Summary
Microdialysis is an in vivo sampling technique which provides a powerful approach to monitoring metabolic events. We have performed a study to determine the feasibility and effectiveness of subcutaneous microdialysis in monitoring patients on the Neurosurgical Intensive Care Unit (NICU). A microdialysis probe was placed in the subcutaneous fat of the anterior abdominal wall and perfused with Ringer’s solution. Collecting vials were changed every 30 minutes and monitoring continued for 2–6 days. Biochemical analysis of glucose, lactate, and glutamate was correlated with clinical events. The normal ranges of glucose, lactate and glutamate were 3–6 mM, 1–2.5 mM and 5–20 μM, respectively. Periods of low tissue glucose were detected by microdialysis which were not detected by routine plasma sampling. In one patient, following an apparently brief period of hypoxia, there was a prolonged disturbance of tissue chemistry. Another patient with obesity had significantly higher concentrations of dialysate glucose, lactate and glutamate. Monitoring by subcutaneous microdialysis on intensive care units is feasible, reveals unexpected changes in tissue metabolism and might be an important adjunct for the interpretation of intracerebral data.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amer P, Bolinder J (1991) Microdialysis of adipose tissue. J Intern Med 230: 381–386
Bolinder J, Ungerstedt U, Arner P (1993) Long-term continuous glucose monitoring with microdialysis in ambulatory insulindependent diabetic patients. Lancet 342: 1080–1085
Bullock R, Zauner A, Tsuji O, Woodward JJ, Marmarou AT, Young HF (1995) Patterns of excitatory amino acid release and ionic flux after severe human head trauma. In: Tsubokawa T, Marmarou A, Robertson C, Teasdale G (eds). Neurochemical monitoring in the intensive care unit. Springer, Berlin Heidelberg New York, Tokyo, pp 64–71
Delgado JMR, DeFeudis FV, Roth RH, Ryugo DK, Mitruka BM (1972) Dialytrode for long term intracerebral perfusion in awake monkeys. Arch Int Pharmacodyn Ther 198: 9–21
Editorial (1992) Microdialysis. Lancet 339: 1326–1327
Persson L, Hillered L (1992) Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis. J Neurosurg 76: 72–80
Rosdahl H, Ungerstedt U, Jorfeldt L, Henriksson J (1993) Interstitial glucose and lactate balance in human skeletal muscle and adipose tissue studied by microdialysis. J Physiol 471: 637–657
Stallknecht B, Bulow J (1997) Does blood flow influence microdialysis probe recovery of glucose, lactate and glycerol in human subcutaneous abdominal adipose tissue? 2nd International Symposium on Clinical Microdialysis Conference Proceedings. Uppsala, Sweden
Ungerstedt U (1991) Microdialysis — principles and applications for studies in animals and man. J Intern Med 230: 365–373
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Wien
About this paper
Cite this paper
Hutchinson, P.J.A., O’Connell, M.T., Maskell, L.B., Pickard, J.D. (1999). Monitoring by Subcutaneous Microdialysis in Neurosurgical Intensive Care. In: Bullock, R., Marmarou, A., Alessandri, B., Watson, J. (eds) Neuromonitoring in Brain Injury. Acta Neurochirurgica Supplements, vol 75. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6415-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6415-0_12
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7319-0
Online ISBN: 978-3-7091-6415-0
eBook Packages: Springer Book Archive