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Zusammenfassung

Degenerative Erkrankungen des Herzens stehen in enger Beziehung zum Lebensalter. Sie werden bei den Menschen über 65 Jahre in bis zu 50% angetroffen und sind in dieser Bevölkerungsgruppe etwa zwei-bis dreimal häufiger als in der übrigen Bevölkerung (Abb. 10).

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Literatur

  • Abbott RD, Donahue RP, Kannel WB, Wilson PW (1988) The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study. J Am Med Assoc 260: 3456–3460

    Article  CAS  Google Scholar 

  • Akhras F, Jackson G (1991) Efficacy of nifedipine and isosorbide mononitrate im comination with atenolol in stable angina. Lancet 338: 1036–1039

    Article  PubMed  CAS  Google Scholar 

  • Akiyama T, Pawitan Y, Campbell WB, Papa L, Barker AH, Rubbert P, Friedman L, Keller M, Josephson RA, CAST-Invest (1992) Effects of advancing age on the efficacy and side effects of antiarrhytmic drugs in post-myocardial infarction patients with ventricular arrhythmia. J Am Geriatr Soc 40: 666–672

    PubMed  CAS  Google Scholar 

  • Als E, Ammer R, Lehmann G, Pütter K, Ayers GM, Pasquantonio J, Schömig A (1997) Patient characteristics and underlying heart disease as predicators of recurrent atrial fibrillation after internal and external cardioversion in patients treated with oral Sotalol. Am Heart J 134: 419–425

    Article  Google Scholar 

  • Amiodarone Trials Meta-Analysis Investigators (1997) Effect of prophylactic amiodarone on mortality after acuts myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomised trials. Lancet 350: 1417–1424

    Article  Google Scholar 

  • Andersen HR, Nielsen JC, Thomsen PEB, Thuesen L, Mortensen PT, Vesterland T, Pedersen AK (1997) Long-term follow-up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome. Lancet 350: 1210–1216

    Article  PubMed  CAS  Google Scholar 

  • Antiplatelet Trialists Collaboration (1994) Collaborative overview of randomized trials of antiplatelet therapy: 1. prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J 308: 81–106

    Article  Google Scholar 

  • Aronow WS (1997a) Treatment of congestive heart failure in older persons. J Am Geriatr Soc 45: 1252–1258

    PubMed  CAS  Google Scholar 

  • Aronow WS, Ahn C, Kronzon I (1997b) Effect of propranolol versus no Propranolol on mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction — 40% treated with diuretics plus angiotensin-converting enzyme inhibitors. Am J Cardiol 80: 207–209

    Article  PubMed  CAS  Google Scholar 

  • Aronow WS, Kronzon I (1993) Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am J Med 71: 602–604

    CAS  Google Scholar 

  • Atrial Fibrillation Investigators (1994) Risk factors for stroke and efficacy of anti-thrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized trials. Arch Intern Med 154: 1449–1457

    Article  Google Scholar 

  • Baigent C, Collins R, ISIS-2 (1993) 4-year mortality follow-up of 17187 patients after fibrinolytic and antiplatelet therapy in suspected acute myocardial infarction. Circulation 88 [Suppl I]: 291

    Google Scholar 

  • Basu S, Senior R, Raval U, van der Does R, Bruckner T, Lahiri A (1997) Beneficial effects of intravenous and oral Carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomised trial. Circulation 96: 183–191

    Article  PubMed  CAS  Google Scholar 

  • Bayer AJ, Chadha JS, Farag RR, Pathy MSJ (1986) Changing presentation of myocardial infarction with increasing old age. J Am Geriatr Soc 34: 263–266

    PubMed  CAS  Google Scholar 

  • Behar S, Boyko V, Reicher-Reiss H, Goldbourt U, for the SPRINT Study Group (1997) Ten-year survival after acute myocardial infarction: comparison of patients with and without diabetes. Am Heart J 133: 290–296

    Article  PubMed  CAS  Google Scholar 

  • Bernstein AD, Parsonnet V (1992) Survey of cardiac pacing in the United States in 1989. Am J Cardiol 69: 331–338

    Article  PubMed  CAS  Google Scholar 

  • Bharati S, Lev M (1992) The pathologic changes in the conduction system beyond the age of ninety. Am Heart J 124: 486–496

    Article  PubMed  CAS  Google Scholar 

  • Blasini R, Reiniger G, Brügmann U, Rudolph W (1984) Vermeidung einer Toleranzentwicklung unter Isosorbiddinitrat durch Intervalltherapie. Herz 9: 166–170

    PubMed  CAS  Google Scholar 

  • Blum A, Giladi M, Weinberg M, Kaplan G, Pasternack H, Laniado S, Miller H (1998) High anti-cytomegalovirus (CMV) IgG antibody titer is associated with coronary artery disease and may predict post-coronary balloon angioplasty restenosis. Am J Cardiol 81: 866–868

    Article  PubMed  CAS  Google Scholar 

  • Boushey CJ, Beresfort SAA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc 274: 1049–1057

    Article  CAS  Google Scholar 

  • Brand FN, Abbott RD, Kannel WB, Wolf PA (1985) Characteristics and prognosis of lone atrial fibrillation. J Am Med Assoc 254: 3449–3453

    Article  CAS  Google Scholar 

  • Buerke M, Pittroff W, Meyer J, Darius H (1995) Aspirin therapy: optimized platelet inhibition with different loading and maintenance doses. Am Heart J 130: 465–472

    Article  PubMed  CAS  Google Scholar 

  • Cairns JA, Gent M, Singer J, Finnie KJ, Froggatt GM, Holder DA, Jablonsky G, Kostuk WJ, Melendez LJ, Myers MG, Sackett DL, Sealey BJ, Tanser PH (1985) Aspirin, sulfinpyrazone or both in unstable angina. N Engl J Med 313: 1369–1375

    Article  PubMed  CAS  Google Scholar 

  • Cairns JA, Connolly SJ, Roberts R, Gent M (1997) Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Lancet 349: 675–682

    Article  PubMed  CAS  Google Scholar 

  • Camm AJ, Evans KE, Ward DE, Martin A (1980) The rhythm of the heart in active elderly subjects. Am Heart J 99: 598–603

