Skip to main content
SpringerLink
Log in

Knochenstoffwechsel und Osteoporose

  • Chapter
Handbuch der Internistischen Geriatrie

  • 44 Accesses

Zusammenfassung

Kalzium gehört zu den wichtigsten Elementen des menschlichen Organismus. Es besitzt für viele Funktionen (Blutgerinnung, Muskelkontraktion u.v.a.m.) eine entscheidende Bedeutung und ist für die Statik des Knochens unverzichtbar. Aus diesen Gründen unterliegt die Regulation das Kalziumspiegels im Blut vielfältigen und feinen Regulationsmechanismen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aarskog D, Aksens L, Lehmann V (1980) Low 1, 25-dihydroxyvitamin D in heparin-induced osteopenia. Lancet ii: 650–651

    Article  Google Scholar 

  • Adinoff AD, Hollister JR (1983) Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med 309: 265–268

    Article  PubMed  CAS  Google Scholar 

  • Aredia Breast Cancer Study Group (1996) Efficacy of Pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N Engl J Med 335: 1785–1791

    Article  Google Scholar 

  • Armbrecht HJ (1990) Effect of age on calcium and phosphate absorption: role of 1, 25-dihydroxy vitamin D. Miner Electrolyte Metab 16: 159–166

    PubMed  CAS  Google Scholar 

  • Aubin R, Menard P, Lajeunesse D (1996) Selective effect of thoazides on the human osteoblastlike cell line MG-63. Kidney Int 50: 1476–1482

    Article  PubMed  CAS  Google Scholar 

  • Bardin CW, Swerdloff RS, Santen RJ (1991) Androgens: risks and benefits. J Clin Endocrinol Metab 73: 4–7

    Article  PubMed  CAS  Google Scholar 

  • Baron DT, Teitelbaum SL, Bergfeld MA, Parker G, Cruvant EM, Aviolo EV (1980) Effect of alcohol ingestion on bone and mineral metabolism in rats. Am J Physiol 238: E507–E510

    Google Scholar 

  • Basle MF, Mauras Y, Audran M, Clochon P, Rebel A, Allain P (1990) Concentration of bone elements in osteoporosis. J Bone Miner Res 5: 41–47

    Article  PubMed  CAS  Google Scholar 

  • Baum HBA, Biller BMK, Finkelstein JS, Cannistraro KB, Oppenheim DS, Schoenfeld DA, Michel TH, Wittink H, Klibanski A (1996) Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. Ann Intern Med 125: 883–890

    PubMed  CAS  Google Scholar 

  • Benz DJ, Haussler MR, Thomas MA, Speelman B, Komm BS (1991) High-affinity androgen binding and androgenic regulation of alpha-1(I)-procollagen and transforming growth factorbeta steady-state messenger RNA levels in human osteoblast-like osteosarcoma cells. Endocrinology 128: 2723–2730

    Article  PubMed  CAS  Google Scholar 

  • Binkle NC, Suttie JW (1995) Vitamin K nutrition and osteoporosis. J Nutr 125: 1812–1821

    Google Scholar 

  • Boonen S, Lesaffre E, Dequeker J, Aerssens J, Nijs J, Pelemans W, Bouillon R (1996) Relationship between baseline insulin-like growth factor-I (IGF-I) and femoral bone density in women aged over 70 years: potential implications for the prevention of age-related bone loss. J Am Geriatr Soc 44: 1301–1306

    PubMed  CAS  Google Scholar 

  • Bottermann P (1994) Moderne Behandlung der primären Osteoporose. Internist 35: 1105–1116

    PubMed  CAS  Google Scholar 

  • Briggs MH (1973) Cigarette smoking and infertility in men. Med J Austr 1: 616–617

    CAS  Google Scholar 

  • Bröll H (1996) A clinical survey of osteoporosis. In: Bröll H, Dambacher MA (eds) Osteoporosis: a guide to diagnosis and treatment. Karger, Basel

    Google Scholar 

  • Bronner F (1989) Renal calcium transport: mechanism and regulation. Am J Physiol 257: F707–F711

    PubMed  CAS  Google Scholar 

  • Brown JP, Malaval J, Chapuy MC, Delmas PD, Edouard D, Meunier PJ (1984) Serum bone GLA-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet ii: 1091–1093

