Skip to main content
SpringerLink
Log in
Book cover

Handbuch der Internistischen Geriatrie pp 203–243Cite as

Glukosetoleranz und Diabetes mellitus im Alter

  • Chapter

  • 44 Accesses

Zusammenfassung

Die Glukosetoleranz eines gesunden Menschen wird von vielen Faktoren bestimmt. Unter anderen modifizieren der Fett- und Muskelanteil am Körpergewicht und das Ausmaß der körperlichen Aktivität die Fähigkeit des Organismus, über eine Kohlenhydratbelastung zu disponieren. Der mit dem Lebensalter zunehmende Nüchternblutzucker gibt den ersten Hinweis für den möglichen Einfluß des Alters auf die Kohlehydrattoleranz (Spence 1920).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   69.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abbasi F, Carantonie M, Kamath V, Chen Y-DI, Rizvi AA, Reaven GM (1997) Results of a placebo-controlled study of the metabolic effects of the addition of metformin to sulfonylureatreated patients. Diabetes Care 20: 1863–1869

    Article  PubMed  CAS  Google Scholar 

  • Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL (1997) Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 46: 1473–1480

    Article  PubMed  CAS  Google Scholar 

  • Akasaka T, Yoshida K, Hozumi T, Takagie G, Kaji S, Kawamoto T, Morioka S, Yoshikawa J (1997) Retinopathy identifies marked restriction of coronary blood flow reserve in patients with diabetes mellitus. J Am Coll Cardiol 30: 935–941

    Article  PubMed  CAS  Google Scholar 

  • Alberti KG, Johnson AB, Taylor R (1992) Gliclazide: metabolic and vascular effects — a perspective. Metabolism 41: 40–45

    Article  PubMed  CAS  Google Scholar 

  • Antonucci T, McLain R, Whitcomb R, Lockwood D (1997) Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglizazone. Diabetes Care 20: 188–193

    Article  PubMed  CAS  Google Scholar 

  • Arieff AI, Caroll HJ (1972) Nonketotic hyperosmolar coma with hyperglycemia: clinical features, pathophysiology, renal function, acid-base balance, plasma-cerebrospinal fluid equilibrium and the effects of therapy in 37 cases. Medicine 51: 73–94

    Article  PubMed  CAS  Google Scholar 

  • Aronson D, Rayfield EJ, Chesebro JH (1997) Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction. Ann Intern Med 126: 296–306

    PubMed  CAS  Google Scholar 

  • BARI Investigators (1997) Influence of diabetes on 5-year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease. Circulation 96: 1761–1769

    Article  Google Scholar 

  • Bennett PH (1984) Diabetes in the elderly: diagnosis and epidemiology. Geriatrics 39/5: 37–41

    Google Scholar 

  • Berger M, Baumhoff E, Gries FA (1976) Gewichtsreduktion und Glukose-Intoleranz bei Adipositas. Dtsch Wochenschr 101: 307–311

    Article  CAS  Google Scholar 

  • Berger W, Sonnenberg GE (1980) Blutzuckertagesprofile und Hämoglobin A1 bw. A1c zur Überwachung der Diabetesbehandlung. Schweiz Med Wochenschr 110: 485–491

    PubMed  CAS  Google Scholar 

  • Bernbaum M, Albert SG, McGinnis J, Brusca S, Mooradian AD (1994) The reliability of self blood glucose monitoring in elderly diabetic patients. J Am Geriatr Soc 42: 779–781

    PubMed  CAS  Google Scholar 

  • Bijlstra PJ, Lutterman JA, Russel FGM, Thien T, Smits P (1996) Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans. Diabetologia 39: 1083–1090

    Article  PubMed  CAS  Google Scholar 

  • Blunt BA, Barrett-Connor E, Wingard DL (1991) Evaluation of fasting plasma glucose as screening test for NIIDM in older adults. Rancho Bernardo Study. Diabetes Care 14: 989–993

    Article  PubMed  CAS  Google Scholar 

  • Bolinder J, Östmann J, Arner P (1983) Influence of aging on insulin receptor binding and metabolic effects of insulin on human adipose tissue. Diabetes 32: 959–964

    Article  PubMed  CAS  Google Scholar 

  • Braunwald E (1997) Shattuck Lecture — cardiovascular medicine at the turn of the millenium: triumphs, concerns, and opportunities. N Engl J Med 337: 1360–1369

    Article  PubMed  CAS  Google Scholar 

  • Bretzel RG (1997) Effects of antihypertensive drugs on renal function in patients with diabetic nephropathy. Am J Hypertension 10: 208S–217S