    Article  PubMed  CAS  Google Scholar 

  • Carrie D, Elbaz M, Puel J, Fourcarde J, Karouny E, Fournial G, Galinier M (1997) Five-year outcome after coronary angioplasty versus bypass surgery in multivessel coronary artery disease. Circulation 96 [Suppl 2]: 1–6

    Google Scholar 

  • Castelli WP, Anderson K (1986) A population at risk. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med 80 [Suppl 2A]: 23–32

    CAS  Google Scholar 

  • Celermajer DS, Sorensen KE, Georgakopoulos D (1993) Cigarette smoking is associated with dose-related and potentially reversible impairement of endothelium-dependent dilation in healthy young adults. Circulation 88: 2149–2155

    Article  PubMed  CAS  Google Scholar 

  • Channon KM, Hargreaves MR, Cripps TR, Gardner M, Ormerod OJM (1994) DDD vs. VVI pacing in patients aged over 75 years with complete heart block: a double-blind crossover comparison. Quart J Med 87: 245–251

    PubMed  CAS  Google Scholar 

  • Chur J, Schweid A, Weiss N (1982) Survival among women with endometrial cancer: a comparison of estrogen users and nonusers. Am J Obstet Gynecol Oncol 143: 569–573

    Google Scholar 

  • Cleveland JC, Meldrum DR, Cain BS, Banerjee A, Harken AH (1997) Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Circulation 96: 29–32

    Article  PubMed  CAS  Google Scholar 

  • Cohen M, Adams PC, Parry G, Xiong J, Chamberlain D, Wieczorek I, Fox KAA, Chesebro JH, Strain J, Keller C, Kelly A, Lancaster G, Ali J, Kornmal R, Fuster V, and the Antithrombotic Therapy in Acute Coronary Syndroms Research Group (1994) Combination antithrombotic therapy in unstable rest angina and non-Q-Wave infarction in nonprior aspirin users: primary end point analysis from the ATACS trial: antithrombotic therapy in acute coronary syndromes research group. Circulation 89: 81–88

    Article  PubMed  CAS  Google Scholar 

  • Cohen M, Demers C, Gurfinkel EP (1997) A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. N Engl J Med 337: 447–452

    Article  PubMed  CAS  Google Scholar 

  • Cohen I, Wise P (1988) Effect of oestradiol on the diurnal rhythm of serotonon activity in microdissected brain areas of ovarectomized rats. Endocinrology 122: 2619–2625

    Article  CAS  Google Scholar 

  • Cohn JN (1996) The management of chronic heart failure. N Engl J Med 335: 490–498

    Article  PubMed  CAS  Google Scholar 

  • Cohn JN, Archibald DG, Ziesche S (1986) Effect of vasodilator therapy on mortality on chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med 314: 1547–1552

    Article  PubMed  CAS  Google Scholar 

  • Cohn JN, Johnson G, Ziesche S, Cobb F, Francis G, Tristani F, Smith R, Dunkman WB, Loeb H, Wong M, Bhat H, Goldman S, Fletcher RD, Diherty J, Hughes CV, Carson P, Cintron G, Shabetai R, Haakenson C (1991) A comparison of enalapril with hydralazine-isosorbid dinitrate in the treatment of congestive heart failure. N Engl J Med 325: 303–310

    Article  PubMed  CAS  Google Scholar 

  • Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE, Stampfer MJ, Hennekens C, Rosner B, Speizer FE (1995) The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 332: 1589–1593

    Article  PubMed  CAS  Google Scholar 

  • Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH (1990) Blood pressure, stroke, and coronary heart disease. Part 2. Lancet 335: 827–838

    Article  PubMed  CAS  Google Scholar 

  • Collins R, Peto R, Baigent C, Sleight P (1997) Aspirin, heparin, and fibrinolytic therapy in suspectes acute myocardial infarction. N Engl J Med 336: 847–860

    Article  PubMed  CAS  Google Scholar 

  • Colvin P, Auerbach B, Case L (1991) A dose response relationship between sex hormone induced change in hepatic triglyceride lipase and high density lipoprotein cholesterol in post menopausal women. Metabolism 40: 1052–1056

    Article  PubMed  CAS  Google Scholar 

  • Colwell JA (1997) Aspirin therapy in diabetes. Diabetes Care 20: 1767–1771

    PubMed  CAS  Google Scholar 

  • Corr PB, Gillis RA (1978) Autonomie influences in the dysrhythmia resulting from myocardial infarction. Circ Res 43: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Corti MC, Guralnik JM, Salive ME, Harris T, Field TS, Wallace RB (1995) HDL cholesterol predicts coronary heart disease mortality in older adults. J Am Med Assoc 274: 539–544

    Article  CAS  Google Scholar 

  • Corti MC, Guralnil JM, Salive ME, Harris T, Ferrucci L, Glynn RJ, Havlik RJ (1997) Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann Intern Med 126: 753–760

    PubMed  CAS  Google Scholar 

  • Cox JL, Schuessler RB, Lappas DG, Boineau JP (1996) An 8.5 year experience with surgery for atrial fibrillation. Ann Surg 224: 267–273

    Article  PubMed  CAS  Google Scholar 

  • Cruz AB, Amatuzio DS, Grnade F, Hay LJ (1961) Effect of intraarterial insulin in tissue cholesterol and fatty acids in alloxan-diabetic dogs. Circ Res 9: 39–43

    Article  PubMed  CAS  Google Scholar 

  • D’Agostino RB, Belanger AJ, Kannel WB, Cruickchank JM (199) Relation of two diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study. Br J Med 303: 385-389

    Google Scholar 

  • Dannenberg AL, Levy D, Garrison RJ (1989) Impact of age on echocardiographic left ventricular mass in a healthy population (the Framingham Study). Am J Cardiol 63: 1066–1068

    Article  Google Scholar 

  • Das DN, Fleg JL, Lakatta EG (1982) Effect of age on the components of atrioventricular conduction in normal man. Am J Cardiol 49: 1031

    Article  Google Scholar 

  • Davi G, Catalano I, Averna M (1990) Thromboxane biosynthesis and platelet function in type II diabetes mellitus. N Engl J Med 322: 1769–1774