    Article  Google Scholar 

  • Chapuy MC, Chapuy P, Meunier PJ (1987) Calcium and vitamin D supplements: effects on calcium metabolism in elderly people. Am J Clin Nutr 46: 324–328

    PubMed  CAS  Google Scholar 

  • Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ (1992) Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327: 1637–1642

    Article  PubMed  CAS  Google Scholar 

  • Colditz G, Hankinson S, Hunter J, Willett W, Manson J, Stampfer M, Hennekens C, Rosner B, Speizer F (1991) The use of oestrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 332: 274–277

    Google Scholar 

  • Compston JE (1992) Risk factors for osteoporosis. Clin Endocrinol 36: 223–224

    Article  CAS  Google Scholar 

  • Consensus Development Conference (1991) Conference Report: prophylaxis and treatment of osteporosis. Osteoporosis Int 1: 114–117

    Article  Google Scholar 

  • Dawson-Hughes B, Dallai GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323: 878–883

    Article  PubMed  CAS  Google Scholar 

  • Delmas PD (1996) Biphosphonates in the treatment of bone diseases. N Engl J Med 335: 1836–1837

    Article  PubMed  CAS  Google Scholar 

  • Dempster DW, Lindsay R (1993) Pathogenesis of osteoporosis. Lancet 341: 797–801

    Article  PubMed  CAS  Google Scholar 

  • Douglas AS, Robins SP, Hutchinson JD, Proter RW, Stewart A, Reid DM (1995) Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone 17: 15–20

    Article  PubMed  CAS  Google Scholar 

  • Duursma SA, Slootweg MC, Bijlsma JWJ (1988) How does oestrogen prevent postmenopausal osteoporosis? In: Bergener M, Ermini M, Stähelin HB (eds) Crossroads in aging. Academic Press, New York

    Google Scholar 

  • Duursma SA, Raymakers JA, Scheven BAA, Jansen PAF (1993) Osteoporosis. Rev Clin Gerontol 3: 135–146

    Article  Google Scholar 

  • Eastell R, Yergey AL, Vieira NE (1991) Interrelationship among vitamin D metabolism, true calcium absorption parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1, 25-dihydroxyvitamin D action. J Bone Miner Res 6: 125–132

    Article  PubMed  CAS  Google Scholar 

  • Eriksen EF, Mosekilde L, Meisen F (1985) Trabecular bone remodeling and bone balance in hyperthyroidism. Bone 6: 421–428

    Article  PubMed  CAS  Google Scholar 

  • Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL (1988) Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241: 84–86

    Article  PubMed  CAS  Google Scholar 

  • Ernst M, Schmid C, Froesch ER (1988) Enhanced Osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci 85: 2307–2310

    Article  PubMed  CAS  Google Scholar 

  • Farley JR, Wergedal JE, Baylink DJ (1983) Fluoride directly stimulates proliferation and alkaline Phosphatase activitiy of bone-forming cells. Science 227: 320–332

    Google Scholar 

  • Finkelstein JS, Neer RM, Biller BMK, Crawford JD, Klibanski JA (1992) Osteopenia in men with a history of delayed puberty. N Engl J Med 326: 600–604

    Article  PubMed  CAS  Google Scholar 

  • Gloth FM, Gundberg CM, Hollis BW, Haddad JG, Tobin JD (1995) Vitamin D deficiency in homebound elderly persons. J Am Med Assoc 274: 1683–1686

    Article  Google Scholar 

  • Goodman CE (1985) Osteoporosis: protective measures of nutrition and exercise. Geriatics 40/4: 59–70

    Google Scholar 

  • Grey AB, Stapleton JP, Evans MC, Tatneil MA, Reid IR (1996) Effect of hormone replacement therapy on bone mineral density in postmenopausal women with mild primary hyperparathyroidism. Ann Intern Med 125: 360–368

    PubMed  CAS  Google Scholar 

  • Griffith GC, Nichols G, Asher JD, Flanagan B (1965) Heparin osteoporosis. J Am Med Assoc 193: 85–88

    Article  Google Scholar 

  • Grynpas MD, Cheng PT (1988) Fluoride reduces the rate of dissolution of bone. Bone Miner 5: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Hahn TJ, Halsstead LR, Baran DT (1981) Effects of short-term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 42: 111–115

    Article  Google Scholar 

  • Heaney RP, Recker RR, Saville PD (1978) Menopausal changes in bone remodeling. J Lab Clin Chem 92: 964–970