    Article  CAS  Google Scholar 

  • Cacciatori V, Dellera A, Bellavere F, Bongiovanni LG, Teatini F, Gemma ML, Muggeo M (1997) Comparative assessment of peripheral sympathetic function by postural vasoconstriction ateriolar reflex and sympathetic skin response in NIDDM patients. Am J Med 102: 365–370

    Article  PubMed  CAS  Google Scholar 

  • Cahill GF, McDevitt HO (1981) Insulin-dependent diabetes mellitus: the initial lesions. N Engl J Med 304: 1454–1465

    Article  PubMed  Google Scholar 

  • Cameron NE, Cotter MA (1997) Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 46 [Suppl 2]: S31–S37

    PubMed  CAS  Google Scholar 

  • Chantelau E, Spraul M (1986) Der diabetische Fuß. Internist Welt 7: 230–236

    Google Scholar 

  • Cleveland JC, Melrum DR, Cain BS, Banerjee A, Harken AH (1997) Oral sulfonylurea hypoglycemic agents prevent ischemie preconditioning in human myocardium. Circulation 96: 29–32

    Article  PubMed  CAS  Google Scholar 

  • Cortis M-C, Guralnik JM, Salive ME, Harris T, Ferrucci L, Glynn RJ, Havlik RJ (1997) Clarifying the direct relation between total cholesterol levels and death from coronary heart disease in older persons. Ann Intern Med 126: 753–760

    Google Scholar 

  • DeFronzo RA (1979) Glucose intolerance and aging. Diabetes 28: 1095–1101

    PubMed  CAS  Google Scholar 

  • DeFronzo RA (1997) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity hypertension, dyslipidemia and atherosclerosis. Neth J Med 50: 191–197

    Article  PubMed  CAS  Google Scholar 

  • Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977–986

    Article  Google Scholar 

  • Dudl RJ, Ensinck JW (1977) Insulin and glucagon relationship during aging in man. Metabolism 26: 33–41

    Article  PubMed  CAS  Google Scholar 

  • Eastman RC, Keen H (1997) The impact of cardiovascular disease on people with diabetes: the potential for prevention. Lancet 350 [Suppl 1]: 29–32

    Article  Google Scholar 

  • Edmonds ME, Roberts VC, Watkins PJ (1982) Blood flow in the diabetic neuropathic foot. Diabetologia 22: 9–15

    Article  PubMed  CAS  Google Scholar 

  • Egger ThP, Tragi KH, Schernthaner G, Prager R (1985) Glukosetoleranz und Alter: Untersuchungen der Insulinsekretion, der Insulinrezeptorbindung und in vivo Insulinsensitivität. Klin Wochenschr 63 [Suppl 4]: 80

    Google Scholar 

  • Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS (1997) Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metabol 82: 2108–2116

    Article  CAS  Google Scholar 

  • Eliason M, Jansson JH, Nilsson P, Asplund K (1997) Increased levels of tissue Plasminogen activator antigen in essential hypertension. A population-based study in Sweden. J Hypertens 15: 349–356

    Article  Google Scholar 

  • Esposito C, Gerlach H, Brett J, Stern H, Vlassara H (1989) Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties. J Exp Med 170: 1387–1407

    Article  PubMed  CAS  Google Scholar 

  • Expert Committee on the Diagnosis and Classification of Diabetes mellitus (1997) Report. Diabetes Care 20: 1183–1197

    Google Scholar 

  • Feinglos MN, Bethel MA, Thacker CH, Lane JD, English J (1997) Modification of postprandial hyperglycemia with insulin lispro improves glucose control in patients with typ-2-diabetes. Diabetes Care 20: 1539–1542

    Article  PubMed  CAS  Google Scholar 

  • French LR, Goetz FC, Martinez AM, Boen JR, Bushhouse SA, Sprafka JM (1992) Association between stimulated plasma C-peptide and age: the Wadena city health study. J Am Geriatr Soc 40: 309–315

    PubMed  CAS  Google Scholar 

  • Gale EAM, Dornan TL, Tattersall RB (1981) Severely uncontrolled diabetes in the over fifties. Diabetologia 21: 25–28

    Article  PubMed  CAS  Google Scholar 

  • Gall M-A, Hougaard P, Borch-Johnson K, Parving H-H (1997) Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: prospective, observational study. Br Med J 314: 783–788

    Article  CAS  Google Scholar 

  • Gilde JL, Hendryx M, Casia C, Singh SP (1989) The effectivenes of diabetes education programs for older patients and their spouses. J Am Geriatr Soc 37: 1023–1030

    Google Scholar 

  • Gradman TJ, Laws A, Thompson LW, Reaven GM (1993) Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 41: 1305–1312

    PubMed  CAS  Google Scholar 

  • Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson J (1990) Cardiovascular risk factors in confirmed prediabetic individuals. J Am Med Assoc 263: 2893–2898

    Article  CAS  Google Scholar 

  • Haffner SM, Miettinen H (1997) Insulin resistance implications for type II diabetes mellitus and coronary heart disease. Am J Med 103: 152–162

    Article  PubMed  CAS  Google Scholar 

  • Hall JE (1997) Mechanisms of abnormal renal sodium handling in obesity hypertension. Am J Hypertens 10: 49S–55S

    Article  PubMed  CAS  Google Scholar 

  • Hanssen KF (1997) Blood glucose and microvascular and macrovascular complications in diabetes. Diabetes 46 [Suppl 2]: S101–S103

    PubMed  CAS  Google Scholar 

  • Harris MI, Hadden WC, Knower WC, Bennett PH (1987) Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20–74 yr. Diabetes 36: 523–534

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto Y, Futamura A, Ikushima M (1995) Effect of aging on HbA1c in a working male Japanese population. Diabetes Care 18: 1337–1340

    Article  PubMed  CAS  Google Scholar 

  • Hebert PR, Gaziano JM, Chan KS, Hennekens CH (1997) Cholesterol lowering with statin drugs, risk of stroke, and total mortality. J Am Med Assoc 278: 313–321

    Article  CAS  Google Scholar 

  • Heine RJ (1996) Role of sulfonylureas in noninsulin-dependent diabetes mellitus: part II — „the cons“. Horm Metab Res 28: 522–526

    Article  PubMed  CAS  Google Scholar 

  • Hellman R, Regan J, Rosen H (1997) Effect of intensive treatment of diabetes on the risk of death or renal failure in NIDDM and IDDM. Diabetes Care 20: 258–264

    Article  PubMed  CAS  Google Scholar 

  • Heimlich SP, Ragland DR, Leung RW, Paffenbarger RS (1991) Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 325: 147–152

    Article  Google Scholar 

  • Holleman F, Hoekstra JBL (1997) Insulin Lispro. N Engl J Med 337: 176–183

    Article  PubMed  CAS  Google Scholar 

  • Hollenbeck C, Reaven GM (1987) Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64: 1169–1173

    Article  PubMed  CAS  Google Scholar 

  • ISIS-2 Collaborative Group (1988) Randomised trial of intravenous Streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction. Lancet ii: 349–360

    Google Scholar 

  • Janssens J, Peeters TL, Vantrappen G, Tack J, Urbain JL, DeRoo M, Muls F. Boullon R (1990) Improvement of gastric emptying in diabetic gastroparesis by erythromycin. N Engl J Med 322: 1028–1031

    Article  PubMed  CAS  Google Scholar 

  • Johnson AB, Webster JM, Sum C-F (1993) The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight typ II diabetic patients. Metabolism 42: 1217–1222

    Article  PubMed  CAS  Google Scholar 

  • Johnson KC, Graney MJ, Applegate WB, Kitabchi AE, Runyan JW, Shorr RI (1997) Prevalence of undiagnosed non-insulin-dependent diabetes mellitus and impaired glucose tolerance in a cohort of older persons with hypertension. J Am Geriatr Soc 45: 695–700

    PubMed  CAS  Google Scholar 

  • Julian-Vague I, Alessi MC (1997) PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb Haemost 78: 656–660

    Google Scholar 

  • Kannel WB, Hjortland M, Castelli WP (1974) Role of diabetes on congestive heart failure: the Framingham Study. Am J Cardiol 34: 29–34

    Article  PubMed  CAS  Google Scholar 

  • Kannel WB, McGee DL (1979) Diabetes and cardiovascular disease. J Am Med Assoc 241: 2035–2038

    Article  CAS  Google Scholar 

  • Klein R, Klein BFK, Moss SE, Cruickshanks KJ (1994) Relationship of hyperglycemia to the long-term incidence and progression of diabetic retinopathy. Arch Intern Med 154: 2169–2178

    Article  PubMed  CAS  Google Scholar 

  • Klein R, Klein BEK, Moss SE (1996) Relation of glycemic control to diabetic microvascular complications in diabetes mellitus. Ann Intern Med 124: 90–96