    Article  PubMed  CAS  Google Scholar 

  • Davies MJ (1988) The pathological basis of arrhythmias. Geriatr Cardiovasc Med 1: 181–183

    Google Scholar 

  • Davis JW, Davis RF (1979) Acute effects of tobacco cigarette smoking on the platelet aggregate ratio. Am J Med Sci 278: 139–143

    Article  PubMed  CAS  Google Scholar 

  • De Bakker JM, Van Capelle FJL, Janse MJ (1988) Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. Circulation 77: 589–606

    Article  PubMed  Google Scholar 

  • de Beider MA, Linker NJ, Jones S, Camm AJ, Ward DE (1992) Cost implications of the British Pacing and Electrophysiology Groups recommendations for pacing. Br Med J 305: 861–865

    Article  Google Scholar 

  • Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, Huther ML, Richardson DW, and CAST Investigators (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. N Engl J Med 324: 781–788

    Article  PubMed  CAS  Google Scholar 

  • Edmunds LH, Stephenson LW, Edie RN, Ratcliffe MB (1988) Open-heart surgery in octogenarians. N Engl J Med 319: 131–136

    Article  PubMed  Google Scholar 

  • Elder AT, Shaw TRD, Turnball CM, Starkex IR (1991) Elderly and younger patients selected to undergo coronary angiography. Br Med J 303: 950–953

    Article  CAS  Google Scholar 

  • Ellis RW (1997) Infection and coronary heart disease. J Med Microbiol 46: 535–539

    Article  PubMed  CAS  Google Scholar 

  • European Atrial Fibrillation Trial Study Group (1992) Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia. N Engl J Med 333: 5–10

    Google Scholar 

  • Fairweather DS (1992) Aging of the heart and the cardiovascular system. Rev Clin Gerontol 2: 83–103

    Article  Google Scholar 

  • Fibrinolytic Therapy Trialists /FFT) Collaborative Group (1994) Indications for fibrinolytic therapy in suspected acute mycardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 343: 311–322

    Google Scholar 

  • Fleg JL, Kennedy HL (1982) Cardiac arryhthmias in a healthy elderly population. Chest 81: 302–307

    Article  PubMed  CAS  Google Scholar 

  • Forte P, Copland M, Smith LM, Sutherland J, Benjamin N (1997) Basal nitric oxide synthesis in essential hypertension. Lancet 349: 837–842

    Article  PubMed  CAS  Google Scholar 

  • Francis GS (1985) Neurohumoral mechanisms involved congestive heart failure. Am J Cardiol 55: 15A–21A

    Article  PubMed  CAS  Google Scholar 

  • Furberg CD (1983) Effect of antiarrhythmic drugs on mortality after myocardial infarction. Am J Cardiol 52: 32C–36C

    Article  PubMed  CAS  Google Scholar 

  • Furberg CD, Psaty BM, Meyer JV (1995) Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 92: 1326–1331

    Article  PubMed  CAS  Google Scholar 

  • Ganau A, Saba PS, Roman MJ, de Simone G, Realdi G, Devereux RB (1995) Ageing induces left ventricular concentric remodelling in normotensive subjects. J Hypertens 13: 1818–1822

    Article  PubMed  CAS  Google Scholar 

  • Gent M, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW, Panak E, Roberts RS, Sicurella J, Turpie AGG, and the CATS Group (1989) The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet i: 1215–1220

    Article  Google Scholar 

  • Gerstenblith G, Frederiksen J, Yin FCP, Fortuin NJ, Lakatta EG, Weisfeldt ML (1977) Echocardiographic assessment of a normal adult aging population. Circulation 56: 273–278

    Article  PubMed  CAS  Google Scholar 

  • Ghali JK, Cooper R, Ford E (1990) Trends in hospitalization rates for heart failure in the United States, 1973–1986. Arch Intern Med 150: 769–773

    Article  PubMed  CAS  Google Scholar 

  • Glynn RJ, Field TS, Rosner B, Hebert PR, Taylor JO, Hennekens CH (1995) Evidence for a positive linear relation between blood pressure and mortality in elderly people. Lancet 345: 825–829

    Article  PubMed  CAS  Google Scholar 

  • Gold S, Wong WF, Schatz IJ, Blanchette PL (1991) Invasive treatment for coronary artery disease in the elderly. Arch Intern Med 151: 1085–1088

    Article  PubMed  CAS  Google Scholar 

  • Goldberg RJ, Gore JM, Gurwitz JH, Alpert JS, Brady P, Strohsnitter W, Chen Z, Dalen JE (1989) The impact of age on the incidence and prognosis of initial acute myocardial infarction: The Worcester Heart Attack Study. Am Heart J 117: 543–549

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb SS, Kukin ML, Ahern D, Packer M (1989) Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure. J Am Coll Cardiol 13: 1534–1539

    Article  PubMed  CAS  Google Scholar 

  • Grady D, Rubin SM, Petitti DB, Fox CS, Black D, Ettinger B, Ernster VL, Cummings SR (1992) Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med 117: 1016–1037

    PubMed  CAS  Google Scholar 

  • Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O’Keefe J, Overlie B, Donohue B, Chelliah N, Timmis GC, Vlietastra RE, Strzelecki M, Puchrowicz-Ochocki S, Oneill WW, for the Primary Angioplasty in Myocardial Infarction Study Group (1993) A comparison of immediate angioplasty with thrombolytic therapy for myocardial infarction. N Engl J Med 328: 673–679

    Article  PubMed  CAS  Google Scholar 

  • Grodstein F, Stampfer MJ, Colditz GA, Willett WC, Manson JE, Hoffe M, Rosner B, Fuchs C, Haninsor SE, Hunter DJ, Hennekens CH, Speitzer FE (1997) Postmenopausal hormone therapy and mortality. N Engl J Med 336: 1769–1775

    Article  PubMed  CAS  Google Scholar 

  • Grossman W (1991) Diastolic dysfunction in congestive heart failure. N Engl J Med 32: 1557–1564