    CAS  Google Scholar 

  • Hock JM, Centrella M, Canalis E (1988) Insulinlike growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122: 254–260

    Article  PubMed  CAS  Google Scholar 

  • Hodgkinson A, Thompson T (1982) Measurement of the fasting urinary hydroxyproline: Creatinine ratio in normal adults and its variation with age and sex. J Clin Pathol 35: 807–811

    Article  PubMed  CAS  Google Scholar 

  • Holick MF, Matsuoka LY, Wortsman J (1989) Age, vitamin D, and solar ultraviolet. Lancet ii: 1104–1105

    Article  Google Scholar 

  • Jensen J, Christiansen C, Rodbro P (1985) Cigarette smoking, serum estrogens and bone loss during hormone-replacement therapy early after menopause. N Engl J Med 313: 973–975

    Article  PubMed  CAS  Google Scholar 

  • Jilka RL, Hangoc G, Girasole G, Passen G, Williams D, Abrams J, Broxmeyer H, Manolagas SC (1992) Increased osteoclast development after estrogen loss: mediation by Interleukin 6. Science 257: 88–91

    Article  PubMed  CAS  Google Scholar 

  • Joborn C, Ljunghall S, Larsson K, Lindh E, Naessen T, Wide L, Akerström G, Rastaad J (1991) Skeletal responsiveness to parathyroid hormone in healthy females: relationship to menopause and oestrogen replacement. Clin Endocrinol 34: 335–339

    Article  CAS  Google Scholar 

  • Kanis JA, Johnell O, Gullberg B, Allander E, Dilsen G, Gennari C, Vaz AA, Lyritis GP, Mazzuoli G, Miravet L, Passen M, Cano RP, Rapado A, Ribot C (1992) Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture. Br Med J 305: 1124–1128

    Article  CAS  Google Scholar 

  • Kannus P, Palvanen M, Niemi S, Parkkari J, Järvinen M, Vuori I (1996) Increasing number and incidience of osteoporotic fractures of the proximal humerus in elderly people. Br Med J 313: 1051–1052

    Article  CAS  Google Scholar 

  • Kannus P, Parkkari J, Niemi S (1995) Age-adjusted incidence of hip fracture. Lancet 346: 50–51

    Article  PubMed  CAS  Google Scholar 

  • Karpf DB, Shapiro DR, Seeman E, Ensrud KE, Johnston CC, Adami S, Harris ST, Santora AC, Hirsch LJ, Oppenheimer L, Thompson D (1997) Prevention of nonvertebral fractures by alendronat. J Am Med Assoc 277: 1159–1164

    Article  CAS  Google Scholar 

  • Kasperk CH, Ziegler R (1992) Androgene und Knochenstoffwechsel. Dtsch Med Wochenschr 117: 990–996

    Article  PubMed  CAS  Google Scholar 

  • Krexner E, Resch H, Pietschmann P, Bernecker P, Wolosczuk W, Vukovich Th, Geyer G, Willvonseder R (1996) Vitamin D status in residents of a long-term-care geriatric hospital in Vienna. Osteologie 5: 13–18

    Google Scholar 

  • Krischker U, Frank A, Schröter T, Donath G (1994) Wertigkeit der Osteodensitometrie mittels peripheren quantitativen CT am distalen Radius zur Frühdiagnose der präklinischen Osteoporose. Prävent Rehab 6: 60–64

    Google Scholar 

  • Kurokawa K (1996) How is plasma calcium held constant? Milieu interieur of calcium. Kidney Int 49: 1760–1764

    Article  PubMed  CAS  Google Scholar 

  • Lewis AF (1981) Fracture of the neck of the femur: changing incidence. Br Med J 283: 1217–1220

    Article  CAS  Google Scholar 

  • Lindsay R, Nievers J (1994) Milk and bones. You are what you drink. Br Med J 308: 930–931

    Article  CAS  Google Scholar 

  • Lukert BP, Raisz LG (1990) Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 112: 352–364

    PubMed  CAS  Google Scholar 

  • Lyritis GP, Tsakalakos N, Magiasus B, Karachalios T, Yatzides A, Tsekoura M (1991) Analgesic effect of salmon calcitonin in osteoporotic vertebral fractures: a double-blind placebocontrolled clinical study. Calcif Tissue Int 49: 369–372

