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Part of the book series: Advances and Technical Standards in Neurosurgery ((NEUROSURGERY,volume 25))

Abstract

Hypothalamic gliomas are demanding intracranial lesions to deal with. Before the era of CT, a diagnosis of such lesions could be obtained by means of air studies and angiography. However, the diagnosis was only possible when the lesion had become large and clinically evident, and was interfering with the CSF circulation, thus causing hydrocephalus. In smaller lesions, in particular in those located only on one side of the IIIrd ventricle, the diagnosis was practically impossible since they mostly do not cause endocrinological or neurological disturbances. Histological studies of hypothalamic gliomas in the majority of cases reveal that the tumour is a pilocytic astrocytoma. The pilocytic astrocytoma in this region is a well-circumscribed tumorous lesion which, even when it is large, does not entirely destroy the hypothalamic functional tissue but, instead, mainly displaces and compresses it. The slow growth of pilocytic astrocytomas greatly contributes to the minimal occurrence of the clinical symptoms and signs. Since MRI has become available, the diagnosis of the hypothalamic gliomas has become much easier; however, the slight initial symptoms and signs of the hypothalamic lesions may easily be overlooked for a long time, and so MRI is not undertaken until the tumour has already become large.

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References

  1. Anand B, Bobeck JR (1951) Hypothalamic control of food intake in rats and cats. Yale J Biol Med 24: 123–134

    PubMed  CAS  Google Scholar 

  2. Apuzzo MLJ, Chikovani OK, Gott PS et al (1982) Transcallosal interfornical approaches for lesions affecting the third ventricle: surgical considerations and consequences. Neurosurgery 10: 547–554

    Article  PubMed  CAS  Google Scholar 

  3. Apuzzo MLJ, Giannotta SL (1987) Transcallosal interfornical approach. In: Apuzzo MLJ (ed) Surgery of the third ventricle. Williams & Wilkins, Baltimore, p 354

    Google Scholar 

  4. Bauer HG (1954) Endocrine and other clinical manifestations of hypothalamic disease: a survey of 60 cases with autopsies. J Clin Endocrinol 14: 13–31

    Article  CAS  Google Scholar 

  5. Bregeat P (1978) Quelques refléxions sur les gliomes hypothalamiques. Adv Ophthalmol 36: 130–137

    PubMed  CAS  Google Scholar 

  6. Brisman R, Chutorian AM (1970) Inappropriate antidiuretic hormone secretion. Hypothalamic glioma in a child. Arch Neurol 23: 63–69

    Article  PubMed  CAS  Google Scholar 

  7. Brooks WH, Parker JC Jr, Young AB, Mortara RH (1976) Malignant gliomas of the optic chiasm in adolescents. Clin Pediatr (Phila) 15: 557–561

    Article  CAS  Google Scholar 

  8. Carmel PW (1980) Surgical syndromes of the hypothalamus. Clin Neurosurg 27: 133–159

    PubMed  CAS  Google Scholar 

  9. Carmel PW (1985) Vegetative dysfunctions of the hypothalamus. Acta Neurochir (Wien) 75: 113–121

    Article  CAS  Google Scholar 

  10. Clar HE (1979) Clinical and morphological studies of pituitary and diencephalic space-occupying lesions before and after operation, with specific reference to temperature regulation. Acta Neurochir (Wien) 50: 153–199

    Article  CAS  Google Scholar 

  11. Cushing H (1932) Peptic ulcer and the interbrain. Surg Gynec Obstet 55: 1–34

    Google Scholar 

  12. Cushing H (1932) Pituitary body, hypothalamus, and parasympathetic nervous system. Thomas, Springfield, 111

    Google Scholar 

  13. Dolenc VV (1989) Lesion of the third ventricle and the surrounding structures. In: Holtzman RNN, Stein BM (eds) Surgery of the diencephalon. Plenum Publishing Corporation, pp 177–191

    Google Scholar 

  14. DeSousa AL, Kaisbeck JE, Mealey J Jr, Fitzgerald J (1979) Diencephalic syndrome and its relation to opticochiasmatic glioma: review of twelve cases. Neurosurgery 4: 207–209

    Article  PubMed  CAS  Google Scholar 

  15. Ehni G (1978) Transcallosal approaches to the anterior ventricular system (comment). Neurosurgery 3: 343–343

    Google Scholar 

  16. Ehni G (1984) Interhemispheric and percallosal (transcallosal) approach to the cingulate gyri, intraventricular shunt tubes and certain deeply placed brain lesions. Neurosurgery 14: 99–110

    Article  PubMed  CAS  Google Scholar 

  17. Epstein MA, Packer RJ, Rorke LB, Zimmerman RA, Goldwein JW, Sutton LN, Schut L (1992) Vascular malformation with radiation vasculopathy after treatment of chiasmatic/hypothalamic glioma. Cancer 70: 887–893

    Article  PubMed  CAS  Google Scholar 

  18. Erickson TC (1939) Neurogenic hyperthermia: a clinical syndrome and its treatment. Brain 62: 172–190

    Article  Google Scholar 

  19. Faivre J, Pecker J, Simon J, Testard R (1973) Puberté precoce et tumours du troisieme ventricule. Probl Actuels Endocrinol Nutr 16: 201–48

    PubMed  CAS  Google Scholar 

  20. Fox DH et al (1973) Spontaneous periodic hypothermia: dienephalic epilepsy. Br Med J 2: 693–695

    Article  PubMed  CAS  Google Scholar 

  21. Goel A (1995) Preoperative shunts in suprasellar tumours. Br J Neurosurg 9: 189–193

    Article  PubMed  CAS  Google Scholar 

  22. Greenwood J Jr (1973) Radical surgery of tumors of the thalamus, hypothalamus, and third ventricle area. Surg Neurol 1: 29–33

    PubMed  Google Scholar 

  23. Harper RL, Ehni G (1979) The anterior transcallosal approach to brain tumors. Adv Neurosurg 7: 91

    Google Scholar 

  24. Hasegawa H, Bitoh S, Koshino K, Obashi J, Kobayashi Y, Kobayashi M, Wakasugi C (1995) Mixed cavernous angioma and glioma (angioglioma) in the hypothalamus: case report. Neurol Med Chir 35: 238–242

    Article  CAS  Google Scholar 

  25. Heilman KM, Sypert GW (1977) Korsakoff’s syndrome resulting from bilateral fornix lesions. Neurology 27: 490–493

    Article  PubMed  CAS  Google Scholar 

  26. Helcl F, Petraskova H (1985) Gliomas of visual pathways and hypothalamus in children: a preliminary report. Acta Neurochir [Suppl] (Wien) 35: 106–110

    Article  CAS  Google Scholar 

  27. Hetherington AW, Ranson SW (1939) Experimental hypothalamic-hypophyseal obesity in the rat. Proc Soc Exp Biol Med 41: 465–476

    Google Scholar 

  28. Hoffman HJ, Humphreys RP, Drake JM, Rutka JT, Becker LE, Jenkin D, Greenberg M (1993) Optic pathway/hypothalamic gliomas: a dilemma in management. Pediatr Neurosrug 19: 186–195

    Article  CAS  Google Scholar 

  29. Honda M, Saito Y, Okada T, Hirai H, Shiobara Y (1974) Autopsy study of 2 cases of hypothalamic tumor with hypernatremia and periodic paralysis. Rinsho Shinkeigaku 14: 462–468

    PubMed  CAS  Google Scholar 

  30. Hoyt WF, Meshel LG, Lessel S, Schatz NJ, Suckling RD (1973) Malignant optic glioma of adulthood. Brain 96: 121–32

    Article  PubMed  CAS  Google Scholar 

  31. Jeeves MA, Simpson DA, Geffer G (1979) Functional consequences of the transcallosal removal of intraventricular tumors. J Neurol Neurosurg Psychiatry 42: 134–142

    Article  PubMed  CAS  Google Scholar 

  32. Kadota Y, Kondo T, Sato K (1996) Akinetic mutism and involuntary movements following radical resection of hypothalamic glioma: case report. Neurol Med Chir (Tokyo) 36: 447–450

    Article  CAS  Google Scholar 

  33. Konovalov A, Gorelyshev S, Serova N (1994) Surgery of giant gliomas of chiasma and IIIrd ventricle. Acta Neurochir (Wien) 130: 71–79

    Article  CAS  Google Scholar 

  34. Lipton JM, Rosenstein J, Sklar FH (1981) Thermoregulatory disorders after removal of a craniopharyngioma from the third ventricle. Br Res Bull 7: 369–373

    Article  CAS  Google Scholar 

  35. Long DM, Chou SN (1973) Transcallosal removal of craniopharyngiomas with the third ventricle. J Neurosurg 39: 563–567

    Article  PubMed  CAS  Google Scholar 

  36. Long DM, Leibrock C (1980) The transcallosal approach to the anterior ventricular system and its application in the therapy of craniopharyngioma. Clin Neurosurg 27: 160–168

    PubMed  CAS  Google Scholar 

  37. Long DM, Leonard AS, Story J, French LA (1962) Hypothalamus and gastric ulceration. I Gastric effects of hypothalamic lesions. Arch Neurol 7: 167–175