    Google Scholar 

  • Gum PA, O’Keefe JH, Borkon AM, Spertus JA, Bateman TM, McGraw JP, Sherwani K, Vacek J, McCallister BD (1997) Bypass surgery versus coronary angioplasty for revascularization of treated diabetic patients. Circulation 96 [Suppl 2]: 7–10

    Google Scholar 

  • Gupta S, Camm AJ (1997) Chronic infection in the etiology of atherosclerosis — the case for Chlamydia pneumoniae. Clin Cardiol 20: 829–836

    Article  PubMed  CAS  Google Scholar 

  • Hall AS, Murray GD, Ball SG, and the AIREX Study Investigators (1997) Follow-up study of patients randomly allocated ramipril of placebo for heart failure after myocardial infarction: AIRE Extrension (AIREX) Study. Lancet 349: 1493–1497

    Article  PubMed  CAS  Google Scholar 

  • Hansten PD (1979) Drug interactions. Lea & Febiger, Philadelphia, p 253

    Google Scholar 

  • Hargreaves MR, Ormerod O (1994) Physiological pacing for elderly patients: exploit the benefits but don’t overdo it. Age Ageing 23: 441–444

    Article  PubMed  CAS  Google Scholar 

  • Harrison TR, Dixon K, Russel RO, Bidwai PS, Coleman HN (1964) The relation of age to the duration of contraction, ejection and relaxation of the normal human heart. Am Heart J 67: 189

    Article  PubMed  CAS  Google Scholar 

  • Hasdai D, Garratt KN, Grill DE, Lerman A, Holmes DR (1997) Effect of smoking status on the long-term outcome after successful percutaneous coronary revascularization. N Engl J Med 336: 755–761

    Article  PubMed  CAS  Google Scholar 

  • Hawkins CM, Richardson DW, Vokonas PS, Betablocker Heart Attack Trial Group (1983) Effect of Propranolol in reducing mortality in older myocardial infarction patients. The betablocker heart attack trial experience. Circulation 57 [Suppl 1]: 94–97

    Google Scholar 

  • Heaney RP, Recker RR, Saville PD (1978) Menopausal changes in bone remodeling. J Lab Clin Med 92: 964–970

    PubMed  CAS  Google Scholar 

  • Holder DA, Jablonsky G, Kostuk WJ, Merendez LJ, Myers HG, Sackett DL, Sealey BJ, Tanser PH (1985) Aspirin sulfinpyrazone or both in unstable angina. N Engl J Med 313: 1369–1375

    Article  PubMed  Google Scholar 

  • Holland KJ, O’Neill WW, Bates ER, Pitt B, Topol EJ (1989) Emergency percutaneous transluminal coronary angioplasty during acute myocardial infarction for patients more than 70 years of age. Am J Cardiol 63: 399–403

    Article  PubMed  CAS  Google Scholar 

  • Hoorntje JC, Suryapranata H, de Boer M-J, Zijlstra F, van Hof AW, van den Brink L, ESCOBAR (1996) ESCOBAR: primary stenting for acute myocardial infarction: preliminary results of a randomized trial. Circulation 94 [Suppl 1]: 570

    Google Scholar 

  • Hunink MGM, Goldman L, Tosteson ANA, Mittleman MA, Goldman PA, Williams LW, Tsevat J, Weinstein MC (1997) The recent decline in mortality from coronary heart disease, 1980-1990. J Am Med Assoc 277: 535–542

    Article  CAS  Google Scholar 

  • ISIS-1 (First International Study of Infarct Survival) Collaborative Group (1986) Randomized trial of intravenous atenolol among 16, 027 cases of suspected acute myocardial infarction: ISIS-1. Lancet ii: 57–65

    Google Scholar 

  • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group (1988) Randomized trial of intravenous Streptokinase, oral aspirin, both, or neither among 17, 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet ii: 349–360

    Google Scholar 

  • Julian DG, Camm AJ, Frangin G, Janse M, Munoz A, Schwartz PJ, Simon P, EMIAT-Invest (1997) Randomized trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet 349: 667–674

    Article  PubMed  CAS  Google Scholar 

  • Juul-Möller S, Edvardsson N, Jahnmatz B, Rosen A, Sorensen S, Ömbius R, for the Swedish Angina Pectoris Aspirin Trial (SAPAT) Group (1992) Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable angina pectoris. Lancet 340: 1421–1425

    Article  PubMed  Google Scholar 

  • Kannel WB (1977) Prevention of heart disease in the young coronary candidate. Primary Care 4: 229–243

    PubMed  CAS  Google Scholar 

  • Kannel WB, Abbott RD, Savage DD, McNamara PM (1982) Epidemiological features of chronic atrial fibrillation. N Engl J Med 306: 1018–1022

    Article  PubMed  CAS  Google Scholar 

  • Kannel WB, Abbott RD (1984) Incidence and prognosis of unrecognized myocardial infarction. N Engl J Med 311: 1144–1147

    Article  PubMed  CAS  Google Scholar 

  • Kannel WB, Belanger AJ (1991) Epidemiology of heart failure. Am Heart J 121: 951–957

    Article  PubMed  CAS  Google Scholar 

  • Kannel WB, Wolf PA, Garrison RJ. The Framingham Study, Section 34: Some risk factors related to the annual incidence of cardiovascular disease and death using pooled repeated biannual measurements. National Institutes of Health Publication No 87-2803

    Google Scholar 

  • Kendall MJ, Lynch KP, Hjalmarson A, Kjekshus J (1995) Beta-blockers and sudden cardiac death. Ann Intern Med 123: 358–367

    PubMed  CAS  Google Scholar 

  • Kendall MJ (1997) Clinical relevance of pharmacokinetic differences between beta blockers. Am J Cardiol 80(9B): 15J–19J

    Article  PubMed  CAS  Google Scholar 

  • Kennedy HL, Whitlock JA, Sprague MK, Kennedy LJ, Buckingham TA, Goldberg RJ (1985) Longterm follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 312: 193–197

    Article  PubMed  CAS  Google Scholar 

  • Kloner R, Shook T, Przyklenk K, Davis VG, Junio L, Matthews RV, Burstein S, Gibson SM, Poole WK (1995) Previous angina alters in-hospital outcome in TIMI 4. Circulation 91: 37–47