    Article  PubMed  CAS  Google Scholar 

  • Marie PJ, DeVernejoul MC, Lomri A (1992) A stimulation of bone formation in osteoporosis patients treated with flouride associated with increased DNA synthesis by osteoblastic cells in vitro. J Bone Miner Res 7: 103–113

    Article  PubMed  CAS  Google Scholar 

  • McCarthy TL, Centrella M, Canalis E (1989) Regulatory effects of insulin-like growth factors I and II on bone collagene synthesis in rat calvarial cultures. Endocrinology 124: 301–309

    Article  PubMed  CAS  Google Scholar 

  • Menon RK, Gill DS, Thomas M, Kernoff PB, Dandona P (1987) Impaired carboxylation of osteocalcin in warfarin-treated patients. J Clin Endocrinol Metab 64: 59–61

    Article  PubMed  CAS  Google Scholar 

  • Moore EW (1970) Ionized calcium in normal serum, ultrafiltrates and whole blood determined by ion-exchange electrodes. J Clin Invest 39: 318–320

    Article  Google Scholar 

  • Mosekilde L (1996) Can we influence the degenerative diseases (osteoporosis and Osteoarthritis)? In: Viidik A, Hofecker G (eds) Vitality, mortality and ageing. Facultas, Wien

    Google Scholar 

  • Murphy S, Khaw K-T, Prentice A, Compstone JE (1993) Relationship between parathyroid hormone, 25-hydroxyvitamin D, and bone mineral density in elderly men. Age Ageing 22: 198–204

    Article  PubMed  CAS  Google Scholar 

  • Murphy S, Khaw KT, May H, Compton JE (1994) Milk consumption and bone mineral density in middle aged and elderly women. Br Med J 308: 939–941

    Article  CAS  Google Scholar 

  • Need AG, Durbridge TC, Nordin BEC (1993) Anabolic steroids in postmenopausal osteoporosis. Wien Med Wochenschr: 392-395

    Google Scholar 

  • Nicolas V, Prewett A, Mohan S, Finkelman RD, Baylink DJ, Farley JR (1994) Age-related decreases in insulin-like growth factor-I and transforming growth factor-ß in femoral cortical bone from both men and women: implications for bone loss with aging. J Clin Endocrinol Metab 78: 1011–1016

    Article  PubMed  CAS  Google Scholar 

  • Nordin BEC (1989) Calcium requirement and the menopause. Med J Aust 141: 114–119

    Google Scholar 

  • Ott SM (1992) Estrogen therapy for osteoporosis. Even in the elderly. Ann Intern Med 117: 85–86

    CAS  Google Scholar 

  • Pak CY, Sakhaee K, Piziak V, Peterson RD, Breslau NA, Boyd P (1994) Slow release sodium fluoride in the management of postmenopausal osteoporosis. A randomized controlled trial. Ann Intern Med 120: 625–632

    PubMed  CAS  Google Scholar 

  • Persson I, Adami H, Bergkvist L (1989) Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study. Br Med J 298: 147–151

    Article  CAS  Google Scholar 

  • Philip WJ, Martin JC, Richardson JM, Reid DM, Webster J, Douglas AS (1995) Decreased axial and peripheral bone density in patients taking long-term warfarin. Q J Med 88: 635–640

    CAS  Google Scholar 

  • Prince RL, Smith M, Dick IM, Price RI, Webb PG, Henderson NK, Harris MM (1990) Prevention of postmenopausal osteoporosis: a comparative study of exercise, calcium supplementation, and hormone replacement therapy. N Engl J Med 325: 1189–1195

    Article  Google Scholar 

  • Reginster TY, Deroisy R, Albert A (1989) Relationship between whole plasma calcitonin levels, calcitonin secretion capacity, and plasma levels of estron in healthy women and postmenopausal osteoporotics. J Clin Invest 83: 1073–1077

    Article  PubMed  CAS  Google Scholar 

  • Reginster JY (1991) Effect of calcitonin on bone mass and fracture rate. Am J Med 91: 19–22

    Article  Google Scholar 

  • Reid IR (1989) Pathogenesis and treatment of steroid osteoporosis. Clin Endocrinol 30: 83–103

    Article  CAS  Google Scholar 

  • Riggs BL, Melton LJ (1986) Involutional osteoporosis. N Engl J Med 314: 1676–1684