    Article  Google Scholar 

  38. Long DM, Leonard AS, Story J, French LA (1962) Hypothalamus and gastric ulceration. II Production of gastric ulceration by chronic hypothalamic stimulation. Arch Neurol 7: 167–183

    Article  Google Scholar 

  39. McDonnell P, Miller NR (1983) Chiasmatic and hypothalamic extension of optic nerve glioma. Arch Ophthalmol 101: 1412–1415

    Article  PubMed  CAS  Google Scholar 

  40. Morsier G de (1967) Gliome hypothalamique avec syndrome amnesique de Korsakoff. Le problème de la memoire. Ann Med Psychol (Paris) 125: 177–228

    Google Scholar 

  41. Page LK (1976) Surgical management of hypothalamic-pituitary neoplasm. In: Charyulu KK, Sudarsanam A (eds) Hormones and cancer. Stratton, New York, pp 69–85

    Google Scholar 

  42. Penfield W (1929) Diencephalic autonomic epilepsy. Arch Neurol Psychiatry 22: 358–364

    Google Scholar 

  43. Petrucci RJ, Buchheit WA, Woodruff GO et al (1987) Transcallosal para-fornical approach for third ventricle tumors: neuropsychologic consequences. Neurosurgery 20: 457–464

    Article  PubMed  CAS  Google Scholar 

  44. Ranson SW (1939) Somnolence caused by hypothalamic lesions in the monkey. Arch Neurol Psychiatry 41: 1–23

    Google Scholar 

  45. Ranson WW (1940) Regulation of body temperature. Res Publ Assoc Res Nerv Ment Dis 20: 342–399

    Google Scholar 

  46. Reeves AG, Plum F (1969) Hyperphagia, rage and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurol 20: 616–624

    Article  PubMed  CAS  Google Scholar 

  47. Ridley PT, Brooks FP (1965) Alterations in gastric secretion following hypothalamic lesions producing hyperphagia. Amer J Physiol 209: 319–323

    PubMed  CAS  Google Scholar 

  48. Russel A (1951) A diencephalic syndrome emaciation stimulation of the hypothalamus on gastric secretory activity and ulceration. Indian J Med Res 45: 205–227

    Google Scholar 

  49. Schuster H, Koos WT, Zaunbauer F (1976) Results of microsurgical treatment of gliomas of the optic system and the hypothalamus in children. Mod Probl Paediatr 18: 211–215

    PubMed  CAS  Google Scholar 

  50. Solomon GE (1973) Diencephalic autonomic epilepsy caused by a neoplasm. J Pediatr 83: 277–280

    Article  PubMed  CAS  Google Scholar 

  51. Sutton LN (1987) Current management of low-grade astrocytomas of childhood. Pediatr Neurosci 13: 98–107

    Article  PubMed  CAS  Google Scholar 

  52. Suzuki J, Katakura R, Mori T (1984) Interhemispheric approach through the lamina terminalis to tumors of the anterior part of the third ventricle. Surg Neurol 22: 157–163

    Article  PubMed  CAS  Google Scholar 

  53. Tangheroni W, Napoleone F, Cao A, Coraddu M (1967) Sindrome diencefalica cachettizzante da tumore dell’ipotalamo anteriore. Descrizione di un nuovo caso. Minerva Pediatr 19: 2331–2335

    PubMed  CAS  Google Scholar 

  54. Taphoorn MJ, Heimans JJ, van der Veen EA, Karim AB (1995) Endocrine functions in long-term survivors of low-grade supratentorial glioma treated with radiation therapy. J Neurooncol 25: 97–102

    Article  PubMed  CAS  Google Scholar 

  55. Turpin G, Metzger J, Bataini J, de Gennes JL (1979) Etude clinique, biologique, radiologique et therapeutique de 3 tumeurs hypothalamiques. Gliomes et pinealome. Ann Endocrinol (Paris) 40: 371–384

    CAS  Google Scholar 

  56. White JH, Kelly P, Dorman K (1977) Clinical picture of atypical anorexia nervosa associated with hypothalamic tumor. Am J Psychiatry 134: 323–325

    PubMed  CAS  Google Scholar 

  57. Yasargil MG (1996) Midline tumors. Microneurosurgery, of CNS tumors, pp 292, 293; 300, 301

    Google Scholar 

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© 1999 Springer-Verlag Wien

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Dolenc, V.V. (1999). Hypothalamic Gliomas. In: Cohadon, F., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 25. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6412-9_5

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  • DOI: https://doi.org/10.1007/978-3-7091-6412-9_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7318-3

  • Online ISBN: 978-3-7091-6412-9

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