    PubMed  CAS  Google Scholar 

  • Kleinberger G (1985) Therapie der schweren diabetischen Stoffwechselentgleisung (Coma diabeticum). Wien Med Wochenschr 135: 159–170

    PubMed  CAS  Google Scholar 

  • Kotsanos JG, Marrero D, Vignati L, Mathias SD, Huster W, Patrick D, Andrejasich C, Zalani S, Boggs MB, Anderson J, Jacobson AM (1997) Health-related quality-of-life results from multinational clinical trials of insulin lispro. Diabetes Care 20: 948–958

    Article  PubMed  CAS  Google Scholar 

  • Krendel DA, Costigan DA, Hopkins LC (1995) Successful treatment of neuropathies in patiens with diabetes mellitus. Arch Neurol 52: 1053–1061

    Article  PubMed  CAS  Google Scholar 

  • Krolewski AS, Laffel LMB, Krolewski M, Quinn M, Warram JH (1995) Glycosylated hemoglobin and the risk of mikroalbuminuria in patients wih insulin-dependent diabetes mellitus. N Engl J Med 332: 1251–1255

    Article  PubMed  CAS  Google Scholar 

  • Kumar S, Durrington PN, Bhatnagar D, Laing I (1994) Suppression of non-etsreified fatty acids to treat type a Insulin resistance syndrome. Lancet 343: 1073–1074

    Article  PubMed  CAS  Google Scholar 

  • Lehmann ED, Riley WA, Clarkson P, Gosling RG (1997) Non-invasive assessment of cardiovascular disease in diabetes mellitus. Lancet 350 [Suppl 1]: 14–19

    Article  Google Scholar 

  • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD (1993) The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy. N Engl J Med 329: 1456–1462

    Article  PubMed  CAS  Google Scholar 

  • Lippert J, Ritz E, Schwarzbeck A, Schneider P (1995) The rising tide of end-stage renal failure from diabetic nephropathy type II — an epidemiological analysis. Nephral Dial Transplant 10: 462–467

    CAS  Google Scholar 

  • LoGerfo FW, Coffman JD (1984) Vascular and mikrovascular disease of the foot in diabetic implications for foot care. N Engl J Med 311: 1615–1619

    Article  PubMed  CAS  Google Scholar 

  • Lunt H (1996) Diabetes mellitus in older patients. Is tight blood glucose control warranted? Drugs Aging 8: 401–407

    Article  PubMed  CAS  Google Scholar 

  • Lyons TJ (1992) Lipoprotein glycation and its metabolic consequences. Diabetes 41 [Suppl 2]: 67–73

    PubMed  CAS  Google Scholar 

  • Malhotra A, Sanghi V (1997) Regulation of contractile proteins in diabetic heart. Cardiovasc Res 34: 34–40

    Article  PubMed  CAS  Google Scholar 

  • Malik RA (1997) The pathology of human diabetic neuropathy. Diabetes 46 [Suppl 2]: S50–S53

    PubMed  CAS  Google Scholar 

  • Malone ML, Gennis V, Goodwin JS (1992) Characterization of diabetic ketoacidosis in older versus younger adults. J Am Geriatr Soc 40: 1100–1104

    PubMed  CAS  Google Scholar 

  • Mathiesen ER, Hommel E, Giese J, Parving H-H (1991) Efficacy of Captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. Br Med J 303: 81–87

    Article  CAS  Google Scholar 

  • Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R (1992) Effects of desipramine, amitrityline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 326: 1250–1256

    Article  PubMed  CAS  Google Scholar 

  • Meigs JB, Singer DE, Sullivan LM, Dukes KA, De Agostino RB, Nathan DM, Wagner EH, Kaplan SH, Greenfield S (1997) Metabolic control and prevalent cardiovascular disease in non-insulin-dependent diabetes mellitus (NIDDM): the NIDDM patient outcomes research team. Am J Med 102: 38–47

    Article  PubMed  CAS  Google Scholar 

  • Messerli FH, Grossman E, Michalewicz L (1997) Combination therapy and target organ protection in hypertension and diabetes mellitus. Am J Hypertension 10: 198S–201S

    Article  CAS  Google Scholar 

  • Monnier LH, Blotman MJ, Colette C, Monnier MP, Mirouze J (1981) Effects of dietary fibre supplementation in stable and labile insulin-dependent diabetes. Diabetologia 20: 12–17

    Article  PubMed  CAS  Google Scholar 

  • Monnier VM, Glomb M, Elgawish A, Sell DR (1996) The mechanism of collagen cross-linking in diabetes: a puzzle nearing resolution. Diabetes 45 [Suppl 3]: S67–S72