    Article  PubMed  CAS  Google Scholar 

  • Riggs BL, Hodgson SF, O’Fallou WM, Chao EYS, Wachner H, Muhs JM, Cedel SL, Melton JL (1990) Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 332: 802–809

    Article  Google Scholar 

  • Riggs BL, Melton LJ (1992) The prevention and treatment of osteoporosis. N Engl J Med 327: 620–627

    Article  PubMed  CAS  Google Scholar 

  • Ringe JD, Kruse HP, Kuhlencordt F (1982) Natriumfluorid und Calzium zur Therapie der primären Osteoporose. Med Klin 77: 86–89

    Google Scholar 

  • Resch A, Schneider B, Bernecker P, Battmann A, Wergedal J, Willvonseder R, Resch H (1995) Risk of vertebral fractures in men: relationship to mineral density of the vertebral body. Am J Radiol 164: 1447–1450

    CAS  Google Scholar 

  • Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP (1981) Impaired growth hormone secretion in the adult population. J Clin Invest 67: 1361–1369

    Article  PubMed  CAS  Google Scholar 

  • Rutherford OM, Jones DA (1992) The relationship of muscle and bone loss and activity levels with age in women. Age Ageing 21: 286–293

    Article  PubMed  CAS  Google Scholar 

  • Scane AC, Francis RM (1993) Riskfactors for osteoporosis in men. Clin Endocrinol 38: 15–16

    Article  CAS  Google Scholar 

  • Schneider DL, Barrett-Connor EL, Morton DJ (1997) Timing of postmenopausal estrogen for optimal bone mineral density. J Am Med Assoc 277: 543–547

    Article  CAS  Google Scholar 

  • Sherman SS, Hollis BW, Tobin JD (1990) Vitamin D status and related parameters in a healthy population. The effects of age, sex and season. J Clin Endocrinol Metab 71: 405–413

    CAS  Google Scholar 

  • Smith R (1996) Investigation of osteoporosis. Clin Endocrinol 44: 371–374

    Article  CAS  Google Scholar 

  • Smith R (1993) Molecular, cellular and metabolic mechanisms of osteoporosis. Rev Clin Gerontol 3: 107–116

    Article  Google Scholar 

  • Stampfer MJ, Colditz GA (1988) Estrogen replacement therapy and coronary heart disease, a quantitative assessment of the epidemiologic evidence. Prev Med 17: 201–223

    Article  Google Scholar 

  • Storm T, Thamsborg G, Steiniche T, Genant HK, Soerensen OH (1990) Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322: 1265–1271

    Article  PubMed  CAS  Google Scholar 

  • Wasnich R, Davis J, Ross P, Vogel J (1990) Effect of thiazide on rates of bone mineral loss: a longitudinal study. Br Med J 301: 1303–1305

    Article  CAS  Google Scholar 

  • Watts NB, Harris ST, Genant HK, Wasnich RD, Miller PD, Jackson RD, Licata AA, Ross P, Woodson GC, Yanover MJ, Mysinde WJ, Kohre L, Rao MB, Steiger P, Richmond B, Chesmont CH (1990) Intermittend cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med 323: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB (1984) Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug therapy. J Clin Endocrinol Metab 58: 1003–1009

    Article  PubMed  CAS  Google Scholar 

  • Wilson RJ, Rao DS, Ellis B, Kleerekoper M, Parfitt AM (1988) Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral fractures. Ann Intern Med 109: 959–962

    PubMed  CAS  Google Scholar 

  • Wingo P, Lee N, Ory H, Beral V, Peterson H, Rhodes P (1993) Age specific differences in the relationship between oral contraceptive use and breast cancer. Cancer 71/4: 1506–1517

    Article  Google Scholar 

  • Writing Group for the PEPI Trial (1996) Effects of hormone therapy on bone mineral density. J Am Med Assoc 276: 1389–1396

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Medizinischen Abteilung, Donauspitals, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

  2. Ludwig-Boltzmann-Institutes für Altersforschung, Donauspital, Langobardenstraße 122, A-1220, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

Authors
  1. Univ.-Prof. Dr. Karl Heinz Tragl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Wien

About this chapter

Cite this chapter

Tragl, K.H. (1999). Knochenstoffwechsel und Osteoporose. In: Handbuch der Internistischen Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6409-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6409-9_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7317-6

  • Online ISBN: 978-3-7091-6409-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation