefGoogle Scholar
  84. 84.
    Liebert VG, Lington, CC, ter Meulen V (1988) J Neuroimmunol 29: 139CrossRefGoogle Scholar
  85. 85.
    Rott O, Herzog S, Cash E (1994) Med Microbiol Immunol 183: 195PubMedCrossRefGoogle Scholar
  86. 86.
    Drzeniek R, Rott R (1969) Arch Allergy 36: 146Google Scholar
  87. 86a.
    Kochs G, Trost M, Janzen G, Haller O (1998) Methods: A companion of Methods in Enzymology 15: 255CrossRefGoogle Scholar
  88. 87.
    Koszinowski U, Thomssen R (1975) Eur J Immunol 5: 246CrossRefGoogle Scholar
  89. 88.
    Koszinowski UH, Gething AH, Waterfield MD, Klenk HD (1980) J Exp Med 151: 945PubMedCrossRefGoogle Scholar
  90. 89.
    Kurrle R, Wagner H, Röllinghoff M, Rott R (1979) Eur J Immunol 9: 107PubMedCrossRefGoogle Scholar
  91. 90.
    Lehmann-Grube F (1984) Intervirology 22: 121PubMedCrossRefGoogle Scholar
  92. 91.
    Lehmann-Grube F, Moskophidis D, Löhler J (1988) Ann NY Acad Sci 532: 238PubMedCrossRefGoogle Scholar
  93. 92.
    Narayan O, Herzog S, Frese K, Rott R (1983) Science 220: 1401PubMedCrossRefGoogle Scholar
  94. 93.
    Vallbracht A, Maier K, Stierhof YD et al. (1989) J Infect Dis 160: 209PubMedCrossRefGoogle Scholar
  95. 94.
    Pirquet Cv (1908) Dtsch Med Wochenschr 30: 1297CrossRefGoogle Scholar
  96. 95.
    Schlender J, Schnorr J-J, Spielhofer P et al. (1996) Proc Natl Acad Sci USA 93: 13194PubMedCrossRefGoogle Scholar
  97. 96.
    Hengel H, Brune W, Koszinowski U (1998) Trends Microbiol 6: 190PubMedCrossRefGoogle Scholar
  98. 97.
    Jaenisch R, Fan H, Croker B (1975) Proc Natl Acad Sci USA 72: 4 008CrossRefGoogle Scholar
  99. 98.
    Jaenisch R (1982) Hoppe-Seyer’s Z Physiol Chem 363: 1 267Google Scholar
  100. 99.
    Hofschneider PH (1960) Z Naturforsch 15b: 441Google Scholar
  101. 100.
    Amann J, Delius H, Hof-Schneider PH (1964) J Mol Biol 10: 557CrossRefGoogle Scholar
  102. 101.
    Pfeifer D (1961) Z Vererbungslehre 92: 312Google Scholar
  103. 102.
    Khatchikian D, Orlich, M, Rott R (1989) Nature 340: 156PubMedCrossRefGoogle Scholar
  104. 103.
    Eigen M, McCaskill J, Schuster P (1983) J Physiol Chem 92: 6 881Google Scholar
  105. 104.
    Sumper M, Luce R (1975) Proc Natl Acad Sci USA 72: 162PubMedCrossRefGoogle Scholar
  106. 105.
    Schaller H, Gray C, Herrmann K (1977) Proc Natl Acad Sci USA 74: 737Google Scholar
  107. 106.
    Messing J, Gronenborn B, Müller-Hill B, Hofschneider PH (1977) Proc Natl Acad Sci USA 74: 3 642CrossRefGoogle Scholar
  108. 107.
    Kuroda K, Hauser C, Rott R, Klenk H-D, Doerfler W (1986) EMBO J 5: 1 359Google Scholar
  109. 108.
    Boshart M, Weber F, Jahn G et al. (1985) Cell 41: 521PubMedCrossRefGoogle Scholar
  110. 109.
    Grosschedl R, Hobom G (1979) Nature 277: 621PubMedCrossRefGoogle Scholar
  111. 110.
    Lehrrach H, Frischauf A (1983) J Mol Biol 170: 827CrossRefGoogle Scholar
  112. 111.
    Schnell MJ, Mebastion T, Conzelmann K-K (1994) EMBO J 13: 4 195Google Scholar
  113. 112.
    Neumann G, Zobel A, Hobom G (1994) Virology 202: 477PubMedCrossRefGoogle Scholar
  114. 113.
    Messerle M, Crnkovic I, Hammerschmidt W et al. (1997) Proc Natl Acad Sci USA 94: 14 759CrossRefGoogle Scholar
  115. 114.
    Decluse H, Hilsenberger T, Pich D et al (1998) Proc Natl Acad Sci USA 95: 8 245Google Scholar
  116. 115.
    Sutter D, Westphal M, Doerfler W (1978) Ann Rev Biochem 52: 93Google Scholar

Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • R. Rott
    • 1
  1. 1.Institut für VirologieJustus-Liebig-Universität GiessenGiessenFederal Republic of Germany

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