    Article  PubMed  CAS  Google Scholar 

  • Kostis JB, Moreyra AE, Natarajan N, Gotzoyannis S, Hosier M, McCrone K, Kuo PT (1979) Ambulatory electrocardiography: what is normal? Am J Cardiol 43: 420

    Google Scholar 

  • Kostis JB, Moreyra AE, Amendo MT, Di Pietro J, Cosgrove N, Kuo PT (1982) The effect of age on heart rate in subjects free of heart disease. Circulation 65: 141–145

    Article  PubMed  CAS  Google Scholar 

  • Kostis JB, Davis BR, Cutler J, Grimm RH, Berge KG, Cohen JD, Lacy CR, Perry HM, Blaufox MD, Wassertheil-Smolle S, Black HR, Schron E, Berkson DM, Curb JD, Smith WM, McDonald R, Applegate WB, and the SHEP Cooperative Research Group (1997) Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. J Am Med Assoc 278: 212–216

    Article  CAS  Google Scholar 

  • Kusumoto FM, Goldschlager N (1996) Cardiac pacing. N Engl J Med 334: 89–98

    Article  PubMed  CAS  Google Scholar 

  • La Croix AZ, Lang J, Scherr P, Wallace RB, Cornoni-Huntley J, Berkman L, Curb JD, Evans D, Hennekens CH (1991) Smoking and mortality among older men and women in three communities. N Engl J Med 324: 1619–1625

    Article  Google Scholar 

  • Lakatta EG, Yin FCP (1982) Myocardial aging: functional alterations and related cellular mechanisms. Am J Physiol 242: H927–H941

    PubMed  CAS  Google Scholar 

  • Lakatta EG (1980) Age-related alterations in the cardiovascular response to adrenergic mediated stress. Federation Proc 39: 3173–3177

    CAS  Google Scholar 

  • Lakatta EG (1990) Similar myocardial effects of aging and hypertension. Eur Heart J 11: 29–38

    Article  PubMed  Google Scholar 

  • Lakatta EG (1993) Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 87: 631–636

    Article  PubMed  CAS  Google Scholar 

  • Laster SB, Rutherford BD, Giorgi LV, Shimshak TM, McConahay DR, Johnson WL, Huber KC, Ligon RW, Hartzler GO (1996) Results of direct percutaneous transluminal coronary angioplasty in octogenerians. Am J Cardiol 77: 10–13

    Article  PubMed  CAS  Google Scholar 

  • Le-Feuvre CA, Connolly SJ, Cairns JA, Gent M, Roberts RS (1996) Comparison of mortality from acute myocardial infarction between 1979 and 1992 in a geographically-defined stable population. Am J Cardiol 78: 1345–1349

    Article  PubMed  CAS  Google Scholar 

  • Leppo LA, O’Brien J, Rothendler JA, Getchell JD, Lee VW (1984) Dipyridamole-Thallium-201 scintigraphy in the prediction of future cardiac events acute myocardial infarction. N Engl J Med 310: 1014–1018

    Article  PubMed  CAS  Google Scholar 

  • Levine TB (1985) Role of vasidilators in the treatment of congestive heart failure. Am J Cardiol 55: 32A–35A

    Article  PubMed  CAS  Google Scholar 

  • Levy D, Wilson PWF, Anderson KM, Castelli WP (1990) Stratifying the patient at risk from coronary disease: new insights from the Framingham Heart Study. Am Heart J 119: 12–17

    Article  Google Scholar 

  • Lichtlen PR (1983) Unstabile Angina pectoris und Prä-Infarktsyndrom. Internist 24: 372–382

    PubMed  CAS  Google Scholar 

  • Lie JT, Hammond PI (1988) Pathology of the senescent heart: anatomic observations on 237 autopsy studies of patients 90 to 105 years old. Mayo Clin Proc 63: 552–564

    PubMed  CAS  Google Scholar 

  • Linzbach AJ, Akuamoa-Boateng E (1973) Die Altersveränderungen des menschlichen Herzens. Die Polypathie des Herzens im Alter. Klin Wochenschr 51: 164–175

    CAS  Google Scholar 

  • Luchi RJ, Taffe GF, Teasdale TA (1991) Congestive heart failure in the elderly. J Am Geriatr Soc 39: 810–825

    PubMed  CAS  Google Scholar 

  • MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J (1990) Blood pressure, stroke, and coronary heart disease. Part 1. Lancet 335: 765–774

    Article  PubMed  CAS  Google Scholar 

  • Malmberg K, for the DIGAMI (Diabetes mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group (1997) Prospective randomised study of intensive insulin treatment on long term survival after myocardial infarction in patients with diabetes mellitus. Br Med J 314: 1512–1515

    Article  CAS  Google Scholar 

  • Markham RV, Corbett JR, Gilmore A (1983) Efficacy of prazosin in the management of chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 51: 1346–1352

    Article  PubMed  Google Scholar 

  • Maseri A (1983) Angina pectoris: the new emerging face. Triangel 22/1: 23–30

    Google Scholar 

  • McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: The Framingham Study. N Engl J Med 285: 1441–1446

    Article  PubMed  CAS  Google Scholar 

  • Messerli FH, Michalewicz L (1997) Safety of heart rate-lowering calcium antagoniste: lessons from controlled trials. Am Heart J 134: S21–S24

    Article  PubMed  CAS  Google Scholar 

  • Miettinen TA, Pyörälä K, Olsson AG, Musliner TA, Cook TJ, Faergeman O, Berg K, Pedersen T, Kjekshus J, for the Scandinavian Simvastatin Study Group (1997) Cholesterol-lowering therapy in women and elderly patients with myocardial infarction of angina pectoris. Circulation 96: 4211–4218

    Article  PubMed  CAS  Google Scholar 

  • Mihalick MJ, Fisch C (1974) Electrocardiographic findings in the aged. Am Heart J 87: 117–128

    Article  PubMed  CAS  Google Scholar 

  • Moncada S (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002–2012

    Article  PubMed  CAS  Google Scholar 

  • Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ (1995) Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N Engl J Med 332: 1198–1203

