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Retroviruses: ancient and modern

  • R. A. Weiss
  • D. Griffiths
  • Y. Takeuchi
  • C. Patience
  • P. J. W. Venables
Chapter
Part of the Archives of Virology. Supplementa book series (ARCHIVES SUPPL, volume 15)

Summary

Retroviruses are transmitted in two distinct ways: as infectious virions and as ‘endogenous’ proviral DNA integrated in the germ line of their hosts. Modern infectious viruses such as HIV recently infected mankind from simian hosts, whereas human endogenous retroviral genomes have been present throughout old world primate evolution. Recently we have characterised novel retroviruses in humans and pigs. Human retrovirus 5 (HRV-5) is detected as an exogenous genome in association with arthritis and systemic lupus erythematosus. Porcine endogenous retroviruses (PERV) are carried in swine DNA but can be activated to produce virions that are infectious for human cells, which has implications for xenotransplantation. A brief account of HRV-5 and PERV is given here.

Keywords

Systemic Lupus Erythematosus Equine Infectious Anaemia Virus Murine Mammary Tumour Virus Primary Peripheral Blood Mononuclear Cell Human Xenotransplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • R. A. Weiss
    • 1
    • 2
  • D. Griffiths
    • 1
    • 2
  • Y. Takeuchi
    • 1
    • 2
  • C. Patience
    • 1
    • 3
  • P. J. W. Venables
    • 4
  1. 1.Institute of Cancer ResearchLondonUK
  2. 2.Windeyer Institute of Medical SciencesRoyal Free & University College London Medical SchoolLondonUK
  3. 3.BioTransplant IncCharlestownUSA
  4. 4.Kennedy Institute of RheumatologyLondonUK

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