    PubMed  CAS  Google Scholar 

  • Morishita E, Asakura H, Jokaji H, Saito M, Uotani C, Kumabashiri I, Yamazaki M, Aoshima K, Hashimoto T, Matsuda T (1996) Hypercoagulability and high lipoprotein (a) levels in patients with type II diabetes mellitus. Atherosclerosis 120: 7–14

    Article  PubMed  CAS  Google Scholar 

  • Morrish NJ, Stevens LK, Head J, Fuller JH, Jarrett RJ, Keen H (1990) A prospective study of mortality among middle-aged, diabetic patients (the London cohort of the WHO Multinational Study of vascular disease in diabetics) I: causes and death rates. Diabetologia 33: 538–541

    Article  PubMed  CAS  Google Scholar 

  • Mueller MJ, Strube MJ, Allen BT (1997) Therapeutic footwear can reduce plantar pressures in patients with diabetes and transmetatarsal amputation. Diabetes Care 20: 637–641

    Article  PubMed  CAS  Google Scholar 

  • Muller DC, Elahi D, Tobin JD, Andres R (1996) The effect of age on insulin resistance and secretion: a review. Semin Nephral 16: 289–298

    CAS  Google Scholar 

  • Nagi, DK, Yudkin JS (1993) Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and Plasminogen activator inhibitor in NIDDM sujects: a study of two ethnic groups. Diabetes Care 16: 621–629

    Article  PubMed  CAS  Google Scholar 

  • Naliboff BD, Gilmore SL, Rosenthal MJ (1993) Acute autonomic responses to postural change, Valsalva maneuver, and paced breathing in older typ II diabetic men. J Am Geriatr Soc 41: 648–653

    PubMed  CAS  Google Scholar 

  • Nathan DM, Singer DE, Godine JE, Harrington CH, Perlmuter LC (1986) Retinopathy in older type II diabetics: association with glucose control. Diabetes 35: 797–801

    Article  PubMed  CAS  Google Scholar 

  • Nathan DM (1993) Long-term complications of diabetes mellitus. N Engl J Med 328: 1676–1685

    Article  PubMed  CAS  Google Scholar 

  • Nathan DM (1996) The pathophysiology of diabetic complications: how much does the glucose hypothesis explain? Ann Intern Med 124 (1 pt 2):86–89

    PubMed  CAS  Google Scholar 

  • National Diabetes Data Group (NDDG) (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039–1057

    Google Scholar 

  • Nichols CG, Ripoll C, Lederer WJ (1991) ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contraction. Circ Res 68: 280–287

    Article  PubMed  CAS  Google Scholar 

  • Nielsen FS, Rossing P, Gall M-A, Smidt UM, Chen JW, Sato A, Parving H-H (1997) Lisinopril improves endothelial dysfunction in hypertensive NIDDM subjects with diabetic nephropathy. Scand J Clin Lab Invest 57: 427–434

    Article  PubMed  CAS  Google Scholar 

  • Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM (1994) Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of NIDDM and obesity. J Clin Endocrinol Metab 78: 471–477

    Article  PubMed  CAS  Google Scholar 

  • Oki JC (1995) Dyslipidaemia in patients with diabetes mellitus: classification and risks and benefits of therapy. Pharmacotherapy 15: 317–337

    PubMed  CAS  Google Scholar 

  • Oskarsson P, Ljunggren JG, Lins PE (1997) Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy. The Mexiletine Study Group. Diabetes Care 20: 1594–1597

    Article  PubMed  CAS  Google Scholar 

  • Osterby R, Gall M-A, Schmitz A, Nielsen FS, Nyberg G, Parving H-H (1993) Glomerular structure and function in Proteinurie type-2 (non-insulin-dependent) diabetic patients. Diabetologia 36: 1064–1070

    Article  PubMed  CAS  Google Scholar 

  • Paillole C, Dahan M, Paycha F, Solal AC, Passa P, Gourgon R (1989) Prevalence and significance of left ventricular filling abnormalities determined by Doppler echocardiography in young type I (Insulin dependent) diabetic patients. Am J Cardiol 64: 1010–1016

    Article  PubMed  CAS  Google Scholar 

  • Panzram G (1973) Epidemiologie des Coma diabeticum. Schweiz Med Wochenschr 103: 203–208

    PubMed  CAS  Google Scholar 

  • Panzram G, Zabel-Langhennig R (1981) Prognosis of diabetes mellitus in a geographically defined population. Diabetologia 20: 587–591