    Article  PubMed  CAS  Google Scholar 

  • Nabulsi AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M, for the Atherosclerosis Risk in Communities Study Investigators (1993) Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. N Engl J Med 328: 1069–1075

    Article  PubMed  CAS  Google Scholar 

  • Narayan S, Cain ME, Smith JM (1997) Atrial fibrillation. Lancet 350: 943–950

    Article  PubMed  CAS  Google Scholar 

  • Nelson RD, Ezri MD, Denes P (1984) Arrhythmias and conduction disturbances in the elderly. In: Messerli FJ (ed) Cardiovascular disease in the elderly. Marinus Nijhoff, Boston, pp 83–107

    Google Scholar 

  • Nolan L, O’Malley K (1988) Prescribing for the elderly. Part I. Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 36: 142, 149

    PubMed  Google Scholar 

  • Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337: 230–236

    Article  PubMed  CAS  Google Scholar 

  • Olivetti G, Melissari M, Capasso JM, Anversa P (1991) Cardiomyopathy of the aging human heart. Circul Res 68: 1560–1568

    Article  CAS  Google Scholar 

  • Oswald GA, Corcoran S, Yudkin JS (1984) Prevalence and risks of hyperglycaemia and undiagnosed diabetes in patients with acute myocardial infarction. Lancet i: 1264–1267

    Article  Google Scholar 

  • Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH, for the U.S. Carvedilol heart failure Study Group (1996a) The effect of Carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334: 1349–1355

    Article  PubMed  CAS  Google Scholar 

  • Packer M, O’Connor CM, Ghali JK, Pressler ML, Carson PE, Belkin RN, Miller AB, Neuberg GW, Frid PE, Wertheimer JH, Cropp AB, DeMets AL, and the PRAISE Study Group (1996b) Effect of amlodipine on morbidity and mortality in severe chronic heart failure. N Engl J Med 335: 1107–1114

    Article  PubMed  CAS  Google Scholar 

  • Panotopoulos PT, Axtell K, Anderson AJ, Sra J, Blanck Z, Despande S, Biehl M, Keelan ET, Jazayeri MR, Akhtar M, Dhala A (1997) Efficacy of the implantable cardioverter-defibrillator in the elderly. J Am Coll Cardiol 29: 556–560

    Article  PubMed  CAS  Google Scholar 

  • Park KC, Forman DE, Wie JY (1995) Utility of beta-blockade treatment for older postinfarction patients. J Am Geriatr Soc 43: 751–755

    PubMed  CAS  Google Scholar 

  • Petri M, Roubenoff R, Dallai GE, Nadeau MR, Selhub J, Rosenberg IH (1996) Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet 348: 1120–1124

    Article  PubMed  CAS  Google Scholar 

  • Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania PC, Ney DE, Snavely DB, Chang PI, and the ELITE Study Investigators (1997) Randomized trial of losartan versus Captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 349: 747–752

    Article  PubMed  CAS  Google Scholar 

  • Platia EV, Michelson EL, Proterfield JK, Das G (1989) Esmolol versus Verapamil in the acute treatment of atrial fibrillation or atrial flutter. Am J Cardiol 63: 925–929

    Article  PubMed  CAS  Google Scholar 

  • Podrid PJ (1995) Amiodarone: re-evaluation of an old drug. Ann Intern Med 122: 689–700

    PubMed  CAS  Google Scholar 

  • Pomerance A (1965) Pathology of the heart with and wothout cardiac failure in the aged. Br Heart J 27: 697–710

    Article  PubMed  CAS  Google Scholar 

  • Psaty BM, Manolio TA, Kuller LH, Kronmal RA, Cushman M, Fried LP, White R, Furberg CD, Rautaharju PM (1997) Incidence of and risk factors for atrial fibrillation in older adults. Circulation 96: 2455–2461

    Article  PubMed  CAS  Google Scholar 

  • Pyärälä K, Olsson AG, Pedersen TR, Thorgeirson G, Kjekshus J, Faereman O (1997) Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. Diabetes Care 20: 614–620

    Article  Google Scholar 

  • Rakugi H, Yu H, Kamitani A, Nakamura Y, Ohishi M, Kamide K, Nakata Y, Takami S, Higaki J, Ogihara T (1996) Links between hypertension and myocardial infarction. Am Heart J 132: 213–221

    PubMed  CAS  Google Scholar 

  • Rich MW (1997) Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults. J Am Geriatr Soc 45: 968–974

    PubMed  CAS  Google Scholar 

  • Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336: 973–979

    Article  PubMed  CAS  Google Scholar 

  • Ridker PM (1998) C-reactive protein and risk of future myocardial infarction and thrombotic stroke. Europ Heart J 19: 1–3

    CAS  Google Scholar 

  • Rigby JW, Scott AK, Hawkswrth GM, Petrie JC (1985) A comparison of the pharmacokinetics of atenolol, metoprolol, oxyprenol, and propranolol in elderly hypertensive and young healthy subjects. Br J Clin Pharmacol 20: 327

    Article  PubMed  CAS  Google Scholar 

  • Rimm EB, Willet WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampder MJ (1998) Folate and vitamin B6 from diet and supplements in relation to risk of coronaryheart disease among women. J Am Med Assoc 279: 359–364

    Article  CAS  Google Scholar 

  • Ritchie JL, Phillips KA, Luft HS (1993) Coronary angioplasty: statewide experience in California. Circulation 88: 2735–2743

    Article  PubMed  CAS  Google Scholar 

  • Rodeheffer RJ, Gerstenblith G, Becker LC, Fleg JL, Weisfeldt ML, Lakatta EG (1984) Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilation and increased stroke volume compensate for diminished heart rate. Circulation 69: 203–213

    Article  PubMed  CAS  Google Scholar 

  • Ross T (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801–809

    Article  PubMed  CAS  Google Scholar 

  • Rotmensch HH, Belhassen B (1988) Amiodarone in the management of cardiac arrhythmias: current concepts. Med Clin North Am 72: 321–358

    PubMed  CAS  Google Scholar 

  • Rupprecht H-J, Darius H, Meyer J (1997) Aktuelle Therapie der koronaren Herzkrankheit. Internist 38: 1179–1190

    Article  PubMed  CAS  Google Scholar 

  • Savage MP, Douglas JS, Fischman DL (1997) Stent placement compared with balloon angiopasty for obstructed coronary bypass grafts. N Engl J Med 337: 740–747

    Article  PubMed  CAS  Google Scholar 

  • Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study (48). Lancet 344: 1383–1389

    Google Scholar 

  • Schocke DD (1992) Cardiac disease. Rev Clin Gerontol 2: 207–226

    Article  Google Scholar 

  • Schrör K (1995) Antiplatelet drugs. A comparative review. Drugs 50: 7–28

    Article  PubMed  Google Scholar 

  • Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. I Am Med Assoc 270: 2693–2698

    Article  CAS  Google Scholar 

  • Serruys PW, Herrman J-PR, Simon R, Rutsch W, Bode C, Laarman G-J, van Dijk R, van den Bos AA, Umans VAWM, Fox KAA, Close P, Deckers JW, for the HELVETICA Investigators (1995) A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. N Engl J Med 333: 757–763

    Article  PubMed  CAS  Google Scholar 

  • Setaro JF, Zaret BL, Schulman DS (1990) Usefulness of Verapamil for congestive heart failure associated with abnormal left ventricular distolic filling and normal left ventricular systolic performance. Am J Cardiol 66: 981–986

    Article  PubMed  CAS  Google Scholar 

  • SHEP Cooperative Research Group (1991) Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. J Am Med Assoc 265: 3255–3264

    Article  Google Scholar 

  • Shepard J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ, for the West of Scotland Coronary Prevention Study Group (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterinemia. N Engl J Med 333: 1301–1307

    Article  Google Scholar 

  • Shetty IIGM, Woodhouse KW (1992) Use of amiodarone for elderly patients. Age Ageing 21: 233–236

    Article  PubMed  CAS  Google Scholar 

  • Simoons ML, de Boer MJ, van den Brand MJBM, van Miltenbrug AJM, Horrntje JCA, Hendrickx GR, van der Wieken LR, De Bono D, Rutsch W, Schaible TF, Weisman HE, Klootwijk P, Nijssen KM, Stibbe J, Feyter PJ, and the European Cooperative Study Group (1994) Randomized trial of GP IIb/IIIa platelet receptor blocker in refractory unstable angina. Ciruclation 89: 596–603

    Article  CAS  Google Scholar 

  • Singer DE, Moulton AW, Nathan DM (1989) Diabetic myocardial infarction. Interaction of diabetes with other preinfarction risk factors. Diabetes 38: 350–357

    CAS  Google Scholar 

  • Singh BN (1990) Advantages of beta-blockers versus anti-arrhythmic agents and calciumantagonstits in secondary prevention after myocardial infarction. Am J Cardiol 66: 9C–20C

    Article  PubMed  CAS  Google Scholar 

  • Singh BN (1991) Principles of pharmacologic and nonpharmacologic therapy. In: Weiss JN (ed) Ventricular arrhythmias in ischemic heart disease. Ann Intern Med 114: 784–797 (792-795)

    Google Scholar 

  • Slany J (1984) Akuter Myokardinfarkt beim alten Menschen. Fortschr Med 102: 507–511

    PubMed  CAS  Google Scholar 

  • Sorbini CA, Grassi V, Solinas E, Muiesan G (1968) Arterial oxygen tension in relation to age in healthy subjects. Respiration 25: 3–13

    Article  PubMed  CAS  Google Scholar 

  • Stampfer MJ, Malinow MR, Willet WC, Newcomer LM, Upson B, Ullman D, Tishler PV, Hennekens CH (1992) A prospective study of plasma homocystein and risk of myocardial infarction in US physicians. J Am Med Assoc 268: 877–881

    Article  CAS  Google Scholar 

  • Stanord L, Weiss N, Voigt L, Daling J, Habel L, Rossing M (1995) Combined oestrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle aged women. J Am Med Assoc 274: 178–179

    Article  Google Scholar 

  • Stratton JR, Cerqueria MD, Schwartz RS, Levy WC, Veith RC, Kahn SE, Abrass IB (1992) Differences in cardiovascular responses to isoproterenol in relation to age and exercise training in healthy men. Circulation 86: 504–512

    Article  PubMed  CAS  Google Scholar 

  • Sutton R (1988) The use of cardiac pacemakers. Geriatr Cardiovascular Med 1: 197–199

    Google Scholar 

  • Swedberg K, Held P, Kjekhus J, Rasmussen K, Ryden I, Wedel H, the CONSENSUS II Study Group (1992) Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. N Engl J Med 327: 678–684

    Article  PubMed  CAS  Google Scholar 

  • Sytkowski PA, Kannel WB, De Agostino RB (1990) Changes in risk factors and the decline in mortality from cardiovascular disease: the Framingham Heart Study. N Engl J Med 322: 1635–1641

    Article  PubMed  CAS  Google Scholar 

  • Tan KH, Sulke N, Taub N, Karani S, Sowton E (1995) Percutaneous transluminal coronary angioplasty in patients 70 years of age or older: 12 years experience. Br Heart J 74: 310–317

    Article  PubMed  CAS  Google Scholar 

  • Task Force of the Working Group on Arrhythmias of the European Society of Cardiology (1994) The early termination of clinical trials: causes, consequences, and control, with special reference to trials in the field of arrhythmias and sudden death. Circulation 89: 2892–2907

    Article  Google Scholar 

  • Teirstein PS (1998) Radiotherapy to inhibit coronary restenosis: kind of a light at the end of the tunnel. Europ Heart J 19: 3–6

    CAS  Google Scholar 

  • Teo K, Yusuf S, Furberg C (1993) Effect of antiarrhythmic drug therapy in acute myocardial infarction: an overview of results from randomized controlled trials. J Am Med Assoc 270: 1589–1595

    Article  CAS  Google Scholar 

  • The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators (1994) The effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342: 821–828

    Google Scholar 

  • The Bypass Angioplasty Revascularization Investigation (BARI) Investigators (1996) Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med 335: 271–275

    Google Scholar 

  • The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure. N Engl J Med 316: 1429–1435

    Article  Google Scholar 

  • The Digitalis Investigation Group (1997) The effect of dogoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336: 525–533

    Article  Google Scholar 

  • The EPIC Investigators (1994) Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 330: 956–961

    Article  Google Scholar 

  • The EPILOG Investigators (1997) Platelet glycoprotein IIb/IIIa receptor blockade and lowdose heparin during percutaneous coronary revascularization. N Engl J Med 336: 1689–1696

    Article  Google Scholar 

  • The Global Use of Strategies to Open occluded coronary arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators (1997) A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 336: 1621–1628

    Article  Google Scholar 

  • The GUSTO-IIb Investigators (1996) A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 335: 775–782

    Article  Google Scholar 

  • The Multicenter Postinfarction Research Group (1983) Risk stratification and survival after myocardial infarction. N Engl J Med 309: 331–336

    Article  Google Scholar 

  • The Norwegian Multicenter Study (1981) Tmilolinduced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 304: 801–807

    Article  Google Scholar 

  • The Pooling Project Research Group (1978) Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the Pooling Project. J Chron Dis 31: 201–306

    Article  Google Scholar 

  • Topol EJ, Califf RM (1992) Thrombolytic therapy for elderly patients. N Engl J Med 327: 45–47

    Article  PubMed  CAS  Google Scholar 

  • Topol EJ, Fuster V, Harrington RA, Califf RM, Kleiman NS, Kereiakis DJ, Cohen M, Chapekis A, Gold HK, Tannenbaum NA, Rao AK, Debowey D, Schwartz D, Henis M, Chesebro J (1994) Recombinant hirudin for unstable angina pectoris. A multicenter randomized angiographic trial. Circulation 89: 1557–1566

    Article  PubMed  CAS  Google Scholar 

  • Tragl KH (1983) Risikofaktoren und atherosklerotische Komplikationen in Wien: Herzinfarkt und Schlaganfall. Acta Med Austr 10: 1–10

    CAS  Google Scholar 

  • Tresch DD, McGough MF (1995) Heart failure with normal systolic function: a common disorder in older people. 1 Am Geriatr Soc 1035-1042

    Google Scholar 

  • Tresch DD (1997) The clinical diagnosis of heart failure in older patients. J Am Geriatr Soc 45: 1128–1133

    PubMed  CAS  Google Scholar 

  • Tröster S, Schuster H-P, Bodmann KF (1991) Vorhofflimmern bei Patienten einer medizinischen Klinik — ein Marker für Multimorbidität und ungünstige Prognose. Med Klinik 86: 338–343

    Google Scholar 

  • Tsai TP, Matloff JM, Chaux A, Kass RM, Lee ME, Czer LSC, DeRobertis RN, Gray RJ (1986) Combined valve and coronary artery bypass procedures in septuagenerians and octogenerians: results in 120 patients. Ann Thorac Surg 42: 681–684

    Article  PubMed  CAS  Google Scholar 

  • Vigilante GJ, Weintraub WS, Klein LW, Schneider RM, Seelaus PA, Parr GVS, Agarwal JB, Heltant RH (1986) Medical and surgical survival in coronary artery disease in the 1980s. Am J Cardiol 58: 926–931

    Article  PubMed  CAS  Google Scholar 

  • Voigt L, Weiss N, Chu J, Daling J, McKnight B, van Belle G (1991) Progestagen supplementation of exogenous oestrogens and the risk of endometrial cancer. Lancet 338: 274–277

    Article  PubMed  CAS  Google Scholar 

  • Waldo AL, Camm AJ, de Ruyter H, Friedman PL, McNeil DJ, Pauls JF, Pitt B, Pratt CM, Schwartz PJ, Veltri EP, for the SWORD Investigators (1996) Effect of Sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 348: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Wallen T, Landahl S, Hedner T, Hall C, Saito Y, Nakao K (1997) Atrial natriuretic peptides predict mortality in the elderly. J Intern Med 241: 269–275

    Article  PubMed  CAS  Google Scholar 

  • Waller BF, Roberts WC (1983) Cardiovascular disease in the very elderly. Am J Cardiol 51: 403–421

    Article  PubMed  CAS  Google Scholar 

  • Wie JY (1992) Age and the cardiovascular system. N Engl J Med 327: 1735–1739

    Article  Google Scholar 

  • Weigner MJ, Caulfield TA, Danias PG, Silverman DI, Manning WJ (1997) Risk for clinical thromboembolism associated with conversion to sinus rhythm in patients with atrial fibrillation lasting less than 48 hours. Ann Intern Med 126: 615–620

    PubMed  CAS  Google Scholar 

  • Willett W, Hennekens CH, Castelli W (1983) Effects of cigarette smoke on fasting triglyceride, total cholesterol, and HDL-cholesterol in women. Am Heart J 105: 417–421

    Article  PubMed  CAS  Google Scholar 

  • Willett WC, Green A, Stampfer MJ, Speizer FE, Colditz GA, Rosner B, Monson RR, Stason W, Hennekens CH (1987) Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med 317: 1303–1309

    Article  PubMed  CAS  Google Scholar 

  • Xiao RP, Lakatta EG (1991) Mechanism of altered beta-adrenergic modulation of the cardiovascular system with aging. Rev Clin Gerontol 1: 309–322

    Article  Google Scholar 

  • Yin FC, Raizes GS, Guarnieri T, Spurgeon HA, Lakatta EG, Fortuin NJ, Weisfeldt ML (1978) Age-associated decrease in ventricular response to haemodynamic stress during betaadrenergic blockers. Br Heart J 40: 1349–1355

    Article  PubMed  CAS  Google Scholar 

  • Yusuf S, Collins R, MacMahon S, Peto R (1988) Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials. Lancet i: 1088–1092

    Article  Google Scholar 

  • Zijlstra F, de Boer MJ, Horrntje JCA, Reiffers S, Reiber JHC, Suryapranata H (1993) A comparison of immediate coronary angioplasty with intravenous Streptokinase in acute myocardial infarction. N Engl J Med 328: 680–684

    Article  PubMed  CAS  Google Scholar 

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Tragl, K.H. (1999). Das Herz des alternden Menschen. In: Handbuch der Internistischen Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6409-9_5

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