    Article  PubMed  CAS  Google Scholar 

  • Paton RC (1981) Haemostatic changes in diabetic coma. Diabetologia 21: 172–177

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer MA, Schumer MP, Gelber DA (1997) Aldose reductase inhibitors: the end for an era or the need for differential trial designs? Diabetes 46 [Suppl 2]: S82–S89

    PubMed  CAS  Google Scholar 

  • Pfeiffer A, Spranger J, Meyer-Schwickerath R, Schatz H (1997) Growth factor alterations in advanced diabetic retinopathy: a possible role of blood retina barrier breakdown. Diabetes 46 [Suppl 2]: S26–S30

    PubMed  CAS  Google Scholar 

  • Piatti PM, Monti LD, Davis SN, Conti M, Brown MD, Pozza G, Alberti KGMM (1996) Effects of an acute decrease in non-esterified fatty acid levels in muscle glucose utilisation and forearm indirect calorimetry in lean NIDDM patients. Diabetologia 39: 103–112

    PubMed  CAS  Google Scholar 

  • Prachar H, Bruneder H, Nobis H, Korp W (1975) Coma diabeticum. Bericht über 752 Fälle (1931 bis 1973). Münch Med Wochenschr 117: 661–668

    CAS  Google Scholar 

  • Pugh JA, Medina E, Ramirez M (1993) Comparison of the course to end-stage renal disease of type-1-(insulin-dependent) and type-2-(noninsulin-dependent) diabetic nephropathy. Diabetologia 36: 1094–1098

    Article  PubMed  CAS  Google Scholar 

  • Pyörälä K, Olsson AG, Pedersen TR, Thorgeirsson G, Kjekshus J, Faergeman O (1997) Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. Diabetes Care 20: 614–620

    Article  PubMed  Google Scholar 

  • Randle P, Hales CN, Garland PB, Newsholme EA (1963) The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i: 785–789

    Article  Google Scholar 

  • Rayfield EJ, Ault MJ, Keusch GT, Brothers MJ, Nechemias C, Smith H (1982) Infection and diabetes: the case for glucose control. Am J Med 72: 439–450

    Article  PubMed  CAS  Google Scholar 

  • Reaven GM (1985) Beneficial effect of moderate weight loss in older patients with non-insulindependent diabetes mellitus poorly controlled with insulin. J Am Geriatr Soc 33: 93–95

    PubMed  CAS  Google Scholar 

  • Reaven GM (1988) Banting lecture. Role of insulin resistance in human disease. Diabetes 37: 1595–1607

    Article  PubMed  CAS  Google Scholar 

  • Rimoin DL, Rotter JI (1984) The genetics of diabetes mellitus. In: Andreani D, Federlin KF, DiMario U, Heding LG (eds) Immunology in diabetes. Klimpton, London, p 63

    Google Scholar 

  • Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE (1985) Production of insulin resistance by hyperinsulinaemia in man. Diabetologia 28: 70–75

    PubMed  CAS  Google Scholar 

  • Roßkamp R, Wernicke-Panten K, Draeger E (1996) Clinical profile of the novel sulphonylurea glimepiride. Diab Res Clin Pract 31 [Suppl]: S33–S42

    Article  Google Scholar 

  • Said G, Goulon-Goeau C, Lacroix C, Moulonguet A (1994) Nerve biopsy findings in different patterns of proximal diabetic neuropathy. Ann Neurol 35: 559–569

    Article  PubMed  CAS  Google Scholar 

  • Sandouk T, Reda D, Hofmann C (1993) The antidiabetic agent pioglitazone increases expression of glucose transporters in 3T3-F442A cells by increasing messenger-RNA-transcript stability. Endocrinology 133: 352–359

    Article  PubMed  CAS  Google Scholar 

  • Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the SSS-Study. Lancet 344: 1383–1389

    Google Scholar 

  • Schernthaner H (1985) Ätiologie und Pathogenese des Syndroms Diabetes mellitus. Wien Med Wochenschr 135: 139–145

    PubMed  CAS  Google Scholar 

  • Schöffling K, Hillebrand I (1981) Acarbose — ein neues therapeutisches Prinzip in der Behandlung des Diabetes mellitus. Dtsch Med Wochenschr 106: 1083–1084

    Article  PubMed  Google Scholar 

  • Segal P, Rybka J, Feig PU, Petzinna D, Schernthaner G, Berlin C, Ratzmann KP (1997) The efficacy and safety of miglitol therapy compared with gliben-clamide in patients with NIDDM inadequately controlled by diet alone. Diabetes Care 20: 687–691

    Article  PubMed  CAS  Google Scholar 

  • SHEP Cooperative Research Group (1991) Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the SHEP. J Am Med Assoc 265: 3255–3264

    Article  Google Scholar 

  • Shimizu M, Kato N, Kawazu S, Ishii C, Tomono S, Ito Y, Ohno T, Murata K, Utsugi T (1996) Agerelated alteration of pancreatic beta-cell function. Diabetes Care 19: 8–11

    Article  PubMed  CAS  Google Scholar 

  • Shorr RI, Ray WA, Daugherty JR, Griffin MR (1996) Individual sulfonylureas and serious hypoglycemia in older people. J Am Geriatr Soc 44: 751–755

    PubMed  CAS  Google Scholar 

  • Siegel RD, Cupples A, Schaefer EJ, Wilson PW (1996) Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham offspring study. Metabolism 45: 1267–1272

    Article  PubMed  CAS  Google Scholar 

  • Singer DE, Moulton AW, Nathan DM (1989) Diabetic myocardial infarction: interaction of diabetes with other preinfarction risk factors. Diabetes 38: 350–357

    Article  PubMed  CAS  Google Scholar 

  • Simonson DC, De Fronzo RA (1983) Glucagon physiology and aging: evidence for enhanced hepatic sensitivity. Diabetologia 25: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Sirtori C, Fraceschini G, Galli-Kienle M, Cighetti G, Galli G, Bondioli A, Conti F (1978) Disposition of metformin (NN-dimethylbiguanide) in man. Clin Pharmacol Ther 24: 683–693

    PubMed  CAS  Google Scholar 

  • Skyler JS, Beatty CM, Goldberg RB (1984) Managing diabetes: an updated look at diet. Geriatrics 39/7: 57–68

    Google Scholar 

  • de Sonnavile JJ, Colly LP, Wijkel D, Heine RJ (1997) The prevalance and determinants of foot ulceration in type II diabetic patients in a primary health care setting. Diab Res Clin Pract 35: 149–156

    Article  Google Scholar 

  • Spallone V, Menzinger G (1997) Diagnosis of cardiovascular autonomic neuropathy in diabetes. Diabetes 46 [Suppl 2]: S67–S76

    PubMed  CAS  Google Scholar 

  • Spence JC (1920/21) Some observations on sugar tolerance, with special reference to variations found at different ages. Quart J Med 14: 314–326

    Article  Google Scholar 

  • Stewart J, Collier A, Patrick AW, Clarke BF, Weir DM (1991) Alterations in monocyte receptor function in type I diabetic patients with ketoacidosis. Diabet Med 8: 213–216

    Article  PubMed  CAS  Google Scholar 

  • Stolk RP, Pols HAP, Lamberts SWJ, Dejong PTVM, Hofman A, Grobee DE (1997) Diabetes mellitus, impaired glucose tolerance, and hyperinsulinemia in an elderly population. Am J Epidemiol 145: 24–32

    Article  PubMed  CAS  Google Scholar 

  • Strauer BE, Motz W, Vogt M, Schwartzkopff B (1997) Impaired coronary flow reserve in NIDDM: a possible role for diabetic cardiopathy in humans. Diabetes 46 [Suppl 2]: S119–S124

    PubMed  CAS  Google Scholar 

  • Straumann M, Staffelbach O, Sonnenberg GE, Keller U, Berger W (1979) Vor-und Nachteile der Insulintherapie bei älteren Diabetikern mit asymptomatischer Hyperglykämie. Schweiz Med Wochenschr 109: 1816–1820

    PubMed  CAS  Google Scholar 

  • Tater D, Tepaut B, Bercovici JP, Youinou P (1987) Polymorphonuclear cell derangements in type I diabetes. Horm Metab Res 19: 642–647

    Article  PubMed  CAS  Google Scholar 

  • Teuscher A (1986) Die Kohlenhydrate und Nahrungsfasern in der Diabetesdiät. Schweiz Med Wochenschr 116: 282–287

    PubMed  CAS  Google Scholar 

  • The Expert Commitee on the Diagnosis and Classification of Diabetes mellitus (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20: 1183–1197

    Google Scholar 

  • Tobey TA, Greenfield M, Kraemer F, Reaven GM (1981) Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics and plasma triglyceride levels in normotriglyceridemic man. Metabolism 30: 165–171

    Article  PubMed  CAS  Google Scholar 

  • Tragi KH, Schernthaner G, Udvardi G, Kaiser F, Hupka J, Geyer G (1981) Einfluß des Alters auf Glukosetoleranz und Insulinsekretion. Akt Gerontol 11: 114–118

    Google Scholar 

  • Tragi KH (1983) Risikofaktoren und atherosklerotische Komplikationen in Wien: Herzinfarkt und Schlaganfall. Acta Med Austriaca 10: 1–10

    Google Scholar 

  • Uusitupa M, Mustonen J, Laakso M, Vainio P, Länsimies E, Talwar S, Pyörälä K (1988) Impairement of diastolic function in middle-aged type-1 (insulin-dependent) and type-2 (noninsulin-dependent) diabetic patients free of cardiovascular disease. Diabetologia 31: 783–791

    Article  PubMed  CAS  Google Scholar 

  • Van Horn L (1997) Fiber, lipids, and coroary heart disease. Circulation 95: 2701–2704

    Article  PubMed  Google Scholar 

  • Vijan S, Hofer TP, Hyward RA (1997) Estimated benefits of glycemic control in microvascular complications in type 2 diabetes. Ann Intern Med 127: 788–795

    PubMed  CAS  Google Scholar 

  • Vlassara H, Bucala R, Striker L (1994) Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 70: 138–151

    PubMed  CAS  Google Scholar 

  • Waldhäusl W, Freyler H, Bratusch-Marrain P, Vierhapper H, Bruneder H (1983) Kontinuierliche subkutane Insulininfusion. Dtsch Med Wochenschr 108: 570–577

    Article  PubMed  Google Scholar 

  • Waldhäusl W, Czerwenka-Howorka K (1985) Moderne Insulintherapie. Wien Med Wochenschr 135: 151–159

    PubMed  Google Scholar 

  • Walinder O, Wibell L, Boström H (1980) The clinical value of HbAlc-determination. Acta Med Scand [Suppl] 639: 17–22

    CAS  Google Scholar 

  • Winocour PD (1992) Platelet abnormalities in diabetes mellitus. Diabetes 41 [Suppl 2]: 26–31

    PubMed  Google Scholar 

  • Wisotzky J, Sommer M, Schubert K, Stein G (1996) Die Akkumulation von AGE im Alterungsprozeß, bei Diabetes mellitus und bei der chronischen Niereninsuffizienz. Med Klinik 91: 454–457

    CAS  Google Scholar 

  • Yeap BB, Wittert GA, Russo A, Horowitz M, Fraser RJ (1996) Hyperglycemia affects cardiovascular autonomic nerve function in normal subjects. Diabetes Care 19: 880–882

    Article  PubMed  CAS  Google Scholar 

  • Zander E, Heinke P, Gottschling D, Zander G, Strese J, Herfurth S, Michaelis D (1997) Increased prevalence of elevazed urinary albumin excretion rate in type 2 diabetic patients suffering from ischemic foot lesions. Exp Clin Endocrinol Diab 105 [Suppl 2]: 51–53

    Article  CAS  Google Scholar 

  • Zarich SW, Nesto RW (1989) Diabetic cardiomyopathy. Am Heart J 118: 1000–1012

    Article  PubMed  CAS  Google Scholar 

  • Zhuang HX, Wuarin L, Fei ZJ, Ishii DN (1997) Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. J Pharmacol Exp Ther 283: 366–374

    PubMed  CAS  Google Scholar 

  • Ziegler D, Wiefels K, Dannehl K, Gries FA (1988) Effects of one year of near-normoglycemia on peripheral nerve function in type-1 (insulindependent) diabetic patients. Klin Wochenschr 66: 388–396

    Article  PubMed  CAS  Google Scholar 

  • Zimmet PZ, Alberti KGMM (1997) The changing face of macrovascular disease in non-insulindependent diabetes mellitus: an epidemic in progress. Lancet 350 [Suppl 1]: 1–4

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. I. Medizinischen Abteilung, Donauspitals, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

  2. Ludwig-Boltzmann-Institutes für Altersforschung, Donauspital, Langobardenstraße 122, A-1220, Wien, Österreich

    Univ.-Prof. Dr. Karl Heinz Tragl (Vorstand, Ärztlicher Leiter, Leiter)

Authors
  1. Univ.-Prof. Dr. Karl Heinz Tragl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Wien

About this chapter

Cite this chapter

Tragl, K.H. (1999). Glukosetoleranz und Diabetes mellitus im Alter. In: Handbuch der Internistischen Geriatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6409-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6409-9_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7317-6

  • Online ISBN: 978-3-7091-6409-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation